scholarly journals Zwitterionic Modification of Ultrasmall Iron Oxide Nanoparticles for Reduced Protein Corona Formation

ChemPlusChem ◽  
2017 ◽  
Vol 82 (4) ◽  
pp. 638-646 ◽  
Author(s):  
Karina Pombo-García ◽  
Carmen L. Rühl ◽  
Raymond Lam ◽  
José A. Barreto ◽  
Ching-Seng Ang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Corona Formation

scholarly journals Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles

Materials ◽  
2019 ◽  
Vol 12 (14) ◽  
pp. 2218 ◽  
Author(s):  
Amalia Ruiz ◽  
Adán Alpízar ◽  
Lilianne Beola ◽  
Carmen Rubio ◽  
Helena Gavilán ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Raw 264.7 Cells ◽  
Oxide Nanoparticles ◽  
Mri Imaging ◽  
Corona Formation

Superparamagnetic iron oxide nanoparticles are one of the most prominent agents used in theranostic applications, with MRI imaging the main application assessed. The biomolecular interface formed on the surface of a nanoparticle in a biological medium determines its behaviour in vitro and in vivo. In this study, we have compared the formation of the protein corona on highly monodisperse iron oxide nanoparticles with two different coatings, dimercaptosuccinic acid (DMSA), and after conjugation, with a bifunctional polyethylene glycol (PEG)-derived molecule (2000 Da) in the presence of Wistar rat plasma. The protein fingerprints around the nanoparticles were analysed in an extensive proteomic study. The results presented in this work indicate that the composition of the protein corona is very difficult to predict. Proteins from different functional categories—cell components, lipoproteins, complement, coagulation, immunoglobulins, enzymes and transport proteins—were identified in all samples with very small variability. Although both types of nanoparticles have similar amounts of bonded proteins, very slight differences in the composition of the corona might explain the variation observed in the uptake and biotransformation of these nanoparticles in Caco-2 and RAW 264.7 cells. Cytotoxicity was also studied using a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Controlling nanoparticles’ reactivity to the biological environment by deciding on its surface functionalization may suggest new routes in the control of the biodistribution, biodegradation and clearance of multifunctional nanomedicines.

scholarly journals Effect of Surface Chemistry and Associated Protein Corona on the Long-Term Biodegradation of Iron Oxide Nanoparticles In Vivo

2018 ◽  
Vol 10 (5) ◽  
pp. 4548-4560 ◽  
Author(s):  
Grazyna Stepien ◽  
María Moros ◽  
Marta Pérez-Hernández ◽  
Marta Monge ◽  
Lucía Gutiérrez ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Effect Of Surface

scholarly journals The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles

Biomaterials ◽  
2011 ◽  
Vol 32 (35) ◽  
pp. 9353-9363 ◽  
Author(s):  
M. Safi ◽  
J. Courtois ◽  
M. Seigneuret ◽  
H. Conjeaud ◽  
J.-F. Berret
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Cellular Internalization

The Differences of the Impact of a Lipid and Protein Corona on the Colloidal Stability, Toxicity, and Degradation Behavior of Iron Oxide Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Martin Rabel ◽  
Paul Warncke ◽  
Maria Thürmer ◽  
Cordula Gruettner ◽  
Christian Bergemann ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Serum Albumin ◽  
Human Plasma ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Protein Corona ◽  
Oxide Nanoparticles ◽  
Degradation Behavior ◽  
Lipid Molecule ◽  
The Impact

Aim: In this study, the influence of a serum albumin (SA) and human plasma (HP) derived protein- and lipid molecule corona on the toxicity and biodegradability of different iron oxide...

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