scholarly journals Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits

2014 ◽  
Vol 523 (1) ◽  
pp. 75-92 ◽  
Author(s):  
Lauren G. Friedman ◽  
Fréderike W. Riemslagh ◽  
Josefa M. Sullivan ◽  
Roxana Mesias ◽  
Frances M. Williams ◽  
...  
Keyword(s):  
Molecular Control ◽  
Synaptic Localization ◽  
Corticostriatal Circuits

Molecular control and genetic improvement of phosphorus use efficiency in rice

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Qiuju He ◽  
Fei Wang ◽  
Yan Wang ◽  
Hong Lu ◽  
Zhili Yang ◽  
...  
Keyword(s):  
Genetic Improvement ◽  
Phosphorus Use Efficiency ◽  
Molecular Control ◽  
Use Efficiency

scholarly journals Expression Analysis of Zinc Transporters in Nervous Tissue Cells Reveals Neuronal and Synaptic Localization of ZIP4

2021 ◽  
Vol 22 (9) ◽  
pp. 4511
Author(s):  
Chiara A. De Benedictis ◽  
Claudia Haffke ◽  
Simone Hagmeyer ◽  
Ann Katrin Sauer ◽  
Andreas M. Grabrucker
Keyword(s):  
Brain Function ◽  
Zinc Homeostasis ◽  
Zinc Transporters ◽  
Excitatory Synapses ◽  
Short Term ◽  
Synaptic Localization ◽  
Zinc Levels ◽  
Rat Astrocyte ◽  
Cellular Zinc ◽  
The Brain

In the last years, research has shown that zinc ions play an essential role in the physiology of brain function. Zinc acts as a potent neuromodulatory agent and signaling ions, regulating healthy brain development and the function of both neurons and glial cells. Therefore, the concentration of zinc within the brain and its cells is tightly controlled. Zinc transporters are key regulators of (extra-) cellular zinc levels, and deregulation of zinc homeostasis and zinc transporters has been associated with neurodegenerative and neuropsychiatric disorders. However, to date, the presence of specific family members and their subcellular localization within brain cells have not been investigated in detail. Here, we analyzed the expression of all zinc transporters (ZnTs) and Irt-like proteins (ZIPs) in the rat brain. We further used primary rat neurons and rat astrocyte cell lines to differentiate between the expression found in neurons or astrocytes or both. We identified ZIP4 expressed in astrocytes but significantly more so in neurons, a finding that has not been reported previously. In neurons, ZIP4 is localized to synapses and found in a complex with major postsynaptic scaffold proteins of excitatory synapses. Synaptic ZIP4 reacts to short-term fluctuations in local zinc levels. We conclude that ZIP4 may have a so-far undescribed functional role at excitatory postsynapses.

Genetic and molecular control of grain yield in maize

2021 ◽  
Vol 41 (3) ◽  
Author(s):  
Hongwei Zhang ◽  
Yantian Lu ◽  
Yuting Ma ◽  
Junjie Fu ◽  
Guoying Wang
Keyword(s):  
Grain Yield ◽  
Molecular Control
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