scholarly journals Childhood cancer survivorship research in minority populations: A position paper from the Childhood Cancer Survivor Study

Cancer ◽  
2016 ◽  
Vol 122 (15) ◽  
pp. 2426-2439 ◽  
Author(s):  
Smita Bhatia ◽  
Todd M. Gibson ◽  
Kirsten K. Ness ◽  
Qi Liu ◽  
Kevin C. Oeffinger ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cancer Survivorship ◽  
Cancer Survivor ◽  
Position Paper ◽  
Childhood Cancer Survivor ◽  
Minority Populations ◽  
Childhood Cancer Survivorship ◽  
Childhood Cancer Survivor Study

scholarly journals Pediatric Cancer Survivorship Research: Experience of the Childhood Cancer Survivor Study

2009 ◽  
Vol 27 (14) ◽  
pp. 2319-2327 ◽  
Author(s):  
Wendy M. Leisenring ◽  
Ann C. Mertens ◽  
Gregory T. Armstrong ◽  
Marilyn A. Stovall ◽  
Joseph P. Neglia ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cancer Survivorship ◽  
Cancer Survivor ◽  
Pediatric Cancer ◽  
Childhood Cancer Survivor ◽  
Research Experience ◽  
Competing Risks Analysis ◽  
Large Cohort Study ◽  
Childhood Cancer Survivor Study ◽  
High Standards

The Childhood Cancer Survivor Study (CCSS) is a comprehensive multicenter study designed to quantify and better understand the effects of pediatric cancer and its treatment on later health, including behavioral and sociodemographic outcomes. The CCSS investigators have published more than 100 articles in the scientific literature related to the study. As with any large cohort study, high standards for methodologic approaches are imperative for valid and generalizable results. In this article we describe methodological issues of study design, exposure assessment, outcome validation, and statistical analysis. Methods for handling missing data, intrafamily correlation, and competing risks analysis are addressed; each with particular relevance to pediatric cancer survivorship research. Our goal in this article is to provide a resource and reference for other researchers working in the area of long-term cancer survivorship.

scholarly journals Longitudinal Changes in Obesity and Body Mass Index Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study

2008 ◽  
Vol 26 (28) ◽  
pp. 4639-4645 ◽  
Author(s):  
Edward G. Garmey ◽  
Qi Liu ◽  
Charles A. Sklar ◽  
Lillian R. Meacham ◽  
Ann C. Mertens ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Acute Lymphoblastic Leukemia ◽  
Childhood Cancer ◽  
Body Mass ◽  
Cancer Survivor ◽  
Comparison Group ◽  
Lymphoblastic Leukemia ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study

Purpose We examined the rate of increase in the body mass index (BMI; kg/m2) after final height attainment in survivors of acute lymphoblastic leukemia (ALL) and a noncancer comparison group. Methods Childhood Cancer Survivor Study (CCSS) is a retrospectively ascertained cohort study that prospectively tracks the health status of adults who were diagnosed with childhood cancer between 1970 and 1986 and a comparison group of siblings. Changes in BMI from baseline enrollment to time of completion of follow-up (mean interval, 7.8 years) were calculated for 1,451 ALL survivors (mean age, 32.3 years at follow-up) and 2,167 siblings of childhood cancer survivors (mean age, 35.9 years). Results The mean BMI of the CCSS sibling comparison group increased with age (women, 0.25 units/yr, 95% CI, 0.22 to 0.28 units; men, 0.23 units/yr, 95% CI, 0.20 to 0.25 units). Compared with CCSS siblings, ALL survivors who were treated with cranial radiation therapy (CRT) had a significantly greater increase in BMI (women, 0.41 units/yr, 95% CI, 0.37 to 0.45 units; men, 0.29 units/yr; 95% CI, 0.26 to 0.32 units). The rate of BMI increase was not significantly increased for ALL survivors who were treated with chemotherapy alone. Younger age at CRT exposure significantly modified risk. Conclusion CRT used in the treatment of childhood ALL is associated with a greater rate of increasing BMI, particularly among women treated with CRT during the first decade of life. Health care professionals should be aware of this risk and interventions to reduce or manage weight gain are essential in this high-risk population.

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