scholarly journals Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system

2014 ◽  
Vol 523 (3) ◽  
pp. 479-494 ◽  
Author(s):  
Lynnmaria Nazareth ◽  
Katie E. Lineburg ◽  
Meng Inn Chuah ◽  
Johana Tello Velasquez ◽  
Fatemeh Chehrehasa ◽  
...  
Keyword(s):  
Early Development ◽  
Olfactory System ◽  
Olfactory Ensheathing Cells ◽  
Phagocytic Cells ◽  
Ensheathing Cells

Olfactory Ensheathing Cells Mediate Neuroplastic Mechanisms After Olfactory Training in Mouse Model

2019 ◽  
Vol 34 (2) ◽  
pp. 217-229 ◽  
Author(s):  
Boo-Young Kim ◽  
JuYeon Park ◽  
EuiJin Kim ◽  
ByungGuk Kim
Keyword(s):  
Olfactory System ◽  
Olfactory Receptors ◽  
Olfactory Ensheathing Cells ◽  
Control Group ◽  
Messenger Ribonucleic Acid ◽  
Beneficial Effects ◽  
Olfactory Neuroepithelium ◽  
Ensheathing Cells ◽  
Olfactory Training ◽  
Stimulation Of

Background Several studies have reported beneficial effects of olfactory training (OT) on the olfactory nervous system. However, the mechanisms underlying the regeneration of the olfactory system induced by OT are still under investigation. Objectives To determine the key mechanisms involved in the olfactory system recovery and to assess the neuroplastic effects of OT. Methods Thirty healthy female C57BL/6 mice were randomly allocated to 4 groups: control, n = 6; anosmia (no treatment), n = 8; OT, n = 8; and steroid treatment; n = 8. Except for the control group, mice were administered 3-methylindole. Anosmia was assessed using a food-finding test (FFT). The olfactory neuroepithelium was for histological examinations, gene ontology with pathway analyses, RNA, and protein studies. Results FFT was significantly reduced at 3 weeks in the OT mice versus steroids (78.27 s vs 156.83 s, P < .008) and controls (78.27 s vs 13.14 s, P < .003), although final outcome in the FFT was similar in these groups. Expression of olfactory and neurogenesis marker was higher in the olfactory neuroepithelium of the OT group than in the anosmia group without treatment. The mechanisms underlying olfactory regeneration might be related to early olfactory receptor stimulation, followed by neurotrophic factor stimulation of neuronal plasticity. Conclusion OT can improve olfactory function and accelerate olfactory recovery. The mechanisms underlying olfactory regeneration might be related to an initial stimulation of olfactory receptors followed by neurogenesis. Olfactory ensheathing cells might play an important role in olfactory regeneration following OT, based on the observed changes in messenger ribonucleic acid (mRNA) and protein expression, as well as the findings of the gene analysis.

Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system

Glia ◽  
2006 ◽  
Vol 55 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Chrystelle Ibanez ◽  
Daisuke Ito ◽  
Malgorzata Zawadzka ◽  
Nick D. Jeffery ◽  
Robin J.M. Franklin
Keyword(s):  
Olfactory System ◽  
Olfactory Ensheathing Cells ◽  
Meningeal Cells ◽  
Ensheathing Cells ◽  
Peripheral Olfactory System
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