scholarly journals Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals

ChemPhysChem ◽  
2019 ◽  
Vol 21 (7) ◽  
pp. 589-593
Author(s):  
Paolo Bollella ◽  
Madhura Bellare ◽  
Vasantha Krishna Kadambar ◽  
Zhong Guo ◽  
Kirill Alexandrov ◽  
...  
Keyword(s):  
Boolean Logic ◽  
Chimeric Enzymes ◽  
Input Signals

scholarly journals Front Cover: Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals (ChemPhysChem 7/2020)

ChemPhysChem ◽  
2020 ◽  
Vol 21 (7) ◽  
pp. 575-575
Author(s):  
Paolo Bollella ◽  
Madhura Bellare ◽  
Vasantha Krishna Kadambar ◽  
Zhong Guo ◽  
Kirill Alexandrov ◽  
...  
Keyword(s):  
Boolean Logic ◽  
Front Cover ◽  
Chimeric Enzymes ◽  
Input Signals

scholarly journals Boolean Logic Networks Mimicked with Chimeric Enzymes Activated/Inhibited by Several Input Signals

ChemPhysChem ◽  
2020 ◽  
Vol 21 (7) ◽  
pp. 578-578
Author(s):  
Paolo Bollella ◽  
Madhura Bellare ◽  
Vasantha Krishna Kadambar ◽  
Zhong Guo ◽  
Kirill Alexandrov ◽  
...  
Keyword(s):  
Boolean Logic ◽  
Chimeric Enzymes ◽  
Input Signals

scholarly journals Modeling signaling-dependent pluripotent cell states with boolean logic can predict cell fate transitions

2017 ◽  
Author(s):  
Ayako Yachie-Kinoshita ◽  
Kento Onishi ◽  
Joel Ostblom ◽  
Eszter Posfai ◽  
Janet Rossant ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Fate ◽  
Expression Patterns ◽  
Embryonic Stem ◽  
Boolean Logic ◽  
Connected Components ◽  
Dynamic Heterogeneity ◽  
Stable States ◽  
Input Signals ◽  
Multiple Stable States

Pluripotent stem cells (PSCs) exist in multiple stable states, each with specific cellular properties and molecular signatures. The process by which pluripotency is either maintained or destabilized to initiate specific developmental programs is poorly understood. We have developed a model to predict stabilized PSC gene regulatory network (GRN) states in response to combinations of input signals. While previous attempts to model PSC fate have been limited to static cell compositions, our approach enables simulations of dynamic heterogeneity by combining an Asynchronous Boolean Simulation (ABS) strategy with simulated single cell fate transitions using Strongly Connected Components (SCCs). This computational framework was applied to a reverse-engineered and curated core GRN for mouse embryonic stem cells (mESCs) to simulate responses to LIF, Wnt/β-catenin, FGF/ERK, BMP4, and Activin A/Nodal pathway activation. For these input signals, our simulations exhibit strong predictive power for gene expression patterns, cell population composition, and nodes controlling cell fate transitions. The model predictions extend into early PSC differentiation, demonstrating, for example, that a Cdx2-high/Oct4-low state can be efficiently and robustly generated from mESCs residing in a naïve and signal-receptive state sustained by combinations of signaling activators and inhibitors.One Sentence SummaryPredictive control of pluripotent stem cell fate transitions

Boolean Logic Gates that Use Enzymes as Input Signals

ChemBioChem ◽  
2008 ◽  
Vol 9 (8) ◽  
pp. 1260-1266 ◽  
Author(s):  
Guinevere Strack ◽  
Marcos Pita ◽  
Maryna Ornatska ◽  
Evgeny Katz
Keyword(s):  
Logic Gates ◽  
Boolean Logic ◽  
Input Signals ◽  
Boolean Logic Gates

scholarly journals Engineering calcium signaling of astrocytes for neural–molecular computing logic gates

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael Taynnan Barros ◽  
Phuong Doan ◽  
Meenakshisundaram Kandhavelu ◽  
Brendan Jennings ◽  
Sasitharan Balasubramaniam
Keyword(s):  
Time Slot ◽  
Logic Gates ◽  
Boolean Logic ◽  
Molecular Computing ◽  
Learning Platform ◽  
Input Signals ◽  
Reinforced Learning ◽  
Wet Lab ◽  
Flow Through ◽  
New Generation

AbstractThis paper proposes the use of astrocytes to realize Boolean logic gates, through manipulation of the threshold of $$\hbox {Ca}^{2+}$$ Ca 2 + ion flows between the cells based on the input signals. Through wet-lab experiments that engineer the astrocytes cells with pcDNA3.1-hGPR17 genes as well as chemical compounds, we show that both AND and OR gates can be implemented by controlling $$\hbox {Ca}^{2+}$$ Ca 2 + signals that flow through the population. A reinforced learning platform is also presented in the paper to optimize the $$\hbox {Ca}^{2+}$$ Ca 2 + activated level and time slot of input signals $$T_b$$ T b into the gate. This design platform caters for any size and connectivity of the cell population, by taking into consideration the delay and noise produced from the signalling between the cells. To validate the effectiveness of the reinforced learning platform, a $$\hbox {Ca}^{2+}$$ Ca 2 + signalling simulator was used to simulate the signalling between the astrocyte cells. The results from the simulation show that an optimum value for both the $$\hbox {Ca}^{2+}$$ Ca 2 + activated level and time slot of input signals $$T_b$$ T b is required to achieve up to 90% accuracy for both the AND and OR gates. Our method can be used as the basis for future Neural–Molecular Computing chips, constructed from engineered astrocyte cells, which can form the basis for a new generation of brain implants.

