Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio)

2009 ◽  
Vol 513 (6) ◽  
pp. 685-701 ◽  
Author(s):  
Antonio Castro ◽  
Manuela Becerra ◽  
María Jesús Manso ◽  
Javier Tello ◽  
Nancy M. Sherwood ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Growth Hormone ◽  
Nervous System ◽  
Danio Rerio ◽  
Growth Hormone Releasing Hormone ◽  
Adult Zebrafish ◽  
Releasing Hormone ◽  
The Central Nervous System

scholarly journals Topographical Analysis of Reactive Zinc in the Central Nervous System of Adult Zebrafish (Danio Rerio)

Zebrafish ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 376-388 ◽  
Author(s):  
Marcos M. Braga ◽  
Denis B. Rosemberg ◽  
Diogo L. de Oliveira ◽  
Cássio M. Loss ◽  
Sandro D. Córdova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Danio Rerio ◽  
Adult Zebrafish ◽  
The Central Nervous System ◽  
Topographical Analysis

Localization of dopamine and its relation to the growth hormone producing cells in the central nervous system of the snail Lymnaea stagnalis

1991 ◽  
Vol 85 (1) ◽  
pp. 1-9 ◽  
Author(s):  
T. R. Werkman ◽  
J. van Minnen ◽  
P. Voorn ◽  
H. W. M. Steinbusch ◽  
B. H. C. Westerink ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Growth Hormone ◽  
Nervous System ◽  
Lymnaea Stagnalis ◽  
The Central Nervous System

scholarly journals Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle

2015 ◽  
Vol 114 (2) ◽  
pp. 1008-1021 ◽  
Author(s):  
Christian Schauer ◽  
Tong Tong ◽  
Hugues Petitjean ◽  
Thomas Blum ◽  
Sophie Peron ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Firing Pattern ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Burst Firing ◽  
Hypothalamic Nucleus ◽  
Hpg Axis ◽  
Releasing Hormone ◽  
The Central Nervous System

Gonadotropin-releasing hormone (GnRH) controls mammalian reproduction via the hypothalamic-pituitary-gonadal (hpg) axis, acting on gonadotrope cells in the pituitary gland that express the GnRH receptor (GnRHR). Cells expressing the GnRHR have also been identified in the brain. However, the mechanism by which GnRH acts on these potential target cells remains poorly understood due to the difficulty of visualizing and identifying living GnRHR neurons in the central nervous system. We have developed a mouse strain in which GnRHR neurons express a fluorescent marker, enabling the reliable identification of these cells independent of the hormonal status of the animal. In this study, we analyze the GnRHR neurons of the periventricular hypothalamic nucleus in acute brain slices prepared from adult female mice. Strikingly, we find that the action potential firing pattern of these neurons alternates in synchrony with the estrous cycle, with pronounced burst firing during the preovulatory period. We demonstrate that GnRH stimulation is sufficient to trigger the conversion from tonic to burst firing in GnRHR neurons. Furthermore, we show that this switch in the firing pattern is reversed by a potent GnRHR antagonist. These data suggest that endogenous GnRH acts on GnRHR neurons and triggers burst firing in these cells during late proestrus and estrus. Our data have important clinical implications in that they indicate a novel mode of action for GnRHR agonists and antagonists in neurons of the central nervous system that are not part of the classical hpg axis.

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