Dorsal and Ventral Parts of Thalamic Nucleus Submedius Project to Different Areas of Rat Orbitofrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors

2017 ◽  
Author(s):  
Eriko Kuramoto ◽  
Haruki Iwai ◽  
Atsushi Yamanaka ◽  
Sachi Ohno ◽  
Haruka Seki ◽  
...  
Keyword(s):  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Thalamic Nucleus ◽  
Virus Vectors ◽  
Neuron Tracing

Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors

2017 ◽  
Vol 525 (18) ◽  
pp. 3821-3839 ◽  
Author(s):  
Eriko Kuramoto ◽  
Haruki Iwai ◽  
Atsushi Yamanaka ◽  
Sachi Ohno ◽  
Haruka Seki ◽  
...  
Keyword(s):  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Thalamic Nucleus ◽  
Virus Vectors ◽  
Neuron Tracing

Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors

2016 ◽  
Vol 525 (1) ◽  
pp. 166-185 ◽  
Author(s):  
Eriko Kuramoto ◽  
Shixiu Pan ◽  
Takahiro Furuta ◽  
Yasuhiro R. Tanaka ◽  
Haruki Iwai ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Single Neuron ◽  
Thalamic Neurons ◽  
Virus Vectors ◽  
Neuron Tracing

Application of Virus Vectors for Anterograde Tract-Tracing and Single-Neuron Labeling Studies

2021 ◽  
pp. 303-322
Author(s):  
Hiroyuki Hioki ◽  
Hisashi Nakamura ◽  
Takahiro Furuta
Keyword(s):  
Single Neuron ◽  
Tract Tracing ◽  
Virus Vectors

Information coding in the rodent prefrontal cortex. II. Ensemble activity in orbitofrontal cortex

1995 ◽  
Vol 74 (2) ◽  
pp. 751-762 ◽  
Author(s):  
G. Schoenbaum ◽  
H. Eichenbaum
Keyword(s):  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Activity Space ◽  
Behavioral Performance ◽  
Single Neurons ◽  
Reward Contingency ◽  
Neuron Firing ◽  
Firing Patterns ◽  
Neural Ensembles ◽  
Odor Discrimination Task

1. Neural activity was recorded from the orbitofrontal cortex (OF) of rats performing an eight-odor discrimination task that included predictable associations between particular odor pairs. A modified linear discriminant analysis was employed to characterize the population response in each trial of the task as a point in an N-dimensional activity space with the firing rate of each cell in the population represented on one of the N dimensions. The ability of the ensemble to discriminate among conditions of a variable was reflected in the tendency of population responses to cluster together in this activity space for repetitions of a given condition. We assessed coding of several variables describing the period of odor sampling, focusing on aspects of current, past, and future events reflected in single-neuron firing patterns, in ensembles composed of 22-138 cells active during the period when the rats sampled the discriminative stimulus in each trial. 2. OF ensembles performed well at discriminating variables with relevance to task demands represented in single-neuron firing patterns, specifically the physical attributes and assigned reward contingency of the current odor as well as the expectation of reward in the following trial that could be inferred from the predictable associations between particular pairs of odors. OF ensembles were able to correctly identify the identity and assigned reward contingency of the current odor in up to 52% (chance = 12.5%) and 99% (chance = 50%) of all trials, respectively, such that the observed behavioral performance required a population of 5,364 odor-responsive cells in the case of odor identity and only 40 cells in the case of valence. Expectations regarding upcoming rewards based on both assigned response contingency and associations between particular pairs of odors were correctly classified in up to 67% (chance = 20%) of all trials such that the observed level of behavioral performance required a population of 3,169 cells. 3. Other information represented in the single-neuron firing patterns, such as the identity and reward contingency of the preceding odor and specific odor-odor associations, was poorly encoded by OF ensembles. Thus neural ensembles in OF may represent only some of the information reflected in single-neuron activity. Stable coding of only the most useful and relevant information by the ensemble might emerge from the tuning properties of single neurons under the influence of the task at hand, producing in the well-trained animal the observed pattern of broad and diverse coding by single neurons and selective, task-relevant coding by neural ensembles in OF.

scholarly journals Partially dissociable roles of OFC and ACC in stimulus-guided and action-guided decision making

2014 ◽  
Vol 111 (9) ◽  
pp. 1717-1720 ◽  
Author(s):  
Abbas Khani
Keyword(s):  
Decision Making ◽  
Anterior Cingulate Cortex ◽  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Functional Specialization ◽  
Complex Picture ◽  
Lesion Studies ◽  
The Brain

Recently, the functional specialization of prefrontal areas of the brain, and, specifically, the functional dissociation of the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), during decision making have become a particular focus of research. A number of neuropsychological and lesion studies have shown that the OFC and ACC have dissociable functions in various dimensions of decision making, which are supported by their different anatomical connections. A recent single-neuron study, however, described a more complex picture of the functional dissociation between these two frontal regions during decision making. Here, I discuss the results of that study and consider alternative interpretations in connection with other findings.

scholarly journals Flexible Use of Predictive Cues beyond the Orbitofrontal Cortex: Role of the Submedius Thalamic Nucleus

2015 ◽  
Vol 35 (38) ◽  
pp. 13183-13193 ◽  
Author(s):  
F. Alcaraz ◽  
A. R. Marchand ◽  
E. Vidal ◽  
A. Guillou ◽  
A. Faugere ◽  
...  
Keyword(s):  
Orbitofrontal Cortex ◽  
Thalamic Nucleus
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