Muscle and motor neuron ciliary neurotrophic factor receptor α together maintain adult motor neuron axonsin vivo

2016 ◽  
Vol 44 (12) ◽  
pp. 3023-3034 ◽  
Author(s):  
Nancy Lee ◽  
Carolyn R. Serbinski ◽  
Makayla R. Braunlin ◽  
Matthew S. Rasch ◽  
Carolyn E. Rydyznski ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor Receptor

Cloning, Mapping, and Retinal Expression of the Canine Ciliary Neurotrophic Factor Receptor α (CNTFRα)

2003 ◽  
Vol 44 (8) ◽  
pp. 3642 ◽  
Author(s):  
William A. Beltran ◽  
Qi Zhang ◽  
James W. Kijas ◽  
Danian Gu ◽  
Hermann Rohrer ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor Receptor

scholarly journals Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese Weightlifters

2020 ◽  
Vol 34 (11) ◽  
pp. 3037-3041
Author(s):  
Hiroki Homma ◽  
Naoyuki Kobatake ◽  
Yusuke Sekimoto ◽  
Mika Saito ◽  
Yukina Mochizuki ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor Receptor

scholarly journals Identification of ciliary neurotrophic factor receptor α as a mediator of neurotoxicity induced by α-synuclein

PROTEOMICS ◽  
2010 ◽  
Vol 10 (11) ◽  
pp. 2138-2150 ◽  
Author(s):  
Jun Liu ◽  
Min Shi ◽  
Zhen Hong ◽  
JianPeng Zhang ◽  
Joshua Bradner ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor Receptor

scholarly journals Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor α Chain

2008 ◽  
Vol 283 (44) ◽  
pp. 30341-30350 ◽  
Author(s):  
François Rousseau ◽  
Sylvie Chevalier ◽  
Catherine Guillet ◽  
Elisa Ravon ◽  
Caroline Diveu ◽  
...  
Keyword(s):  
Binding Site ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Α Chain ◽  
Ciliary Neurotrophic Factor Receptor

scholarly journals The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway

2004 ◽  
Vol 15 (11) ◽  
pp. 4761-4774 ◽  
Author(s):  
Mark A. Ozog ◽  
Suzanne M. Bernier ◽  
Dave C. Bates ◽  
Bishwanath Chatterjee ◽  
Cecilia W. Lo ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Mrna Levels ◽  
Signal Transducer ◽  
Dye Transfer ◽  
Intercellular Coupling ◽  
Cx43 Expression ◽  
Ciliary Neurotrophic Factor Receptor ◽  
Stat Pathway

Cytokines regulate numerous cell processes, including connexin expression and gap junctional coupling. In this study, we examined the effect of ciliary neurotrophic factor (CNTF) on connexin43 (Cx43) expression and intercellular coupling in astrocytes. Murine cortical astrocytes matured in vitro were treated with CNTF (20 ng/ml), soluble ciliary neurotrophic factor receptor α (CNTFRα) (200 ng/ml), or CNTF-CNTFRα. Although CNTF and CNTFRα alone had no effect on Cx43 expression, the heterodimer CNTF-CNTFRα significantly increased both Cx43 mRNA and protein levels. Cx43 immunostaining correlated with increased intercellular coupling as determined by dye transfer analysis. By using the pharmacological inhibitor α-cyano-(3,4-dihydroxy)-N-benzylcinnamide (AG490), the increase in Cx43 was found to be dependent on the Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Immunocytochemical analysis revealed that CNTF-CNTFRα treatment produced nuclear localization of phosphorylated STAT3, whereas CNTF treatment alone did not. Transient transfection of constructs containing various sequences of the Cx43 promoter tagged to a LacZ reporter into ROS 17/2.8 cells confirmed that the promoter region between -838 to -1693 was deemed necessary for CNTF-CNTFRα to induce heightened expression. CNTF-CNTFRα did not alter Cx30 mRNA levels, suggesting selectivity of CNTF-CNTFRα for connexin signaling. Together in the presence of soluble receptor, CNTF activates the JAK/STAT pathway leading to enhanced Cx43 expression and intercellular coupling.

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