Nucleolar changes and development of nissl substance in the cerebral cortex of fetal guinea pigs

1951 ◽  
Vol 94 (3) ◽  
pp. 453-473 ◽  
Author(s):  
Arthur La Velle ◽  
William F. Windle
Keyword(s):  
Cerebral Cortex ◽  
Guinea Pigs ◽  
Nissl Substance

Free amino acid concentrations in cerebral cortex of guinea pigs with epileptogenic lesions

1962 ◽  
Vol 5 (6) ◽  
pp. 525-532 ◽  
Author(s):  
Yo Aelony ◽  
John Logothetis ◽  
Bruce Bart ◽  
Frank Morrell ◽  
Magdaline Bovis
Keyword(s):  
Cerebral Cortex ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Guinea Pigs ◽  
Free Amino ◽  
Amino Acid Concentrations

THE UPTAKE AND DISTRIBUTION OF 14C-CLOMIPHENE CITRATE IN DIFFERENT ORGANS OF NEWBORN FEMALE GUINEA PIGS

1971 ◽  
Vol 68 (3) ◽  
pp. 605-613 ◽  
Author(s):  
K.-D. Schulz ◽  
F. Hölzel ◽  
G. Bettendorf
Keyword(s):  
Cerebral Cortex ◽  
Adrenal Gland ◽  
Guinea Pigs ◽  
Microsomal Fraction ◽  
Clomiphene Citrate ◽  
Time Intervals ◽  
Hypothalamic Region ◽  
Single Subcutaneous Injection ◽  
High Affinity ◽  
Labelled Compound

ABSTRACT Newborn female guinea pigs received a single subcutaneous injection of 150 μg 14C-clomiphene/l00 g body weight. At different time intervals after clomiphene administration the radioactivity was measured in the cerebral cortex, hypothalamic region, pituitary, ovary, liver, adrenal gland and uterus. As early as 1 hour after injection 14C-activity was detectable in all the organs examined. Corresponding to the well-known anti-oestrogenic and oestrogen-like activities of clomiphene, the oestrogenresponsive tissues of the hypothalamic region, pituitary and uterus indicated a high affinity for this compound. Compared with the cerebral cortex, these organs showed a 2- to 7-fold incorporation of 14C-radioactivity 3 hours after the injection. In the uterus a rather constant 14Clevel was maintained during a period of 25 hours. A high uptake and retention of the labelled compound were also detectable in the liver and the adrenal gland. The ovary has the capacity to accumulate a large amount of the 14C-labelled substance. But this ability is only demonstrable during the first 6 hours after clomiphene administration; after this the 14C-activity decreases rapidly, like the 14C-level in the blood plasma. The relevance of this result for the direct effect of clomiphene on ovarian stereoidogenesis is discussed. Furthermore the distribution of l4C-clomiphene was studied in the nuclear, mitochondrial and microsomal fraction and in the particle free supernatant of the above mentioned organs.

scholarly journals Effect of hypoxia on heat-shock proteins (HSPs) in the cerebral cortex of the guinea-pigs newborns

1999 ◽  
Vol 45 (6) ◽  
pp. 907-907
Author(s):  
Giuseppe Buonocore ◽  
Sabrina Liberatori ◽  
Luca Bini ◽  
Vitaliano Pallini ◽  
Om P Mishra ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Guinea Pigs ◽  
Shock Proteins

scholarly journals HYPOXIA-INDUCED MODIFICATION OF GUANOSINE IN THE CEREBRAL CORTEX OF FETAL GUINEA PIGS. † 370

1996 ◽  
Vol 39 ◽  
pp. 64-64
Author(s):  
Om P Mishra ◽  
Alan B Zubrow ◽  
Peter J Marro ◽  
Joanna Kubin ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Cerebral Cortex ◽  
Guinea Pigs

scholarly journals Global Cerebral Ischemia Associated with Cardiac Arrest in the Rat: I. Dynamics of Early Neuronal Changes

1992 ◽  
Vol 12 (2) ◽  
pp. 238-249 ◽  
Author(s):  
Kensuke Kawai ◽  
Liliana Nitecka ◽  
Christl A. Ruetzler ◽  
Goro Nagashima ◽  
Ferenc Joó ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Pyramidal Neurons ◽  
Peripheral Zone ◽  
Gabaergic Neurons ◽  
Stratum Radiatum ◽  
Global Cerebral Ischemia ◽  
Cresyl Violet ◽  
Cytoplasmic Vacuoles ◽  
Nucleus Reticularis ◽  
Nissl Substance

Light microscopic neuronal changes were studied in rats subjected to 10 min of global ischemia produced by compression of the major cardiac vessels. Observations of cresyl violet-stained sections revealed early changes involving predominantly GABAergic neurons in various locations. In rats killed 15 min after recirculation, the changes were characterized by the appearance of a clear peripheral zone with condensation of the remaining neuronal cytoplasm. After 1 h, these zones appeared to be compartmentalized into individual pearl-like vacuoles, especially prominent in the nucleus reticularis thalami. After 3 h, the cytoplasmic vacuoles disappeared and the neuronal changes, particularly in the cerebral cortex, striatum, hippocampus, and pars reticulata of the substantia nigra, consisted mainly of hyperchromasia or loss of Nissl substance. After 2 days, the cerebral cortex and thalamus contained occasional neurons with conspicuously large nucleoli. After 7 days, the hippocampus revealed an approximately 50% loss of CA1 pyramidal neurons, associated with intense microglial reactivity in the stratum radiatum, whereas the neuronal destruction was more complete in the nucleus reticularis thalami. Our observations suggest a possibility that early changes in GABAergic neurons may provide a period of neuronal disinhibition and thus contribute to an excitatory ischemic damage in regions connected by GABAergic circuitry.

Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs

1980 ◽  
Vol 65 (2-3) ◽  
pp. 279-284 ◽  
Author(s):  
Fiorella Casamenti ◽  
Clementina Bianchi ◽  
Lorenzo Beani ◽  
Giancarlo Pepeu
Keyword(s):  
Cerebral Cortex ◽  
Guinea Pigs
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