Clinical and genetic risk factors for radiation‐associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort

Cancer ◽  
2021 ◽  
Author(s):  
Matthew R. Trendowski ◽  
Jessica L. Baedke ◽  
Yadav Sapkota ◽  
Lois B. Travis ◽  
Xindi Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study

scholarly journals Fertility of Male Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2010 ◽  
Vol 28 (2) ◽  
pp. 332-339 ◽  
Author(s):  
Daniel M. Green ◽  
Toana Kawashima ◽  
Marilyn Stovall ◽  
Wendy Leisenring ◽  
Charles A. Sklar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radiation Therapy ◽  
Radiation Dose ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Proportional Hazards ◽  
Chemotherapeutic Agents ◽  
Cox Proportional Hazards ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study

Purpose This study was undertaken to determine the effect of treatment for childhood cancer on male fertility. Patients and Methods We reviewed the fertility of male Childhood Cancer Survivor Study survivor and sibling cohorts who completed a questionnaire. We abstracted the chemotherapeutic agents administered, the cumulative dose of drug administered for selected drugs, and the doses and volumes of all radiation therapy from medical records. Risk factors for siring a pregnancy were evaluated using Cox proportional hazards models. Results The 6,224 survivors age 15 to 44 years who were not surgically sterile were less likely to sire a pregnancy than siblings (hazard ratio [HR], 0.56; 95% CI, −0.49 to 0.63). Among survivors, the HR of siring a pregnancy was decreased by radiation therapy of more than 7.5 Gy to the testes (HR, 0.12; 95% CI, −0.02 to 0.64), higher cumulative alkylating agent dose (AAD) score or treatment with cyclophosphamide (third tertile HR, 0.42; 95% CI, −0.31 to 0.57) or procarbazine (second tertile HR, 0.48; 95% CI, −0.26 to 0.87; third tertile HR, 0.17; 95% CI, −0.07 to 0.41). Compared with siblings, the HR for ever siring a pregnancy for survivors who had an AAD score = 0, a hypothalamic/pituitary radiation dose = 0 Gy, and a testes radiation dose = 0 Gy was 0.91 (95% CI, 0.73 to 1.14; P = .41). Conclusion This large study identified risk factors for decreased fertility that may be used for counseling male cancer patients.

scholarly journals Acute Ovarian Failure in the Childhood Cancer Survivor Study

2006 ◽  
Vol 91 (5) ◽  
pp. 1723-1728 ◽  
Author(s):  
Wassim Chemaitilly ◽  
Ann C. Mertens ◽  
Pauline Mitby ◽  
John Whitton ◽  
Marilyn Stovall ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Ovarian Failure ◽  
Childhood Cancer Survivor ◽  
Patient Treatment ◽  
Small Subset ◽  
Bilateral Oophorectomy ◽  
Ovarian Irradiation ◽  
Childhood Cancer Survivor Study

Context: Defined as the loss of ovarian function within 5 yr of diagnosis, acute ovarian failure (AOF) is known to develop in a subset of survivors of pediatric and adolescent cancers. Its precise incidence is unknown, and data concerning its risk factors are limited. Objective: Our objective was to determine the incidence of and patient/treatment factors associated with AOF in a large cohort of pediatric cancer survivors. Design and Setting: We conducted a retrospective cohort, multicenter study. Patients: Female participants from the Childhood Cancer Survivor Study who were greater than 18 yr of age were considered for inclusion. We excluded survivors who received cranial irradiation at doses of more than 3000 cGy, those with hypothalamic/pituitary tumors, and survivors who underwent bilateral oophorectomy. Survivors who reported never menstruating or who had ceased having menses within 5 yr after their cancer diagnosis were considered to have AOF. Main Outcome: We assessed incidence and risk factors for AOF. Results: Of a total of 3390 eligible survivors, 215 cases (6.3%) developed AOF. Survivors with AOF were older at diagnosis and more likely to have been diagnosed with Hodgkin’s lymphoma or to have received abdominal or pelvic radiotherapy than survivors without AOF. Among survivors with AOF, 116 (54%) had received at least 1000-cGy ovarian irradiation. In a multivariable logistic regression model, increasing doses of ovarian irradiation, exposure to procarbazine, and exposure to cyclophosphamide at ages 13–20 yr were independent risk factors for AOF. Conclusions: AOF develops in a small subset of survivors, especially those treated with at least 1000-cGy ovarian radiation. These results will facilitate patient counseling and selection of candidates for newer fertility preservation techniques.

