scholarly journals Topical Administration of Anticancer Drugs for Skin Cancer Treatment

10.5772/27785 ◽  
2011 ◽  
Author(s):  
Stephania Fleury ◽  
Renata Fonseca Vianna Lopez
Keyword(s):  
Skin Cancer ◽  
Cancer Treatment ◽  
Anticancer Drugs ◽  
Topical Administration

Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment

2020 ◽  
Vol 23 (10) ◽  
pp. 1064-1079
Author(s):  
Ahmet Alper Öztürk ◽  
İrem Namlı ◽  
Kadri Güleç ◽  
Şennur Görgülü
Keyword(s):  
Lung Cancer ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Cell Line ◽  
Anticancer Drugs ◽  
Release Kinetics ◽  
Prolonged Release ◽  
Lung Cancer Treatment ◽  
Anticancer Properties ◽  
Ft Ir

Aims: To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in lung cancer treatment. To change the antiviral indication of LAM to anticancer. Background: The development of anticancer drugs is a difficult process. One approach to accelerate the availability of drugs is to reclassify drugs approved for other conditions as anticancer. The most common route of administration of anticancer drugs is intravenous injection. Oral administration of anticancer drugs may considerably change current treatment modalities of chemotherapy and improve the life quality of cancer patients. There is also a potentially significant economic advantage. Objective: To characterize the LAM-loaded-NPs and examine the anticancer activity. Methods: LAM-loaded-NPs were prepared using Nano Spray-Dryer. Properties of NPs were elucidated by particle size (PS), polydispersity index (PDI), zeta potential (ZP), SEM, encapsulation efficiency (EE%), dissolution, release kinetics, DSC and FT-IR. Then, the anticancer activity of all NPs was examined. Results: The PS values of the LAM-loaded-NPs were between 373 and 486 nm. All NPs prepared have spherical structure and positive ZP. EE% was in a range of 61-79%. NPs showed prolonged release and the release kinetics fitted to the Weibull model. NPs structures were clarified by DSC and FT-IR analysis. The results showed that the properties of NPs were directly related to the drug:polymer ratio of feed solution. NPs have potential anticancer properties against A549 cell line at low concentrations and non-toxic to CCD 19-Lu cell line. Conclusion: NPs have potential anticancer properties against human lung adenocarcinoma cells and may induce cell death effectively and be a potent modality to treat this type of cancer. These experiments also indicate that our formulations are non-toxic to normal cells. It is clear that this study would bring a new perspective to cancer therapy.

Clinical Factors Influencing the Outcomes of an Acellular Dermal Matrix for Skin Cancer Treatment: A Retrospective Study

2020 ◽  
Vol 33 (7) ◽  
pp. 367-374
Author(s):  
Barbara Ferrari ◽  
Camilla Reggiani ◽  
Mariangela Francomano ◽  
Pierantonio Bellini ◽  
Federica Ferrari ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Skin Cancer ◽  
Cancer Treatment ◽  
Acellular Dermal Matrix ◽  
Clinical Factors ◽  
Dermal Matrix ◽  
Factors Influencing ◽  
Acellular Dermal

Recent advances of nanotechnology for the delivery of anticancer drugs for breast cancer treatment

2019 ◽  
Vol 50 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Phuong Tran ◽  
Sang-Eun Lee ◽  
Dong-Hyun Kim ◽  
Yong-Chul Pyo ◽  
Jeong-Sook Park
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Anticancer Drugs ◽  
Breast Cancer Treatment ◽  
Recent Advances

Letter: Skin Cancer Treatment Fee Comparisons Inaccurate

2012 ◽  
Vol 38 (12) ◽  
pp. 2038-2039 ◽  
Author(s):  
Howard W. Rogers ◽  
Brett M. Coldiron ◽  
Scott M Dinehart ◽  
Ali Hendi ◽  
George Hruza ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Treatment

Repurposing itraconazole to the benefit of skin cancer treatment: A combined azole-DDAB nanoencapsulation strategy

2018 ◽  
Vol 167 ◽  
pp. 337-344 ◽  
Author(s):  
C. Carbone ◽  
C. Martins-Gomes ◽  
V. Pepe ◽  
A.M. Silva ◽  
T. Musumeci ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Treatment
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