Effect of lapatinib on oral digoxin absorption in patients

2015 ◽  
Vol 4 (6) ◽  
pp. 449-453 ◽  
Author(s):  
Kevin M. Koch ◽  
Deborah A. Smith ◽  
Jeff Botbyl ◽  
Nikita Arya ◽  
Linda P. Briley ◽  
...  
Keyword(s):  
Digoxin Absorption

Digoxin Absorption From Tablets and Elixir

JAMA ◽  
1974 ◽  
Vol 230 (11) ◽  
pp. 1554 ◽  
Author(s):  
William J. Jusko
Keyword(s):  
Digoxin Absorption

scholarly journals Influence of soft gelatin on digoxin absorption.

1978 ◽  
Vol 5 (5) ◽  
pp. 461-463 ◽  
Author(s):  
J O'Grady ◽  
BF Johnson ◽  
C Bye ◽  
GA Sabey
Keyword(s):  
Digoxin Absorption

Effect of a standard breakfast on digoxin absorption in normal subjects

1978 ◽  
Vol 23 (3) ◽  
pp. 315-319 ◽  
Author(s):  
B. F. Johnson ◽  
J. O'Grady ◽  
G. A. Sabey ◽  
Carole Bye
Keyword(s):  
Normal Subjects ◽  
Digoxin Absorption ◽  
Standard Breakfast

Research/Practice Reports: Perspectives on Digoxin Absorption from Small Bowel Resections

1983 ◽  
Vol 17 (2) ◽  
pp. 121-123 ◽  
Author(s):  
Kenneth P. Kumer ◽  
John T. Nwangwu ◽  
Peter U. Nwangwu
Keyword(s):  
Small Intestine ◽  
Small Bowel ◽  
Dosage Form ◽  
Bowel Resection ◽  
Common Factors ◽  
Therapeutic Index ◽  
Small Bowel Resection ◽  
Research Practice ◽  
Solid Dosage ◽  
Digoxin Absorption

Digoxin is a commonly prescribed medication for a variety of cardiovascular abnormalities. The therapeutic index of digoxin is considered narrow and drug is absorbed predominantly from the duodenum and upper jejunum. When the small intestine is intact, the absorption can vary; therefore, in the case of a small bowel resection or bypass, this erratic absorption may be accentuated. There is some controversy concerning the effect of small bowel resection or bypass on the absorption of digoxin. Some investigators have shown that small bowel resection or bypass decreases the absorption of oral digoxin, whereas others report no change in absorption. When the study methodologies were evaluated, certain common factors that support each view were found. In most studies reporting malabsorption, a solid dosage form of digoxin was used. Studies reporting no change in absorption investigated a solution dosage form.

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