scholarly journals Early detection of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA analysis in a surveillance program

Cancer ◽  
2013 ◽  
Vol 119 (10) ◽  
pp. 1838-1844 ◽  
Author(s):  
K. C. Allen Chan ◽  
Emily C. W. Hung ◽  
John K. S. Woo ◽  
Paul K. S. Chan ◽  
Sing-Fai Leung ◽  
...  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Keiji Tabuchi ◽  
Masahiro Nakayama ◽  
Bungo Nishimura ◽  
Kentaro Hayashi ◽  
Akira Hara

Nasopharyngeal carcinoma (NPC) is a unique disease with a clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head and neck. NPC is an Epstein-Barr virus-associated malignancy with a marked racial and geographic distribution. Specifically, it is highly prevalent in southern China, Southeast Asia, and the Middle East. To date, most NPC patients have been diagnosed in the advanced stage, but the treatment results for advanced NPC are not satisfactory. This paper provides a brief overview regarding NPC, with the focus on the early detection of initial and recurrent NPC lesions.


2012 ◽  
Vol 23 ◽  
pp. ix88
Author(s):  
S.H. Hutajulu ◽  
S.R. Indrasari ◽  
L.P.L. Indrawati ◽  
A. Brahmadhi ◽  
S. Duin ◽  
...  

1985 ◽  
Vol 17 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Jen-Yang Chen ◽  
Mei-Ying Liu ◽  
Chien-Jen Chen ◽  
Mow-Ming Hsu ◽  
Shih-Mien Tu ◽  
...  

2020 ◽  
Vol 2 (1) ◽  
pp. 61-68
Author(s):  
Ria Wahyu Januarti

Nasopharyngeal carcinoma is a type of cancer that has a considerable prevalence in Indonesia. Nasopharyngeal cancer is associated with Epstein-Barr virus infection, which also correlates with other factors. These factors are age, genetic, environmental and oral hygiene. Usually, nasopharyngeal cancer is late for diagnosis, so it is always found at an advanced stage. In individuals in risky communities, early detection of nasopharyngeal cancer can be done, without being invasive. The examination that can be done is EBV virus serology analysis and EBV DNA examination. The examination can use simple samples such as nasopharyngeal smear and saliva. This convenience allows early detection of nasopharyngeal cancer so that it can reduce morbidity and mortality.


Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.


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