Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors

2016 ◽  
Vol 525 (1) ◽  
pp. 166-185 ◽  
Author(s):  
Eriko Kuramoto ◽  
Shixiu Pan ◽  
Takahiro Furuta ◽  
Yasuhiro R. Tanaka ◽  
Haruki Iwai ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Single Neuron ◽  
Thalamic Neurons ◽  
Virus Vectors ◽  
Neuron Tracing

Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors

2017 ◽  
Vol 525 (18) ◽  
pp. 3821-3839 ◽  
Author(s):  
Eriko Kuramoto ◽  
Haruki Iwai ◽  
Atsushi Yamanaka ◽  
Sachi Ohno ◽  
Haruka Seki ◽  
...  
Keyword(s):  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Thalamic Nucleus ◽  
Virus Vectors ◽  
Neuron Tracing

Application of Virus Vectors for Anterograde Tract-Tracing and Single-Neuron Labeling Studies

2021 ◽  
pp. 303-322
Author(s):  
Hiroyuki Hioki ◽  
Hisashi Nakamura ◽  
Takahiro Furuta
Keyword(s):  
Single Neuron ◽  
Tract Tracing ◽  
Virus Vectors

scholarly journals Representation of actions and outcomes in medial prefrontal cortex during delayed conditional decision-making: Population analyses of single neuron activity

2018 ◽  
Vol 2 ◽  
pp. 239821281877386 ◽  
Author(s):  
Miranda J. Francoeur ◽  
Robert G. Mair
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Single Neuron ◽  
Neuron Activity ◽  
Related Activity ◽  
Response Options ◽  
Single Neuron Activity ◽  
Temporal Organisation ◽  
Matching To Position

Background: To respond adaptively in a dynamic environment, it is important for organisms to utilise information about recent events to decide between response options. Methods: To examine the role of medial prefrontal cortex in adaptive decision-making, we recorded single neuron activity in rats performing a dynamic delayed non-matching to position task. Results: We recorded activity from 1335 isolated neurons, 458 (34%) with criterion event-related activity, of which 431 (94%) exhibited 1 of 10 distinct excitatory response types: five at different times relative to delivery (or lack) of reinforcement following sample and choice responses and five correlated with movements or lever press actions that occurred multiple times in each trial. Normalised population averages revealed a precisely timed cascade of population responses representing the temporal organisation behavioural events that constitute delayed non-matching to position trials. Firing field analyses identified a subset of neurons with restricted spatial fields: responding to the conjunction of a behavioural event with a specific location. Anatomical analyses showed considerable overlap in the distribution of different response types in medial prefrontal cortex with a significant trend for dorsal areas to contain more neurons with action-related activity and ventral areas more responses related to action outcomes. Conclusion: These results indicate that medial prefrontal cortex contains discrete populations of neurons that represent the temporal organisation of actions and outcomes during delayed non-matching to position trials. They support the hypothesis that medial prefrontal cortex promotes flexible control of complex behaviours by action–outcome contingencies.

Dissociation of Spatial-, Object-, and Sound-Coding Neurons in the Mediodorsal Nucleus of the Primate Thalamus

2003 ◽  
Vol 89 (2) ◽  
pp. 1067-1077 ◽  
Author(s):  
Ikuo Tanibuchi ◽  
Patricia S. Goldman-Rakic
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Single Neuron ◽  
Neuronal Responses ◽  
Mediodorsal Nucleus ◽  
Sound Coding ◽  
Spatial Tasks ◽  
Dorsolateral Prefrontal ◽  
Information Segregation ◽  
The Brain

The mediodorsal nucleus (MD) is the thalamic gateway to the prefrontal cortex, an area of the brain associated with spatial and object working memory functions. We have recorded single-neuron activities from the MD nucleus in monkeys trained to perform spatial tasks with peripheral visual stimuli and a nonspatial task with foveally presented pictures of objects and faces—tasks identical to those we have previously used to map regional specializations in the dorso- and ventro-lateral prefrontal cortex, respectively. We found that MD neurons exhibited categorical specificity—either responding selectively to locations in the spatial tasks or preferentially to specific representations of faces and objects in the nonspatial task. Spatially tuned neurons were located in parts of the MD connected with the dorsolateral prefrontal cortex while neurons responding to the identity of stimuli mainly occupied more ventral positions in the nucleus that has its connections with the inferior prefrontal convexity. Neuronal responses to auditory stimuli were also examined, and vocalization sensitive neurons were found in more posterior portions of the MD. We conclude that MD neurons are dissociable by their spatial and nonspatial coding properties in line with their cortical connections and that the principle of information segregation in cortico-cortical pathways extends to the “association” nuclei of the thalamus.

Effects of mGlu2/3 Receptor Activation on Neural Network and Single Neuron Function in a Prefrontal Cortex Optogenetic Model of E/I Imbalance

2020 ◽  
Vol 87 (9) ◽  
pp. S280-S281
Author(s):  
Cornelia Dorner-Ciossek ◽  
Oana Dormann ◽  
Wiebke Nissen ◽  
Niklas Schülert ◽  
Moritz von Heimendahl ◽  
...  
Keyword(s):  
Neural Network ◽  
Prefrontal Cortex ◽  
Single Neuron ◽  
Receptor Activation ◽  
Neuron Function
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