scholarly journals Postnatal developmental trajectory of dopamine receptor 1 and 2 expression in cortical and striatal brain regions

2018 ◽  
Vol 527 (6) ◽  
pp. 1039-1055 ◽  
Author(s):  
Ellen R. Cullity ◽  
Heather B. Madsen ◽  
Christina J. Perry ◽  
Jee Hyun Kim
Keyword(s):  
Dopamine Receptor ◽  
Brain Regions ◽  
Developmental Trajectory ◽  
Dopamine Receptor 1

scholarly journals Multidimensional brain-age prediction reveals altered brain developmental trajectory in psychiatric disorders

2020 ◽  
Author(s):  
Xin Niu ◽  
Alexei Taylor ◽  
Russell T. Shinohara ◽  
John Kounios ◽  
Fengqing Zhang
Keyword(s):  
Psychiatric Disorders ◽  
Robust Regression ◽  
Developmental Trajectories ◽  
Brain Structures ◽  
Brain Regions ◽  
Developmental Trajectory ◽  
Imaging Features ◽  
Neuroimaging Data ◽  
Brain Age ◽  
Age Prediction

AbstractBrain regions change in different ways and at different rates. This staggered developmental unfolding is determined by genetics and postnatal experience and is implicated in the progression of psychiatric and neurological disorders. Neuroimaging-based brain-age prediction has emerged as an important new approach for studying brain development. However, the unidimensional brain-age estimates provided by previous methods do not capture the divergent developmental trajectories of various brain structures. Here we propose and illustrate an analytic pipeline to compute an index of multidimensional brain-age that provides regional age predictions. First, using a database of 556 subjects that includes psychiatric and neurological patients as well as healthy controls we conducted robust regression to characterize the developmental trajectory of each MRI-based brain-imaging feature. We then utilized cluster analysis to identify subgroups of imaging features with a similar developmental trajectory. For each identified cluster, we obtained a brain-age prediction by applying machine-learning models with imaging features belonging to each cluster. Brain-age predictions from multiple clusters form a multidimensional brain-age index (MBAI). The MBAI is more sensitive to alterations in brain structures and captured distinct regional change patterns. In particular, the MBAI provided a more flexible analysis of brain age across brain regions that revealed changes in specific structures in psychiatric disorders that would otherwise have been combined in a unidimensional brain age prediction. More generally, brain-age prediction using a subset of homogeneous features circumvents the curse of dimensionality in neuroimaging data.

scholarly journals Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice

2015 ◽  
Vol 279 ◽  
pp. 202-210 ◽  
Author(s):  
Fumiaki Yokoi ◽  
Mai T. Dang ◽  
Jun Liu ◽  
Jason R. Gandre ◽  
Kelly Kwon ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Motor Skill ◽  
Skill Transfer ◽  
Dopamine Receptor 1

scholarly journals Nucleus Accumbens Dopamine Receptor 1 Expressing Neurons Are Instrumental in Appetitive Aggression

2019 ◽  
Vol 39 (34) ◽  
pp. 6610-6612 ◽  
Author(s):  
Martyna Panasiuk ◽  
Alexandra Hertz ◽  
Oliver Gale-Grant
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptor ◽  
Dopamine Receptor 1

scholarly journals Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer

Oncogene ◽  
2015 ◽  
Vol 35 (24) ◽  
pp. 3103-3113 ◽  
Author(s):  
D C Borcherding ◽  
W Tong ◽  
E R Hugo ◽  
D F Barnard ◽  
S Fox ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dopamine Receptor ◽  
Therapeutic Targeting ◽  
Dopamine Receptor 1

scholarly journals Attenuated Dopamine Receptor Signaling in Nucleus Accumbens Core in a Rat Model of Chemically-Induced Neuropathy

2019 ◽  
Author(s):  
D.E. Selley ◽  
M.F. Lazenka ◽  
L.J. Sim-Selley ◽  
D. N. Potter ◽  
Elena H. Chartoff ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptor ◽  
Rat Model ◽  
Brain Regions ◽  
Male Rats ◽  
Formalin Injection ◽  
Receptor Signaling ◽  
Nucleus Accumbens Core ◽  
Protein Activation ◽  
Chemically Induced

ABSTRACTNeuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Previous work in a rat model of neuropathic pain demonstrated that bilateral formalin injection into the hind paws produced mechanical hypersensitivity (allodynia) and depressed responding for intracranial self-stimulation (ICSS). To determine whether neuropathy alters dopamine receptor responsiveness in mesolimbic brain regions, we examined dopamine D1-like and D2-like receptor (D1/2R) signaling and expression in male rats 14 days after bilateral intraplantar formalin injections into both rear paws. D2R-mediated G-protein activation and expression of the D2R long, but not short, isoform were reduced in nucleus accumbens (NAc) core, but not in NAc shell, caudate-putamen (CPu) or ventral tegmental area (VTA) of formalin-compared to saline-treated rats. In addition, D1R-stimulated adenylyl cyclase (AC) activity was also reduced in NAc core, but not in NAc shell or prefrontal cortex, of formalin-treated rats, whereas D1R expression was unaffected. Expression of other proteins involved in dopamine neurotransmission, including dopamine uptake transporter (DAT) and tyrosine hydroxylase (TH), were unaffected by formalin treatment. In behavioral tests, the effects of D2R agonists on ICSS were attenuated in formalin-treated rats, whereas the effects of D1R agonists were unchanged. These results indicate that intraplantar formalin as a model of chemically induced neuropathy produces attenuation of highly specific DA receptor signaling processes in NAc core of male rats.

scholarly journals Developmental resilience of synaptome architecture

2021 ◽  
Author(s):  
Laura Tomas-Roca ◽  
Zhen Qiu ◽  
Erik Fransen ◽  
Ragini Gokhale ◽  
Edita Bulovaite ◽  
...  
Keyword(s):  
Neurodevelopmental Disorders ◽  
Neurodevelopmental Disorder ◽  
Brain Regions ◽  
Developmental Trajectory ◽  
Childhood And Adolescence ◽  
Excitatory Synapses ◽  
Developmental Age ◽  
Homeobox Transcription Factor ◽  
Wide Scale ◽  
Intrinsic Capacity

Neurodevelopmental disorders of genetic origin delay the acquisition of normal abilities and cause disabling phenotypes. Spontaneous attenuation and even complete amelioration of symptoms in early childhood and adolescence occur in many disorders, suggesting that brain circuits possess an intrinsic capacity to repair themselves. We examined the molecular composition of almost a trillion excitatory synapses on a brain-wide scale between birth and adulthood in mice carrying a mutation in the homeobox transcription factor Pax6, a neurodevelopmental disorder model. Pax6 haploinsufficiency had no impact on total synapse number at any age. By contrast, the postnatal expansion of synapse diversity and acquisition of normal synaptome architecture were delayed in all brain regions, interfering with network and cognitive functions. Specific excitatory synapse types and subtypes were affected in two key developmental age-windows. These phenotypes were reversed within 2-3 weeks of onset, restoring synaptome architecture to its normal developmental trajectory. Synapse subtypes with high rates of protein turnover mediated these events. These results show synaptome remodelling confers resilience to neurodevelopmental disorders.

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