scholarly journals Current Concepts in Methadone Metabolism and Transport

2017 ◽  
Vol 6 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Evan D. Kharasch
Keyword(s):  
Methadone Metabolism

Alterations in Methadone Metabolism During Late Pregnancy

1999 ◽  
Vol 18 (4) ◽  
pp. 51-61 ◽  
Author(s):  
Margaret A. E. Jarvis ◽  
Susanna Wu-Pong ◽  
Janet S. Kniseley ◽  
Sidney H. Schnoll
Keyword(s):  
Late Pregnancy ◽  
Methadone Metabolism

scholarly journals Understanding Methadone Metabolism

2008 ◽  
Vol 108 (3) ◽  
pp. 351-352 ◽  
Author(s):  
J David Clark
Keyword(s):  
Methadone Metabolism

Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism

2007 ◽  
Vol 321 (1) ◽  
pp. 389-399 ◽  
Author(s):  
Rheem A. Totah ◽  
Kyle E. Allen ◽  
Pamela Sheffels ◽  
Dale Whittington ◽  
Evan D. Kharasch
Keyword(s):  
Metabolic Interactions ◽  
Methadone Metabolism

scholarly journals Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

2009 ◽  
Vol 101 (3) ◽  
pp. 158-168 ◽  
Author(s):  
Evan D. Kharasch ◽  
Alysa Walker ◽  
Dale Whittington ◽  
Christine Hoffer ◽  
Pamela Sheffels Bedynek
Keyword(s):  
Cyp3a Activity ◽  
Cytochrome P4503a ◽  
Methadone Metabolism

scholarly journals Differences in Methadone Metabolism by CYP2B6 Variants

2015 ◽  
Vol 43 (7) ◽  
pp. 994-1001 ◽  
Author(s):  
Sarah Gadel ◽  
Christina Friedel ◽  
Evan D. Kharasch
Keyword(s):  
Methadone Metabolism

Methadone—metabolism, pharmacokinetics and interactions

2004 ◽  
Vol 50 (6) ◽  
pp. 551-559 ◽  
Author(s):  
A FERRARI ◽  
C COCCIA ◽  
A BERTOLINI ◽  
E STERNIERI
Keyword(s):  
Methadone Metabolism

Methadone Metabolism by Early Gestational Age Placentas

2006 ◽  
Vol 23 (5) ◽  
pp. 287-294 ◽  
Author(s):  
Todd Hieronymus ◽  
Tatiana Nanovskaya ◽  
Sujal Deshmukh ◽  
Ricardo Vargas ◽  
Gary Hankins ◽  
...  
Keyword(s):  
Gestational Age ◽  
Methadone Metabolism

scholarly journals ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients

2020 ◽  
Vol 71 (4) ◽  
pp. 353-358
Author(s):  
Davorka Sutlović ◽  
Željko Ključević ◽  
Sendi Kuret
Keyword(s):  
Hepatitis C ◽  
Genetic Polymorphisms ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Gas Chromatography Mass Spectrometry ◽  
Major Influence ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Methadone Metabolism

AbstractThe aim of this study was to determine the influence of ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms on methadone metabolism in patients with hepatitis C virus (HCV) undergoing methadone maintenance treatment (MMT). The study included 35 participants undergoing MMT, who were divided in three groups: HCV-positive (N=12), HCV-negative (N=16), and HCV clinical remission (CR) (N=7). The concentrations of methadone and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) were determined with gas chromatography-mass spectrometry. The patients were genotyped for ABCB1 rs1045642, CYP2B6 rs3745274, CYP3A4 rs2242480, and CYP3A4 rs2740574 polymorphisms. Differences between single nucleotide polymorphism (SNP) genotypes and methadone-to-EDDP ratio were analysed with one-way ANOVA, which showed no significant difference between the genes (p=0.3772 for ABCB1 rs1045642, p=0.6909 for CYP2B6 rs3745274, and p=0.6533 for CYP3A4 rs2242480). None of the four analysed SNP genotypes correlated with methadone-to-EDDP concentration ratio. A major influence on it in hepatitis C-positive patients turned out to be the stage of liver damage.

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