scholarly journals Differences in Methadone Metabolism by CYP2B6 Variants

2015 ◽  
Vol 43 (7) ◽  
pp. 994-1001 ◽  
Author(s):  
Sarah Gadel ◽  
Christina Friedel ◽  
Evan D. Kharasch
Keyword(s):  
Methadone Metabolism

Alterations in Methadone Metabolism During Late Pregnancy

1999 ◽  
Vol 18 (4) ◽  
pp. 51-61 ◽  
Author(s):  
Margaret A. E. Jarvis ◽  
Susanna Wu-Pong ◽  
Janet S. Kniseley ◽  
Sidney H. Schnoll
Keyword(s):  
Late Pregnancy ◽  
Methadone Metabolism

scholarly journals Understanding Methadone Metabolism

2008 ◽  
Vol 108 (3) ◽  
pp. 351-352 ◽  
Author(s):  
J David Clark
Keyword(s):  
Methadone Metabolism

Enantiomeric Metabolic Interactions and Stereoselective Human Methadone Metabolism

2007 ◽  
Vol 321 (1) ◽  
pp. 389-399 ◽  
Author(s):  
Rheem A. Totah ◽  
Kyle E. Allen ◽  
Pamela Sheffels ◽  
Dale Whittington ◽  
Evan D. Kharasch
Keyword(s):  
Metabolic Interactions ◽  
Methadone Metabolism

scholarly journals Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

2009 ◽  
Vol 101 (3) ◽  
pp. 158-168 ◽  
Author(s):  
Evan D. Kharasch ◽  
Alysa Walker ◽  
Dale Whittington ◽  
Christine Hoffer ◽  
Pamela Sheffels Bedynek
Keyword(s):  
Cyp3a Activity ◽  
Cytochrome P4503a ◽  
Methadone Metabolism

Methadone—metabolism, pharmacokinetics and interactions

2004 ◽  
Vol 50 (6) ◽  
pp. 551-559 ◽  
Author(s):  
A FERRARI ◽  
C COCCIA ◽  
A BERTOLINI ◽  
E STERNIERI
Keyword(s):  
Methadone Metabolism

Methadone Metabolism by Early Gestational Age Placentas

2006 ◽  
Vol 23 (5) ◽  
pp. 287-294 ◽  
Author(s):  
Todd Hieronymus ◽  
Tatiana Nanovskaya ◽  
Sujal Deshmukh ◽  
Ricardo Vargas ◽  
Gary Hankins ◽  
...  
Keyword(s):  
Gestational Age ◽  
Methadone Metabolism

scholarly journals ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients

2020 ◽  
Vol 71 (4) ◽  
pp. 353-358
Author(s):  
Davorka Sutlović ◽  
Željko Ključević ◽  
Sendi Kuret
Keyword(s):  
Hepatitis C ◽  
Genetic Polymorphisms ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Gas Chromatography Mass Spectrometry ◽  
Major Influence ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Methadone Metabolism

AbstractThe aim of this study was to determine the influence of ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms on methadone metabolism in patients with hepatitis C virus (HCV) undergoing methadone maintenance treatment (MMT). The study included 35 participants undergoing MMT, who were divided in three groups: HCV-positive (N=12), HCV-negative (N=16), and HCV clinical remission (CR) (N=7). The concentrations of methadone and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) were determined with gas chromatography-mass spectrometry. The patients were genotyped for ABCB1 rs1045642, CYP2B6 rs3745274, CYP3A4 rs2242480, and CYP3A4 rs2740574 polymorphisms. Differences between single nucleotide polymorphism (SNP) genotypes and methadone-to-EDDP ratio were analysed with one-way ANOVA, which showed no significant difference between the genes (p=0.3772 for ABCB1 rs1045642, p=0.6909 for CYP2B6 rs3745274, and p=0.6533 for CYP3A4 rs2242480). None of the four analysed SNP genotypes correlated with methadone-to-EDDP concentration ratio. A major influence on it in hepatitis C-positive patients turned out to be the stage of liver damage.

scholarly journals The Effect of CYP2B6, CYP2D6, and CYP3A4 Alleles on Methadone Binding: A Molecular Docking Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Nik Nur Syazana Bt Nik Mohamed Kamal ◽  
Theam Soon Lim ◽  
Gee Jun Tye ◽  
Rusli Ismail ◽  
Yee Siew Choong
Keyword(s):  
Binding Affinity ◽  
Methadone Maintenance ◽  
Active Form ◽  
Clinical Effects ◽  
Nucleotide Polymorphisms ◽  
Wild Type ◽  
Molecular Docking Study ◽  
Mutant Type ◽  
Metabolism Rate ◽  
Methadone Metabolism

Current methadone maintenance therapy (MMT) is yet to ensure 100% successful treatment as the optimum dosage has yet to be determined. Overdose leads to death while lower dose causes the opioid withdrawal effect. Single-nucleotide polymorphisms (SNP) in cytochrome P450s (CYPs), the methadone metabolizers, have been showen to be the main factor for the interindividual variability of methadone clinical effects. In this study, we investigated the effect of SNPs in three major methadone metabolizers (CYP2B6, CYP2D6, and CYP3A4) on methadone binding affinity. Results showed thatCYP2B6*11,CYP2B6*12,CYP2B6*18, andCYP3A4*12have significantly higher binding affinity toR-methadone compared to wild type.S-methadone has higher binding affinity inCYP3A4*3,CYP3A4*11, andCYP3A4*12compared to wild type.R-methadone was shown to be the active form of methadone; thus individuals with CYP alleles that binds better toR-methadone will have higher methadone metabolism rate. Therefore, a higher dosage of methadone is necessary to obtain the opiate effect compared to a normal individual and vice versa. These results provide an initial prediction on methadone metabolism rate for individuals with mutant type CYP which enables prescription of optimum methadone dosage for individuals with CYP alleles.

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