scholarly journals Risk Factors for Obesity in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2012 ◽  
Vol 30 (3) ◽  
pp. 246-255 ◽  
Author(s):  
Daniel M. Green ◽  
Cheryl L. Cox ◽  
Liang Zhu ◽  
Kevin R. Krull ◽  
Deo Kumar Srivastava ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Root Mean Square ◽  
Cancer Survivor ◽  
Childhood Cancer Survivor ◽  
Equation Modeling ◽  
Mean Square ◽  
Intrapersonal Factors ◽  
Increased Risk ◽  
Childhood Cancer Survivor Study

Purpose Many Childhood Cancer Survivor Study (CCSS) participants are at increased risk for obesity. The etiology of their obesity is likely multifactorial but not well understood. Patients and Methods We evaluated the potential contribution of demographic, lifestyle, treatment, and intrapersonal factors and self-reported pharmaceutical use to obesity (body mass index ≥ 30 kg/m2) among 9,284 adult (> 18 years of age) CCSS participants. Independent predictors were identified using multivariable regression models. Interrelationships were determined using structural equation modeling (SEM). Results Independent risk factors for obesity included cancer diagnosed at 5 to 9 years of age (relative risk [RR], 1.12; 95% CI, 1.01 to 1.24; P = .03), abnormal Short Form–36 physical function (RR, 1.19; 95% CI, 1.06 to 1.33; P < .001), hypothalamic/pituitary radiation doses of 20 to 30 Gy (RR, 1.17; 95% CI, 1.05 to 1.30; P = .01), and paroxetine use (RR, 1.29; 95% CI, 1.08 to 1.54; P = .01). Meeting US Centers for Disease Control and Prevention guidelines for vigorous physical activity (RR, 0.90; 95% CI, 0.82 to 0.97; P = .01) and a medium amount of anxiety (RR, 0.86; 95% CI, 0.75 to 0.99; P = .04) reduced the risk of obesity. Results of SEM (N = 8,244; comparative fit index = 0.999; Tucker Lewis index = 0.999; root mean square error of approximation = 0.014; weighted root mean square residual = 0.749) described the hierarchical impact of the direct predictors, moderators, and mediators of obesity. Conclusion Treatment, lifestyle, and intrapersonal factors, as well as the use of specific antidepressants, may contribute to obesity among survivors. A multifaceted intervention, including alternative drug and other therapies for depression and anxiety, may be required to reduce risk.

scholarly journals Risk factors for smoking among adolescent survivors of childhood cancer: A report from the childhood cancer survivor study

2011 ◽  
Vol 58 (3) ◽  
pp. 428-434 ◽  
Author(s):  
Lisa S. Kahalley ◽  
Leslie A. Robinson ◽  
Vida L. Tyc ◽  
Melissa M. Hudson ◽  
Wendy Leisenring ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer

scholarly journals Physical Performance Limitations in the Childhood Cancer Survivor Study Cohort

2009 ◽  
Vol 27 (14) ◽  
pp. 2382-2389 ◽  
Author(s):  
Kirsten K. Ness ◽  
Melissa M. Hudson ◽  
Jill P. Ginsberg ◽  
Rajaram Nagarajan ◽  
Sue C. Kaste ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Physical Performance ◽  
Cancer Survivor ◽  
Physical Disability ◽  
Childhood Cancer Survivors ◽  
Childhood Cancer Survivor ◽  
Childhood Cancer Survivor Study ◽  
Performance Limitations

