Abnormal cerebellar histogenesis inPEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency

2003 ◽  
Vol 461 (3) ◽  
pp. 394-413 ◽  
Author(s):  
Phyllis L. Faust
Keyword(s):  
Cerebellar Histogenesis

scholarly journals Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Hourinaz Behesti ◽  
Arif Kocabas ◽  
David E Buchholz ◽  
Thomas S Carroll ◽  
Mary E Hatten
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Affinity Purification ◽  
Brain Regions ◽  
Temporal Shift ◽  
Cerebellar Neurons ◽  
Cerebellar Granule ◽  
Human Cerebellum ◽  
Species Specific ◽  
Cerebellar Histogenesis

Brain development is regulated by conserved transcriptional programs across species, but little is known about divergent mechanisms that create species-specific characteristics. Among brain regions, human cerebellar histogenesis differs in complexity compared with non-human primates and rodents, making it important to develop methods to generate human cerebellar neurons that closely resemble those in the developing human cerebellum. We report a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells (hPSC). Upon transplantation into juvenile mice, hPSC-derived cerebellar granule cells migrated along glial fibers and integrated into the cerebellar cortex. By Translational Ribosome Affinity Purification-seq, we identified an unexpected temporal shift in the expression of RBFOX3 (NeuN) and NEUROD1, which are classically associated with differentiated neurons, in the human outer external granule layer. This molecular divergence may enable the protracted development of the human cerebellum compared to mice.

Cerebellar histogenesis in the lurcher (Lc) mutant mouse

1977 ◽  
Vol 173 (1) ◽  
pp. 205-217 ◽  
Author(s):  
Dorothy A. Swisher ◽  
Doris B. Wilson
Keyword(s):  
Mutant Mouse ◽  
Cerebellar Histogenesis
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