Interference with anoikis-induced cell death of dopamine neurons: Implications for augmenting embryonic graft survival in a rat model of Parkinson's disease

2003 ◽  
Vol 464 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Deanna M. Marchionini ◽  
Timothy J. Collier ◽  
Maria Camargo ◽  
Susan McGuire ◽  
Mark Pitzer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Graft Survival ◽  
Rat Model ◽  
Dopamine Neurons

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 ◽  
Vol 1 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Hldeichi Takayama ◽  
Jasodhara Ray ◽  
Heather K. Raymon ◽  
Andrew Baird ◽  
Joanna Hogg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Graft Survival ◽  
Basic Fibroblast Growth Factor ◽  
Rat Model ◽  
Fibroblast Growth ◽  
And Function

scholarly journals Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current Approaches

2000 ◽  
Vol 9 (2) ◽  
pp. 179-195 ◽  
Author(s):  
Patrik Brundin ◽  
Jenny Karlsson ◽  
Mia Emgård ◽  
Gabriele S. Kaminski Schierle ◽  
Oskar Hansson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Free Radicals ◽  
Growth Factor ◽  
Dopamine Neurons ◽  
Successful Outcome ◽  
Donor Tissue ◽  
Recent Advances ◽  
Tissue Implantation

Neural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3–20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that events preceding actual tissue implantation and during the first week thereafter are crucial, and that apoptosis plays a pivotal role. Triggers that may initiate neuronal death in grafts include donor tissue hypoxia and hypoglycemia, mechanical trauma, free radicals, growth factor deprivation, and excessive extracellular concentrations of excitatory amino acids in the host brain. Four distinct phases during grafting that can involve cell death have been identified: retrieval of the embryo; dissection and preparation of the donor tissue; implantation procedure followed by the immediate period after graft injection; and later stages of graft maturation. During these phases, cell death processes involving free radicals and caspase activation (leading to apoptosis) may be triggered, possibly involving an increase in intracellular calcium. We review different approaches that reduce cell death and increase survival of grafted neurons, typically by a factor of 2–4. For example, changes in transplantation procedure such as improved media and implantation technique can be beneficial. Calcium channel antagonists such as nimodipine and flunarizine improve nigral graft survival. Agents that counteract oxidative stress and its consequences, such as superoxide dismutase overexpression, and lazaroids can significantly increase the survival of transplanted dopamine neurons. Also, the inhibition of apoptosis by a caspase inhibitor has marked positive effects. Finally, basic fibroblast growth factor and members of the transforming growth factor-beta superfamily, such as glial cell line-derived neurotrophic factor, significantly improve the outcome of nigral transplants. These recent advances provide hope for improved survival of transplanted neurons in patients with Parkinson's disease, reducing the need for human embryonic donor tissue and increasing the likelihood of a successful outcome.

scholarly journals Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

2014 ◽  
Vol 15 (5) ◽  
pp. 653-665 ◽  
Author(s):  
Shane Grealish ◽  
Elsa Diguet ◽  
Agnete Kirkeby ◽  
Bengt Mattsson ◽  
Andreas Heuer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Dopamine Neurons ◽  
Preclinical Efficacy

Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease

1986 ◽  
Vol 65 (1) ◽  
Author(s):  
P. Brundin ◽  
O.G. Nilsson ◽  
R.E. Strecker ◽  
O. Lindvall ◽  
B. �stedt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Dopamine Neurons ◽  
Behavioural Effects
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