Physical performance limitations are one of the potential long-term consequences following diagnosis and treatment for childhood cancer. The purpose of this review is to describe the risk factors for and the participation restrictions that result from physical performance limitations among childhood cancer survivors who participated in the Childhood Cancer Survivor Study (CCSS). Articles previously published from the CCSS cohort related to physical performance limitations were reviewed and the results summarized. Our review showed that physical performance limitations are prevalent among childhood cancer survivors and may increase as they age. Host-based risk factors for physical disability include an original diagnosis of bone tumor, brain tumor, or Hodgkin's disease; female sex; and an income less than $20,000 per year. Treatment-based risk factors include radiation and treatment with a combination of alkylating agents and anthracyclines. Musculoskeletal, neurologic, cardiac, pulmonary, sensory, and endocrine organ system dysfunction also increase the risk of developing a physical performance limitation. In summary, monitoring of physical performance limitations in an aging cohort of childhood cancer survivors is important and will help determine the impact of physical performance limitations on morbidity, mortality, and caregiver burden. In addition, in developing restorative and preventive interventions for childhood cancer survivors, we must take into account the special needs of survivors with physical disability to optimize their health and enhance participation in daily living activities.

Long-term complications of neuroblastoma: A report from the Childhood Cancer Survivor Study

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 9544-9544
Author(s):  
C. Laverdiere ◽  
Q. Liu ◽  
Y. Yasui ◽  
P. C. Nathan ◽  
J. Gurney ◽  
...  
Keyword(s):  
Risk Factors ◽  
Childhood Cancer ◽  
Cancer Survivor ◽  
Significant Risk ◽  
Soft Tissue Sarcomas ◽  
Malignant Neoplasm ◽  
Childhood Cancer Survivor ◽  
Chronic Health ◽  
Childhood Cancer Survivor Study

9544 Background: Neuroblastoma (NB) survivors can develop many complications from their treatment. We evaluated long-term morbidity and mortality in a large cohort of NB survivors. Procedures: Late effects data from 5-year NB survivors diagnosed between 1970–1986 enrolled in the Childhood Cancer Survivor Study (CCSS) were collected from self-administered questionnaires. 832 survivors and 3,899 siblings were included. Treatment data were abstracted from the medical records of all survivors. Late mortality, second malignant neoplasm (SMN), and chronic health conditions were analyzed in relation to treatment factors. Results: 42 survivors (6%) died more than 5 years after their diagnosis (standardized mortality ratio [SMR]:4.8; 95% CI 3.5–6.5). Causes of death included: disease recurrence (n=23), SMN (n=6) (SMR: 8.5; 95% CI 3.1–18.4), cardiac (n=1) (SMR 2.9; 95% CI 0.04–16.0), pulmonary (n=1) (SMR 4.8; 95% CI 0.1–26.5), external causes (n=4), other and unknown (n=11). 33 developed a SMN (standardized incidence ratio [SIR] 8.6; 95% CI 5.9–12.1): thyroid (n=7), renal (n=6), soft tissue sarcomas (n=3), acute myeloid leukemia (n=2), breast cancer (n=2) and other (n=13). Exposure to radiation therapy (RT) (p=0.003) and to VP-16 (p=0.04) were significant risk factors for SMN. 38% of the survivors reported at least one chronic health condition. Compared to siblings, they were more likely to report any chronic condition (risk ratio [RR] 14.7; 95% CI, 12.4–17.6). The most common prevalent conditions included: musculoskeletal (RR 49.8; 95% CI, 27.9–88.8), endocrine (RR 36.2; 95%CI 24.1–54.5), sensory (RR 21.5; 95%CI, 14.6–31.7) and neurological (RR 13.1; 95% CI 10.8–16). A multivariable Poisson regression analysis revealed the following associations: laminectomy (RR 8.6; 95% CI 3.5- 21) and chest RT (RR 2.8; 95% CI 1.3–6.5) as risk factors for scoliosis; age < 1 year at diagnosis (RR 1.9; 95% CI 1.4–2.6) and laminectomy (RR 3.5; 95% CI 2.4–5.3) for neurological complications; for hearing loss, increasing cumulative dose of cisplatin (for ≥ 600 mg/m2 RR 52.8; 95% CI 10.2–272.5); and RT to the neck (RR 6.6; 95% CI 2.4–18) for hypothyroidism. Conclusions: NB survivors are at risk of developing chronic conditions. Long-term surveillance is required for early detection of these complications. No significant financial relationships to disclose.

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