An experimental investigation of the connections between the corpus striatum and substantia nigra in the cat

1944 ◽  
Vol 80 (3) ◽  
pp. 293-321 ◽  
Author(s):  
Harold Rosegay
Keyword(s):  
Experimental Investigation ◽  
Substantia Nigra ◽  
Corpus Striatum

scholarly journals The localization of function in the brain

1874 ◽  
Vol 22 (148-155) ◽  
pp. 228-232 ◽  
Keyword(s):  
Experimental Investigation ◽  
Grey Matter ◽  
Corpus Striatum ◽  
Lunatic Asylum ◽  
Cerebral Hemispheres ◽  
The West ◽  
Exact Localization ◽  
Medical Reports ◽  
The Brain

The chief contents of this paper are the results of an experimental investigation tending to prove that there is a localization of function in special regions of the cerebral hemispheres. In a former paper published by the author in the ‘West Riding Lunatic Asylum Medical Reports,’ vol. iii. 1873, the results were given of experiments on rabbits, cats, and dogs, made specially for the purpose of testing the theory of Hughlings Jackson, that localized and unilateral epilepsies are caused by irritation or “discharging lesions” of the grey matter of the hemispheres in the region of the corpus striatum. Besides confirming Hughlings Jackson’s views, the author’s researches indicated an exact localization in the hemispheres of centres, or regions, for the carrying out of simple and complex muscular movements of a definite character, and described by him as of a purposive, or expressional, nature.

The pattern of innervation of the corpus striatum by the substantia nigra

Neuroscience ◽  
1981 ◽  
Vol 6 (10) ◽  
pp. 2063-2067 ◽  
Author(s):  
A.K. Wright ◽  
G.W. Arbuthnott
Keyword(s):  
Substantia Nigra ◽  
Corpus Striatum

scholarly journals The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

2018 ◽  
Vol 50 (3) ◽  
pp. 936-951 ◽  
Author(s):  
Jun-Hui Yang ◽  
Run-Jiao Zhang ◽  
Jia-Jie Lin ◽  
Ming-Chao Cao ◽  
Qie Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Substantia Nigra ◽  
Microarray Analysis ◽  
Corpus Striatum ◽  
Neuronal Damage ◽  
Interaction Network ◽  
Differentially Expressed ◽  
Circular Rnas ◽  
Related Factor ◽  
Qrt Pcr

Background/Aims: The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway plays a protective role in both acute neuronal damage and chronic neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases in the central nervous system (CNS). This study aimed to identify the key circRNAs involved in Nrf2-neuroprotection against oxidative stress. Methods: The differentially expressed circRNAs (DEcircRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice were identified by microarray analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) was then used to validate the expression of selected DEcircRNAs in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice. Based on our previous microarray analysis of the differentially expressed mRNAs (DEmRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice, the DEcircRNA-miRNA-DEmRNA interaction network was constructed. Functional annotation of DEmRNAs that shared the same binding miRNAs with DEcircRNAs was performed using gene ontology (GO) and pathway analyses. Results: A total of 65 and 150 significant DEcircRNAs were obtained in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, respectively, and seventeen shared DEcircRNAs were found in both these two tissues. The qRT-PCR results were generally consistent with the microarray results. The DEcircRNA-miRNA-DEmRNA interaction network and pathway analysis indicated that mmu_circRNA_34132, mmu_circRNA_017077 and mmu-circRNA-015216 might be involved with Nrf2-mediated neuroprotection against oxidative stress. Mmu_circRNA_015216 and mmu_circRNA_017077 might play roles in the Nrf2-related transcriptional misregulation and Nrf2-mediated processes of rheumatoid arthritis, respectively. In addition to these two processes, mmu_circRNA_34132 may be a potential regulator of Nrf2-mediated protection for diabetes mellitus and Nrf2-mediated defence against ROS in hearts. Conclusion: In conclusion, our study identified the key DEcircRNAs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, which might provide new clues for further exploring the mechanism of Nrf2-mediated neuroprotection against oxidative stress and other Nrf2-mediated processes.

scholarly journals The aberrantly expressed long non-coding RNA in the substantia nigra and corpus striatum of Nrf2-knockout mice

2017 ◽  
Vol 143 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Jian Liu ◽  
Yali Xu ◽  
Yunxiao Kang ◽  
Shanhu Cao ◽  
Geming Shi ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Knockout Mice ◽  
Corpus Striatum ◽  
Non Coding Rna ◽  
Nrf2 Knockout ◽  
Long Non Coding Rna
Sign in / Sign up

Export Citation Format

Share Document