A Randomized, Double‐Blind, Single‐Dose, Crossover Study to Demonstrate the Bioequivalence of 2 Formulations of Albiglutide in Healthy Adult Participants

2018 ◽  
Vol 8 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Bonnie C. Shaddinger ◽  
Georgios Vlasakakis ◽  
Joseph Soffer ◽  
Karl M. Thorpe ◽  
Daniel Hatch ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Adult ◽  
Double Blind ◽  
Adult Participants

scholarly journals Bioequivalence evaluation of two capsule formulations of amoxicillin in healthy adult male bangladeshi volunteers: A single-dose, randomized, open-label, two-period crossover study

2008 ◽  
Vol 69 (6) ◽  
pp. 504-513 ◽  
Author(s):  
Ashik Ullah ◽  
Mohammad Abul Kalam Azad ◽  
Rebeka Sultana ◽  
Maruf Mohammad Akbor ◽  
Ahasanul Hasan ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Adult Male ◽  
Healthy Adult ◽  
Open Label ◽  
Healthy Adult Male

scholarly journals Randomised, double-blind, placebo-controlled crossover study of single-dose guanfacine in unilateral neglect following stroke

2018 ◽  
Vol 89 (6) ◽  
pp. 593-598 ◽  
Author(s):  
Edwin S Dalmaijer ◽  
Korina M S Li ◽  
Nikos Gorgoraptis ◽  
Alexander P Leff ◽  
David L Cohen ◽  
...  
Keyword(s):  
Working Memory ◽  
Single Dose ◽  
Crossover Study ◽  
Functional Outcome ◽  
Sustained Attention ◽  
Spatial Working Memory ◽  
Double Blind ◽  
Unilateral Neglect ◽  
Directional Bias ◽  
Double Blind Placebo

ObjectiveUnilateral neglect is a poststroke disorder that impacts negatively on functional outcome and lacks established, effective treatment. This multicomponent syndrome is characterised by a directional bias of attention away from contralesional space, together with impairments in several cognitive domains, including sustained attention and spatial working memory. This study aimed to test the effects of guanfacine, a noradrenergic alpha-2A agonist, on ameliorating aspects of neglect.MethodsThirteen right hemisphere stroke patients with leftward neglect were included in a randomised, double-blind, placebo-controlled proof-of-concept crossover study that examined the effects of a single dose of guanfacine. Patients were tested on a computerised, time-limited cancellation paradigm, as well as tasks that independently assessed sustained attention and spatial working memory.ResultsOn guanfacine, there was a statistically significant improvement in the total number of targets found on the cancellation task when compared with placebo (mean improvement of 5, out of a possible 64). However, there was no evidence of a change in neglect patients’ directional attention bias. Furthermore, Bayesian statistical analysis revealed reliable evidence against any effects of guanfacine on search organisation and performance on our sustained attention and spatial working memory tasks.ConclusionsGuanfacine improves search in neglect by boosting the number of targets found but had no effects on directional bias or search organisation, nor did it improve sustained attention or working memory on independent tasks. Further work is necessary to determine whether longer term treatment with guanfacine may be effective for some neglect patients and whether it affects functional outcome measures.Trial registration numberNCT00955253.

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