Switchable electrode controlled by Boolean logic gates using enzymes as input signals

2009 ◽  
Vol 77 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Xuemei Wang ◽  
Jian Zhou ◽  
Tsz Kin Tam ◽  
Evgeny Katz ◽  
Marcos Pita
Keyword(s):  
Logic Gates ◽  
Boolean Logic ◽  
Input Signals ◽  
Boolean Logic Gates

A Delta-Sigma Modulator Using a Non-uniform Quantizer Adjusted for the Probability Density of Input Signals

2012 ◽  
Vol E95.B (7) ◽  
pp. 2257-2265
Author(s):  
Toru KITAYABU ◽  
Mao HAGIWARA ◽  
Hiroyasu ISHIKAWA ◽  
Hiroshi SHIRAI
Keyword(s):  
Probability Density ◽  
Delta Sigma Modulator ◽  
Delta Sigma ◽  
Input Signals

scholarly journals Pediatric Residents and Interns in an Italian Hospital Perform Improved Bibliographic Searches when Assisted by a Biomedical Librarian

2013 ◽  
Vol 8 (1) ◽  
pp. 76
Author(s):  
Mathew Stone
Keyword(s):  
Teaching Hospital ◽  
Assessment Tool ◽  
Controlled Trial ◽  
Intervention Group ◽  
Real Life ◽  
Boolean Logic ◽  
Bibliographic Databases ◽  
Control Group ◽  
Pediatric Residents ◽  
Clinical Scenarios

A Review of: Gardois, P., Calabrese, R., Colombi, N., Lingua, C., Longo, F., Villanacci, M., Miniero, R., & Piga, A. (2011). Effectiveness of bibliographic searches performed by paediatric residents and interns assisted by librarian. A randomised controlled trial. Health Information and Libraries Journal, 28(4), 273-284. doi: 10.1111/j.1471-1842.2011.00957.x Objective – To establish whether the assistance of an experienced biomedical librarian delivers an improvement in the searching of bibliographic databases as performed by medical residents and interns. Design – Randomized controlled trial. Setting – The pediatrics department of a large Italian teaching hospital. Subjects – 18 pediatric residents and interns. Methods – 23 residents and interns from the pediatrics department of a large Italian teaching hospital were invited to participate in this study, of which 18 agreed. Subjects were then randomized into two groups and asked to spend between 30 and 90 minutes searching bibliographic databases for evidence to answer a real-life clinical question which was randomly allocated to them. Each member of the intervention group was provided with an experienced biomedical librarian to provide assistance throughout the search session. The control group received no assistance. The outcome of the search was then measured using an assessment tool adapted for the purpose of this study from the Fresno test of competence in evidence based medicine. This adapted assessment tool rated the “global success” of the search and included criteria such as appropriate question formulation, number of PICO terms translated into search terms, use of Boolean logic, use of subject headings, use of filters, use of limits, and the percentage of citations retrieved that matched a gold standard set of citations found in a prior search by two librarians (who were not involved in assisting the subjects) together with an expert clinician. Main Results – The intervention group scored a median average of 73.6 points out of a possible 100, compared with the control group which scored 50.4. The difference of 23.2 points in favour of the librarian assisted group was a statistically significant result (p value = 0.013) with a 95% confidence interval of between 4.8 and 33.2. Conclusion – This study presents credible evidence that assistance provided by an experienced biomedical librarian improves the quality of the bibliographic database searches performed by residents and interns using real-life clinical scenarios.

scholarly journals Digital logic gates in soft, conductive mechanical metamaterials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Charles El Helou ◽  
Philip R. Buskohl ◽  
Christopher E. Tabor ◽  
Ryan L. Harne
Keyword(s):  
Integrated Circuits ◽  
Electronic Materials ◽  
Polymer Networks ◽  
Conductive Polymer ◽  
Network Connectivity ◽  
Logic Gates ◽  
Boolean Logic ◽  
Digital Logic ◽  
Mechanical Metamaterials ◽  
Logic Operations

AbstractIntegrated circuits utilize networked logic gates to compute Boolean logic operations that are the foundation of modern computation and electronics. With the emergence of flexible electronic materials and devices, an opportunity exists to formulate digital logic from compliant, conductive materials. Here, we introduce a general method of leveraging cellular, mechanical metamaterials composed of conductive polymers to realize all digital logic gates and gate assemblies. We establish a method for applying conductive polymer networks to metamaterial constituents and correlate mechanical buckling modes with network connectivity. With this foundation, each of the conventional logic gates is realized in an equivalent mechanical metamaterial, leading to soft, conductive matter that thinks about applied mechanical stress. These findings may advance the growing fields of soft robotics and smart mechanical matter, and may be leveraged across length scales and physics.

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