scholarly journals Adult ciliary neurotrophic factor receptors help maintain facial motor neuron choline acetyltransferase expression in vivo following nerve crush

2016 ◽  
Vol 525 (5) ◽  
pp. 1206-1215 ◽  
Author(s):  
Nancy Lee ◽  
Carolyn E. Rydyznski ◽  
Matthew S. Rasch ◽  
Dennis S. Trinh ◽  
A. John MacLennan
Keyword(s):  
Motor Neuron ◽  
Choline Acetyltransferase ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Nerve Crush ◽  
Facial Motor Neuron

scholarly journals Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP+ Neurotoxicity

2018 ◽  
Vol 19 (11) ◽  
pp. 3543 ◽  
Author(s):  
Jeong Baek ◽  
Jae Jeong ◽  
Kyoung Kim ◽  
So-Yoon Won ◽  
Young Chung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Ciliary Neurotrophic Factor ◽  
Dopamine Neurons ◽  
Transient Receptor Potential Vanilloid

We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat. However, the detailed mechanisms how microglia-derived oxidative stress is regulated by CAP remain to be determined. Here we report that ciliary neurotrophic factor (CNTF) endogenously produced by CAP-activated astrocytes through TRPV1, but not microglia, inhibits microglial activation and microglia-derived oxidative stress, as assessed by OX-6 and OX-42 immunostaining and hydroethidine staining, respectively, resulting in neuroprotection. The significant increase in levels of CNTF receptor alpha (CNTFRα) expression was evident on microglia in the MPP+-lesioned rat SN and the observed beneficial effects of CNTF was abolished by treatment with CNTF receptor neutralizing antibody. It is therefore likely that CNTF can exert its effect via CNTFRα on microglia, which rescues dopamine neurons in the SN of MPP+-lesioned rats and ameliorates amphetamine-induced rotations. Immunohistochemical analysis revealed also a significantly increased expression of CNTFRα on microglia in the SN from human Parkinson’s disease patients compared with age-matched controls, indicating that these findings may have relevance to the disease. These data suggest that CNTF originated from TRPV1 activated astrocytes may be beneficial to treat neurodegenerative disease associated with neuro-inflammation such as Parkinson’s disease.

Muscle and motor neuron ciliary neurotrophic factor receptor α together maintain adult motor neuron axonsin vivo

2016 ◽  
Vol 44 (12) ◽  
pp. 3023-3034 ◽  
Author(s):  
Nancy Lee ◽  
Carolyn R. Serbinski ◽  
Makayla R. Braunlin ◽  
Matthew S. Rasch ◽  
Carolyn E. Rydyznski ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor Receptor

Effects of administration of ciliary neurotrophic factor on normal motor and sensory peripheral nerves in vivo

1993 ◽  
Vol 604 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
Stuart C. Apfel ◽  
Joseph C. Arezzo ◽  
Mary Moran ◽  
John A. Kessler
Keyword(s):  
Neurotrophic Factor ◽  
Peripheral Nerves ◽  
Ciliary Neurotrophic Factor
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