Organization of cerebellar cortex secondary to deficit of granule cells in weaver mutant mice

1973 ◽  
Vol 152 (2) ◽  
pp. 133-161 ◽  
Author(s):  
Pasko Rakic ◽  
Richard L. Sidman
Keyword(s):  
Cerebellar Cortex ◽  
Granule Cells ◽  
Mutant Mice

scholarly journals Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex

Neuron ◽  
2016 ◽  
Vol 91 (6) ◽  
pp. 1330-1341 ◽  
Author(s):  
Chong Guo ◽  
Laurens Witter ◽  
Stephanie Rudolph ◽  
Hunter L. Elliott ◽  
Katelin A. Ennis ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Cerebellar Cortex ◽  
Granule Cells

Feedforward Inhibition Controls the Spread of Granule Cell–Induced Purkinje Cell Activity in the Cerebellar Cortex

2007 ◽  
Vol 97 (1) ◽  
pp. 248-263 ◽  
Author(s):  
Fidel Santamaria ◽  
Patrick G. Tripp ◽  
James M. Bower
Keyword(s):  
Cerebellar Cortex ◽  
Granule Cells ◽  
Functional Organization ◽  
Cerebellar Granule Cells ◽  
Molecular Layer ◽  
Cell Activity ◽  
Excitatory Input ◽  
Cortical Inhibition ◽  
Before And After

Synapses associated with the parallel fiber (pf) axons of cerebellar granule cells constitute the largest excitatory input onto Purkinje cells (PCs). Although most theories of cerebellar function assume these synapses produce an excitatory sequential “beamlike” activation of PCs, numerous physiological studies have failed to find such beams. Using a computer model of the cerebellar cortex we predicted that the lack of PCs beams is explained by the concomitant pf activation of feedforward molecular layer inhibition. This prediction was tested, in vivo, by recording PCs sharing a common set of pfs before and after pharmacologically blocking inhibitory inputs. As predicted by the model, pf-induced beams of excitatory PC responses were seen only when inhibition was blocked. Blocking inhibition did not have a significant effect in the excitability of the cerebellar cortex. We conclude that pfs work in concert with feedforward cortical inhibition to regulate the excitability of the PC dendrite without directly influencing PC spiking output. This conclusion requires a significant reassessment of classical interpretations of the functional organization of the cerebellar cortex.

Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex I. In mossy fibers and granule cells

1971 ◽  
Vol 13 (1) ◽  
pp. 15-35 ◽  
Author(s):  
J. C. Eccles ◽  
D. S. Faber ◽  
J. T. Murphy ◽  
N. H. Sabah ◽  
Helena Táboříková
Keyword(s):  
Cerebellar Cortex ◽  
Granule Cells ◽  
Mossy Fibers ◽  
Afferent Volleys
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