A Pharmacokinetic Study of an Ibuprofen Topical Patch in Healthy Male and Female Adult Volunteers

2018 ◽  
Vol 7 (7) ◽  
pp. 684-691 ◽  
Author(s):  
Fraser Lewis ◽  
Mark P. Connolly ◽  
Aomesh Bhatt
Keyword(s):  
Pharmacokinetic Study ◽  
Healthy Male ◽  
Female Adult ◽  
Male And Female ◽  
Adult Volunteers ◽  
Topical Patch

The impact of maternal protein restriction during perinatal life on the response to a septic insult in adult rats

2020 ◽  
pp. 1-8
Author(s):  
Reza Khazaee ◽  
Anastasiya Vinokurtseva ◽  
Lynda A. McCaig ◽  
Cory Yamashita ◽  
Daniel B. Hardy ◽  
...  
Keyword(s):  
Control Diet ◽  
Protein Restriction ◽  
Saline Control ◽  
Female Adult ◽  
Adult Rats ◽  
Male And Female ◽  
Maternal Protein Restriction ◽  
And Control ◽  
The Impact ◽  
Septic Insult

Abstract Although abundant evidence exists that adverse events during pregnancy lead to chronic conditions, there is limited information on the impact of acute insults such as sepsis. This study tested the hypothesis that impaired fetal development leads to altered organ responses to a septic insult in both male and female adult offspring. Fetal growth restricted (FGR) rats were generated using a maternal protein-restricted diet. Male and female FGR and control diet rats were housed until 150–160 d of age when they were exposed either a saline (control) or a fecal slurry intraperitoneal (Sepsis) injection. After 6 h, livers and lungs were analyzed for inflammation and, additionally, the amounts and function of pulmonary surfactant were measured. The results showed increases in the steady-state mRNA levels of inflammatory cytokines in the liver in response to the septic insult in both males and females; these responses were not different between FGR and control diet groups. In the lungs, cytokines were not detectable in any of the experimental groups. A significant decrease in the relative amount of surfactant was observed in male FGR offspring, but this was not observed in control males or in female animals. Overall, it is concluded that FGR induced by maternal protein restriction does not impact liver and lung inflammatory response to sepsis in either male or female adult rats. An altered septic response in male FGR offspring with respect to surfactant may imply a contribution to lung dysfunction.

scholarly journals Aortic depressor nerve morphometry in male and female adult spontaneously hypertensive rats.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Milena Menezes Amorim ◽  
Jaci Airton Castania ◽  
Helio Cesar Salgado ◽  
Valéria Paula Sassoli Fazan
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Female Adult ◽  
Male And Female ◽  
Spontaneously Hypertensive ◽  
Aortic Depressor Nerve ◽  
Nerve Morphometry
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