scholarly journals Magnetic nanofibers based bandage for skin cancer treatment: a non‐invasive hyperthermia therapy

2020 ◽  
Vol 3 (6) ◽  
Author(s):  
Kaushik Suneet ◽  
Tamasa De ◽  
Annapoorni Rangarajan ◽  
Shilpee Jain
Keyword(s):  
Skin Cancer ◽  
Cancer Treatment ◽  
Non Invasive ◽  
Hyperthermia Therapy ◽  
Magnetic Nanofibers

scholarly journals Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Skaidre Jankovskaja ◽  
Johan Engblom ◽  
Melinda Rezeli ◽  
György Marko-Varga ◽  
Tautgirdas Ruzgas ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Relative Increase ◽  
Cancer Biomarker ◽  
Cancer Diagnostics ◽  
Sampling Time ◽  
Skin Permeability ◽  
Experimental Conditions ◽  
Non Invasive

AbstractThe tryptophan to kynurenine ratio (Trp/Kyn) has been proposed as a cancer biomarker. Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics. By performing in vitro pig skin permeability studies, we conclude that non-invasive topical sampling of Trp and Kyn is feasible. We explore the influence of different experimental conditions, which are relevant for the clinical in vivo setting, such as pH variations, sampling time, and microbial degradation of Trp and Kyn. The permeabilities of Trp and Kyn are overall similar. However, the permeated Trp/Kyn ratio is generally higher than unity due to endogenous Trp, which should be taken into account to obtain a non-biased Trp/Kyn ratio accurately reflecting systemic concentrations. Additionally, prolonged sampling time is associated with bacterial Trp and Kyn degradation and should be considered in a clinical setting. Finally, the experimental results are supported by the four permeation pathways model, predicting that the hydrophilic Trp and Kyn molecules mainly permeate through lipid defects (i.e., the porous pathway). However, the hydrophobic indole ring of Trp is suggested to result in a small but noticeable relative increase of Trp diffusion via pathways across the SC lipid lamellae, while the shunt pathway is proposed to slightly favor permeation of Kyn relative to Trp.

scholarly journals Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment

2021 ◽  
Vol 60 (1) ◽  
pp. 223-236
Author(s):  
Walaa Maamoun ◽  
Mohamed I. Badawi ◽  
Ayman A Aly ◽  
Y. Khedr
Keyword(s):  
Silver Nanoparticles ◽  
Liver Cancer ◽  
Cancer Treatment ◽  
Electromagnetic Waves ◽  
Microwave Imaging ◽  
Healthy Tissue ◽  
Cancer Tissue ◽  
Hyperthermia Treatment ◽  
Hyperthermia Therapy ◽  
Surrounding Healthy Tissue

Abstract Hyperthermia therapy is a promising therapy for liver cancer treatment that utilizes external electromagnetic waves to heat the tumor zone to preferentially kill or minimize cancer cells. Nevertheless, it’s a challenge to realize localized heating of the cancer tissue without harming the surrounding healthy tissue. This research proposes to utilize nanoparticles as microwave absorbers to enhance microwave imaging and achieve localized hyperthermia therapy. A realistic 3D abdomen model has been segmented using 3D Slicer segmentation software, and then the obtained segmented CAD model exported to Computer Simulation Technology (CST STUDIO) for applying the Finite Element Modeling (FEM). Next investigating both imaging and treatment capability. Finally, the specific absorption rate (SAR) and temperature distribution were computed without nanoparticles and with different types of nanoparticles such as gold (GNPs) and silver nanoparticles at frequency 915 MHz. By comparing the achived results, it was seen that Silver nanoparticles can make a great enhancement in raising the temperature. However, this result was unsatisfactory but, after adding gold nanoparticles the temperature exceed 42°C, at frequency 915 MHz which is achieving the hyperthermia treatment without harming the nearby healthy tissue, GNPs also can achieve a great enhancement in SAR result

scholarly journals Convolutional Neural Networks Model in Premature Detection of Melanoma

2019 ◽  
Vol 8 (12S2) ◽  
pp. 6-11 ◽  
Keyword(s):  
Neural Networks ◽  
Skin Cancer ◽  
Convolutional Neural Networks ◽  
Additional Data ◽  
Data Set ◽  
Non Invasive ◽  
Convolution Filter ◽  
The University ◽  
Improved Accuracy

The objective of this research is provide to the specialists in skin cancer, a premature, rapid and non-invasive diagnosis of melanoma identification, using an image of the lesion, to apply to the treatment of a patient, the method used is the architecture contrast of Convolutional neural networks proposed by Laura Kocobinski of the University of Boston, against our architecture, which reduce the depth of the convolution filter of the last two convolutional layers to obtain maps of more significant characteristics. The performance of the model was reflected in the accuracy during the validation, considering the best result obtained, which is confirmed with the additional data set. The findings found with the application of this base architecture were improved accuracy from 0.79 to 0.83, with 30 epochs, compared to Kocobinski's AlexNet architecture, it was not possible to improve the accuracy of 0.90, however, the complexity of the network played an important role in the results we obtained, which was able to balance and obtain better results without increasing the epochs, the application of our research is very helpful for doctors, since it will allow them to quickly identify if an injury is melanoma or not and consequently treat it efficiently.

scholarly journals 13-gene DNA Methylation Analysis from Oral Brushing: A Promising Non Invasive Tool in the Follow-up of Oral Cancer Patients

2019 ◽  
Vol 8 (12) ◽  
pp. 2107 ◽  
Author(s):  
Davide B. Gissi ◽  
Achille Tarsitano ◽  
Andrea Gabusi ◽  
Roberto Rossi ◽  
Giuseppe Attardo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Oral Cancer ◽  
Cancer Treatment ◽  
Sample Collection ◽  
Methylation Analysis ◽  
Non Invasive ◽  
Locoregional Relapse ◽  
Positive Score ◽  
Dna Methylation Analysis

Background: This study aimed to evaluate the prognostic value of a non-invasive sampling procedure based on 13-gene DNA methylation analysis in the follow-up of patients previously treated for oral squamous cell carcinoma (OSCC). Methods: The study population included 49 consecutive patients treated for OSCC. Oral brushing sample collection was performed at two different times: before any cancer treatment in the tumor mass and during patient follow-up almost 6 months after OSCC treatment, within the regenerative area after OSCC resection. Each sample was considered positive or negative in relation to a predefined cut-off value. Results: Before any cancer treatment, 47/49 specimens exceeded the score and were considered as positive. Six months after OSCC resection, 16/49 specimens also had positive scores in the samples collected from the regenerative area. During the follow-up period, 7/49 patients developed locoregional relapse: 6/7 patients had a positive score in the regenerative area after OSCC resection. The presence of a positive score after oral cancer treatment was the most powerful variable related to the appearance of locoregional relapse. Conclusion: 13-gene DNA methylation analysis by oral brushing may have a clinical application as a prognostic non-invasive tool in the follow-up of patients surgically treated for OSCC.

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