Odorant receptor expression as a function of neuronal maturity in the adult rodent olfactory system

2003 ◽  
Vol 459 (3) ◽  
pp. 209-222 ◽  
Author(s):  
Carrie L. Iwema ◽  
James E. Schwob
Keyword(s):  
Olfactory System ◽  
Odorant Receptor ◽  
Receptor Expression

scholarly journals Deletion of voltage-gated channel affects glomerular refinement and odorant receptor expression in the mouse olfactory system

2007 ◽  
Vol 506 (2) ◽  
pp. 161-179 ◽  
Author(s):  
K.C. Biju ◽  
David Ronald Marks ◽  
Thomas Gerald Mast ◽  
Debra Ann Fadool
Keyword(s):  
Olfactory System ◽  
Odorant Receptor ◽  
Receptor Expression ◽  
Voltage Gated ◽  
Gated Channel

scholarly journals Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System

2002 ◽  
Vol 22 (8) ◽  
pp. 3033-3043 ◽  
Author(s):  
Thomas Bozza ◽  
Paul Feinstein ◽  
Chen Zheng ◽  
Peter Mombaerts
Keyword(s):  
Olfactory System ◽  
Odorant Receptor ◽  
Receptor Expression ◽  
Functional Units

scholarly journals Asynchronous Onset of Odorant Receptor Expression in the Developing Zebrafish Olfactory System

Neuron ◽  
1996 ◽  
Vol 16 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Alison L Barth ◽  
Nicholas J Justice ◽  
John Ngai
Keyword(s):  
Olfactory System ◽  
Odorant Receptor ◽  
Receptor Expression

scholarly journals The cell biology of smell

2010 ◽  
Vol 191 (3) ◽  
pp. 443-452 ◽  
Author(s):  
Shannon DeMaria ◽  
John Ngai
Keyword(s):  
Olfactory System ◽  
Cell Biology ◽  
Odorant Receptor ◽  
Large Family ◽  
G Protein Coupled Receptors ◽  
Odorant Receptors ◽  
Chemical Structures ◽  
Wide Range ◽  
G Protein Coupled ◽  
The Brain

The olfactory system detects and discriminates myriad chemical structures across a wide range of concentrations. To meet this task, the system utilizes a large family of G protein–coupled receptors—the odorant receptors—which are the chemical sensors underlying the perception of smell. Interestingly, the odorant receptors are also involved in a number of developmental decisions, including the regulation of their own expression and the patterning of the olfactory sensory neurons' synaptic connections in the brain. This review will focus on the diverse roles of the odorant receptor in the function and development of the olfactory system.

scholarly journals Olfaction in birds: differential embryonic expression of nine putative odorant receptor genes in the avian olfactory system

1996 ◽  
Vol 55 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Serge Nef ◽  
Igor Allaman ◽  
Hubert Fiumelli ◽  
Edouard De Castro ◽  
Patrick Nef
Keyword(s):  
Olfactory System ◽  
Odorant Receptor

The corepressor Atrophin specifies odorant receptor expression in Drosophila

2013 ◽  
Vol 28 (3) ◽  
pp. 1355-1364 ◽  
Author(s):  
Liza Alkhori ◽  
Anita Öst ◽  
Mattias Alenius
Keyword(s):  
Odorant Receptor ◽  
Receptor Expression

scholarly journals Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66173 ◽  
Author(s):  
Sana Khalid Tharadra ◽  
Adriana Medina ◽  
Anandasankar Ray
Keyword(s):  
Expression Pattern ◽  
Odorant Receptor ◽  
Receptor Expression ◽  
Chemosensory Neurons

scholarly journals A Feedback Mechanism Regulates Odorant Receptor Expression in the Malaria Mosquito, Anopheles gambiae

2020 ◽  
Author(s):  
Sarah E. Maguire ◽  
Ali Afify ◽  
Loyal A. Goff ◽  
Christopher J. Potter
Keyword(s):  
Drosophila Melanogaster ◽  
Anopheles Gambiae ◽  
Odorant Receptor ◽  
Ectopic Expression ◽  
Feedback Mechanism ◽  
Receptor Expression ◽  
Rna Seq ◽  
Human Odor ◽  
Mosquito Anopheles Gambiae ◽  
Almost All

ABSTRACTMosquitoes locate and approach humans (‘host-seek’) when specific Olfactory Neurons (ORNs) in the olfactory periphery activate a specific combination of glomeruli in the mosquito Antennal Lobe (AL). We hypothesize that dysregulating proper glomerular activation in the presence of human odor will prevent host-seeking behavior. In experiments aimed at ectopically activating most ORNs in the presence of human odor, we made a surprising finding: ectopic expression of an AgOr (AgOr2) in Anopheles gambiae ORNs dampens the activity of the expressing neuron. This contrasts studies in Drosophila melanogaster, the typical insect model of olfaction, in which ectopic expression of non-native ORs in ORNs confers ectopic neuronal responses without interfering with native olfactory physiology. To gain insight into this dysfunction in mosquitoes, RNA-seq analyses were performed comparing wild-type antennae to those ectopically expressing AgOr2 in ORNs. Remarkably, almost all Or transcripts were significantly downregulated (except for AgOr2), and additional experiments suggest that it is AgOR2 protein rather than mRNA that mediates this downregulation. Our study shows that ORNs of Anopheles mosquitoes (in contrast to Drosophila) employ a currently unexplored regulatory mechanism of OR expression, which may be adaptable as a vector-control strategy.SIGNIFICANCE STATEMENTStudies in Drosophila melanogaster suggest that insect Olfactory Receptor Neurons (ORNs) do not contain mechanisms by which Odorant Receptors (ORs) regulate OR expression. This has proved useful in studies where ectopic expression of an OR in Drosophila ORNs confers responses to the odorants that activate the newly expressed OR. In experiments in Anopheles gambiae mosquitoes, we found that ectopic expression of an OR in most Anopheles ORNs dampened the activity of the expressing neurons. RNA-seq analyses demonstrated that ectopic OR expression in Anopheles ORNs leads to downregulation of endogenous Or transcripts. Additional experiments suggest that this downregulation required ectopic expression of a functional OR protein. These findings reveal that Anopheles mosquitoes, in contrast to Drosophila, contain a feedback mechanism to regulate OR expression. Mosquito ORNs might employ regulatory mechanisms of OR expression previously thought to occur only in non-insect olfactory systems.

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