Effects of penfluridol on dopamine-sensitive adenylate cyclase in corpus striatum and substantia nigra of rats

1976 ◽  
Vol 32 (12) ◽  
pp. 1558-1559
Author(s):  
U. Seeber ◽  
K. Kuschinsky
Keyword(s):  
Substantia Nigra ◽  
Adenylate Cyclase ◽  
Corpus Striatum

Dopamine-sensitive adenylate cyclase and cAMP phosphodiesterase in substantia nigra and corpus striatum of rat brain

Life Sciences ◽  
1976 ◽  
Vol 19 (7) ◽  
pp. 1061-1066 ◽  
Author(s):  
L.J. Traficante ◽  
E. Friedman ◽  
M.A. Oleshansky ◽  
S. Gershon
Keyword(s):  
Substantia Nigra ◽  
Adenylate Cyclase ◽  
Rat Brain ◽  
Corpus Striatum ◽  
Camp Phosphodiesterase

The pattern of innervation of the corpus striatum by the substantia nigra

Neuroscience ◽  
1981 ◽  
Vol 6 (10) ◽  
pp. 2063-2067 ◽  
Author(s):  
A.K. Wright ◽  
G.W. Arbuthnott
Keyword(s):  
Substantia Nigra ◽  
Corpus Striatum

scholarly journals The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

2018 ◽  
Vol 50 (3) ◽  
pp. 936-951 ◽  
Author(s):  
Jun-Hui Yang ◽  
Run-Jiao Zhang ◽  
Jia-Jie Lin ◽  
Ming-Chao Cao ◽  
Qie Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Substantia Nigra ◽  
Microarray Analysis ◽  
Corpus Striatum ◽  
Neuronal Damage ◽  
Interaction Network ◽  
Differentially Expressed ◽  
Circular Rnas ◽  
Related Factor ◽  
Qrt Pcr

Background/Aims: The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway plays a protective role in both acute neuronal damage and chronic neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases in the central nervous system (CNS). This study aimed to identify the key circRNAs involved in Nrf2-neuroprotection against oxidative stress. Methods: The differentially expressed circRNAs (DEcircRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice were identified by microarray analysis. Quantitative real-time polymerase chain reaction (qRT-PCR) was then used to validate the expression of selected DEcircRNAs in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice. Based on our previous microarray analysis of the differentially expressed mRNAs (DEmRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice, the DEcircRNA-miRNA-DEmRNA interaction network was constructed. Functional annotation of DEmRNAs that shared the same binding miRNAs with DEcircRNAs was performed using gene ontology (GO) and pathway analyses. Results: A total of 65 and 150 significant DEcircRNAs were obtained in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, respectively, and seventeen shared DEcircRNAs were found in both these two tissues. The qRT-PCR results were generally consistent with the microarray results. The DEcircRNA-miRNA-DEmRNA interaction network and pathway analysis indicated that mmu_circRNA_34132, mmu_circRNA_017077 and mmu-circRNA-015216 might be involved with Nrf2-mediated neuroprotection against oxidative stress. Mmu_circRNA_015216 and mmu_circRNA_017077 might play roles in the Nrf2-related transcriptional misregulation and Nrf2-mediated processes of rheumatoid arthritis, respectively. In addition to these two processes, mmu_circRNA_34132 may be a potential regulator of Nrf2-mediated protection for diabetes mellitus and Nrf2-mediated defence against ROS in hearts. Conclusion: In conclusion, our study identified the key DEcircRNAs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice, which might provide new clues for further exploring the mechanism of Nrf2-mediated neuroprotection against oxidative stress and other Nrf2-mediated processes.

scholarly journals The aberrantly expressed long non-coding RNA in the substantia nigra and corpus striatum of Nrf2-knockout mice

2017 ◽  
Vol 143 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Jian Liu ◽  
Yali Xu ◽  
Yunxiao Kang ◽  
Shanhu Cao ◽  
Geming Shi ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Knockout Mice ◽  
Corpus Striatum ◽  
Non Coding Rna ◽  
Nrf2 Knockout ◽  
Long Non Coding Rna

Dopamine-sensitive adenylate cyclase: location in substantia nigra

Science ◽  
1977 ◽  
Vol 195 (4277) ◽  
pp. 503-505 ◽  
Author(s):  
K Gale ◽  
A Guidotti ◽  
E Costa
Keyword(s):  
Substantia Nigra ◽  
Adenylate Cyclase
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