scholarly journals A multiscale subvoxel perfusion model to estimate diffusive capillary wall conductivity in multiple sclerosis lesions from perfusion MRI data

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Timo Koch ◽  
Bernd Flemisch ◽  
Rainer Helmig ◽  
Roland Wiest ◽  
Dominik Obrist
Keyword(s):  
Multiple Sclerosis ◽  
Capillary Wall ◽  
Perfusion Mri ◽  
Wall Conductivity ◽  
Perfusion Model

scholarly journals A multi-scale sub-voxel perfusion model to estimate diffusive capillary wall conductivity in multiple sclerosis lesions from perfusion MRI data

2018 ◽  
Author(s):  
Timo Koch ◽  
Bernd Flemisch ◽  
Rainer Helmig ◽  
Roland Wiest ◽  
Dominik Obrist
Keyword(s):  
Multiple Sclerosis ◽  
Transport Model ◽  
Capillary Wall ◽  
Perfusion Mri ◽  
Patient Specific ◽  
Model Parameters ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Wall Conductivity ◽  
Susceptibility Effects

We propose a new mathematical model to infer capillary leakage coefficients from dynamic susceptibility contrast MRI data. To this end, we derive an embedded mixed-dimension flow and transport model for brain tissue perfusion on a sub-voxel scale. This model is used to obtain the contrast agent concentration distribution in a single MRI voxel during a perfusion MRI sequence. We further present a magnetic resonance signal model for the considered sequence including a model for local susceptibility effects. This allows modeling MR signal--time curves that can be compared to clinical MRI data. The proposed model can be used as a forward model in the inverse modeling problem of inferring model parameters such as the diffusive capillary wall conductivity. Acute multiple sclerosis lesions are associated with a breach in the integrity of the blood brain barrier. Applying the model to perfusion MR data of a patient with acute multiple sclerosis lesions, we conclude that diffusive capillary wall conductivity is a good indicator for characterizing activity of lesions, even if other patient-specific model parameters are not well-known.

scholarly journals What Have We Learned from Perfusion MRI in Multiple Sclerosis?

2018 ◽  
Vol 39 (6) ◽  
pp. 994-1000 ◽  
Author(s):  
E. Lapointe ◽  
D.K.B. Li ◽  
A.L. Traboulsee ◽  
A. Rauscher
Keyword(s):  
Multiple Sclerosis ◽  
Perfusion Mri

scholarly journals Study of changes in perfusion in the foci of demyelination in multiple sclerosis by perfusion MRI

2021 ◽  
Vol 12 (1) ◽  
pp. 30-35
Author(s):  
Yu. A. Stankevich ◽  
L. M. Vasilkiv ◽  
O. B. Bogomyakova ◽  
D. S. Korobko ◽  
N. A. Malkova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Demyelinating Disease ◽  
Perfusion Mri ◽  
Qualitative Assessment ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Neurological Patients ◽  
Progressive Neurodegeneration ◽  
Susceptibility Contrast

Introduction. Multiple sclerosis is a chronic immune-mediated disease of the central nervous system with disseminated foci of demyelination and progressive neurodegeneration; it is the most common demyelinating disease and the leading cause of disability of neurological patients of a young age, characterized by a wave-like course with alternating periods of remission and relapse. Currently, there is a discussion about the participation of vascular changes in the formation of neurological disorders and about the possibility of correction of therapeutic approaches in connection with the revealed microcirculatory disorders. Perfusion MRI allows you to evaluate hemodynamics at the capillary level in vivo. Purpose. To evaluate perfusion changes in foci of demyelination in multiple sclerosis using the method of dynamic susceptibility contrast (DSC). Materials and methods. The MR study was carried out on a super-high-angle MR-scanner «Ingenia» («Philips») 3 Tesla. The study included 30 healthy volunteers and 80 patients with demyelinating disease from 18 to 48 years old (average age was 34,6±8,02 years).Quantitative and qualitative assessment of perfusion indices in foci of demyelination was carried out. Results. In the active foci of demyelination, an increase in the speed and volume of cerebral blood flow is noted, the most pronounced changes in patients with clinically isolated syndrome. Inactive foci, marked hypoperfusion is noted. Discussion. Evaluation of cerebral perfusion allows a new look at the role of the vascular component in the formation of focal inflammatory changes in the brain in multiple sclerosis, which can determine a new direction of pathogenetic treatment. Conclusion. Perfusion data complements routine MRI and provides a comprehensive assessment of the neurovascular system.

Microglia-derived macrophages in early multiple sclerosis plaques

1996 ◽  
Vol 22 (3) ◽  
pp. 207-215 ◽  
Author(s):  
H. Li ◽  
M. L. Cuzner ◽  
J. Newcombe
Keyword(s):  
Multiple Sclerosis
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