The early development of the sensory and internuncial cells in the spinal cord of the sheep

1944 ◽  
Vol 81 (2) ◽  
pp. 193-225 ◽  
Author(s):  
Donald H. Barron
Keyword(s):  
Spinal Cord ◽  
Early Development

Mouse Cdx-1 expression during gastrulation

Development ◽  
1993 ◽  
Vol 117 (1) ◽  
pp. 191-203 ◽  
Author(s):  
B.I. Meyer ◽  
P. Gruss
Keyword(s):  
Spinal Cord ◽  
Expression Pattern ◽  
Early Development ◽  
Primitive Streak ◽  
Embryonic Axes ◽  
Specific Expression ◽  
Limb Buds ◽  
Process Formation ◽  
Spinal Cord Level ◽  
Anterior Posterior

We describe the expression pattern of the mouse Cdx-1 gene during early development, examined by both RNA and protein analyses. Cdx-1 expression began with the onset of the head process formation (day 7.5) in ectodermal and mesodermal cells of the primitive streak. Expression extended initially to the middle of the prospective hindbrain and subsequently regressed caudad to the spinal cord level by day 9.5. The mesoderm-specific expression was detected in the first somites and could be followed during their differentiation to the myotome of the dorsal somitic edge by day 12. The developing limb buds and the mesonephros exhibited expression up to day 12. No signal could be detected in notochordal cells and cells of the definitive endoderm. Thus, Cdx-1 is expressed during gastrulation when anterior-posterior positional values are established along the embryonic axes. Furthermore, the expression correlates with the formation of segmented tissue in the posterior hindbrain, the spinal cord and structures like the mesonephros.

Microtubule-associated protein 1a is involved in the early development of the rat spinal cord

1998 ◽  
Vol 246 (2) ◽  
pp. 81-84 ◽  
Author(s):  
M. Oudega ◽  
F. Touri ◽  
M.G.M. Deenen ◽  
B.M. Riederer ◽  
E. Marani
Keyword(s):  
Spinal Cord ◽  
Early Development ◽  
Rat Spinal Cord

scholarly journals Early development of glycine- and GABA-mediated synapses in rat spinal cord

1992 ◽  
Vol 12 (10) ◽  
pp. 3935-3945 ◽  
Author(s):  
WL Wu ◽  
L Ziskind-Conhaim ◽  
MA Sweet
Keyword(s):  
Spinal Cord ◽  
Early Development ◽  
Rat Spinal Cord

Segmental pattern of development of the hindbrain and spinal cord of the zebrafish embryo

Development ◽  
1988 ◽  
Vol 103 (1) ◽  
pp. 49-58 ◽  
Author(s):  
E. Hanneman ◽  
B. Trevarrow ◽  
W.K. Metcalfe ◽  
C.B. Kimmel ◽  
M. Westerfield
Keyword(s):  
Spinal Cord ◽  
Monoclonal Antibody ◽  
Early Development ◽  
Zebrafish Embryo ◽  
Single Cells ◽  
Acetylcholinesterase Activity ◽  
Zebrafish Embryos ◽  
Small Clusters ◽  
Spinal Motoneurones

In the ventral hindbrain and spinal cord of zebrafish embryos, the first neurones that can be identified appear as single cells or small clusters of cells, distributed periodically at intervals equal to the length of a somite. In the hindbrain, a series of neuromeres of corresponding length is present, and the earliest neurones are located in the centres of each neuromere. Young neurones within both the hindbrain and spinal cord were identified in live embryos using Nomarski optics, and histochemically by labelling for acetylcholinesterase activity and expression of an antigen recognized by the monoclonal antibody zn-1. Among them are individually identified hindbrain reticulospinal neurones and spinal motoneurones. These observations suggest that early development in these regions of the CNS reflects a common segmental pattern. Subsequently, as more neurones differentiate, the initially similar patterning of the cells in these two regions diverges. A continuous longitudinal column of developing neurones appears in the spinal cord, whereas an alternating series of large and small clusters of neurones is present in the hindbrain.

scholarly journals Development and aging of human spinal cord circuitries

2017 ◽  
Vol 118 (2) ◽  
pp. 1133-1140 ◽  
Author(s):  
Svend Sparre Geertsen ◽  
Maria Willerslev-Olsen ◽  
Jakob Lorentzen ◽  
Jens Bo Nielsen
Keyword(s):  
Spinal Cord ◽  
Nervous System ◽  
Early Development ◽  
The Body ◽  
Physiological Changes ◽  
Human Spinal Cord ◽  
Spinal Motor ◽  
The World ◽  
New Challenges ◽  
Development And Aging

The neural motor circuitries in the spinal cord receive information from our senses and the rest of the nervous system and translate it into purposeful movements, which allow us to interact with the rest of the world. In this review, we discuss how these circuitries are established during early development and the extent to which they are shaped according to the demands of the body that they control and the environment with which the body has to interact. We also discuss how aging processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries. The complex, multifaceted connectivity of the spinal cord motor circuitries allows them to generate vastly different movements and to adapt their activity to meet new challenges imposed by bodily changes or a changing environment. There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.

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