Real-time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Cancer ◽  
2011 ◽  
Vol 118 (11) ◽  
pp. 2813-2819 ◽  
Author(s):  
Naoyuki Yokoyama ◽  
Tetsuya Otani ◽  
Hideki Hashidate ◽  
Chiyo Maeda ◽  
Tomohiro Katada ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Real Time Detection ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

Real-time intraoperative fluorescence imaging system using light-absorption correction

2009 ◽  
Vol 14 (6) ◽  
pp. 064012 ◽  
Author(s):  
George Themelis ◽  
Jung Sun Yoo ◽  
Kwang-Sup Soh ◽  
Ralf Schulz ◽  
Vasilis Ntziachristos
Keyword(s):  
Real Time ◽  
Fluorescence Imaging ◽  
Light Absorption ◽  
Imaging System ◽  
Absorption Correction ◽  
Fluorescence Imaging System ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

Multimodal fluorescence-guided surgery of colorectal peritoneal metastases, a phase I/II clinical trial.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. TPS4119-TPS4119
Author(s):  
Jan-Marie de Gooyer ◽  
Fortuné Elekonawo ◽  
Andre J.A. Bremers ◽  
Otto Boerman ◽  
Mark Rijpkema ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase I ◽  
Peritoneal Carcinomatosis ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Cytoreductive Surgery ◽  
Peritoneal Metastases ◽  
Colorectal Origin ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

TPS4119 Background: Successful treatment of patients with colorectal peritoneal carcinomatosis highly depends on complete surgical tumor resection of all tumor. Oncological outcomes can potentially be improved by intraoperative imaging using a tumor-targeting antibody conjugated to a fluorophore and a radiotracer. This enables preoperative radionuclide imaging, real-time intraoperative fluorescence imaging and gamma detection. In this study we investigate the feasibility, accuracy and safety of CEA-targeted preoperative SPECT/CT and intraoperative fluorescence imaging in patients with colorectal PC. Methods: In this phase I/II single arm protein dose escalation study patients with peritoneal metastases of colorectal origin who are scheduled for cytoreductive surgery and HIPEC will receive an intravenous injection of the CEA-targeting tracer 111In-DOTA-labetuzumab-IRDye800CW. The first 15 patients will receive a single dose of 2,10 or 50 mg 6 to 7 days prior to surgery. Four to five days after injection SPECT/CT imaging of the thorax and abdomen is performed to determine intra-abdominal tumor load and detect extra-abdominal metatases. At day 6/7 after injection, standard cytoreductive surgical resection extended with real-time near-infrared fluorescence imaging and radio guidance is performed. After surgery, the peritoneal cavity will be re-examined for residual disease with fluorescence imaging. Resected specimens are analyzed microscopically, immunohistochemically (CEA and H&E) and by gamma counting. Blood samples are drawn for farmacokinetics and safety analysis at 180 minutes, 4 days, 6 days and 3 weeks after tracer injection. In the phase II dose expansion cohort, 14 more patients will receive the optimal dose as determined in the phase I trial. The primary objectives of the trial are to assess the safety, feasibility and accuracy of preoperative SPECT/CT and intraoperative fluorescence imaging after administration of 111In- labetuzumab-IRDye800CW in patients with peritoneal carcinomatosis of colorectal origin who will undergo cytoreductive surgery and HIPEC. The secondary objectives are to assess whether additional malignant lesions can be visualized by fluorescence imaging after cytoreductive surgery, to assess the intensity of fluorescence in malignant and non-malignant tissue, to assess the correlation between localization of the dual-labeled antibody and CEA expression in tumor and healthy tissue and to determine blood concentrations of the dual labelled antibody at several time points in patients. Clinical trial information: NCT03699332 .

Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging

Biomaterials ◽  
2010 ◽  
Vol 31 (26) ◽  
pp. 6823-6832 ◽  
Author(s):  
Patrick T.K. Chin ◽  
Tessa Buckle ◽  
Arantxa Aguirre de Miguel ◽  
Stefan C.J. Meskers ◽  
René A.J. Janssen ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery

2008 ◽  
Vol 15 (5) ◽  
pp. 508-514 ◽  
Author(s):  
Noboru Mitsuhashi ◽  
Fumio Kimura ◽  
Hiroaki Shimizu ◽  
Mizuho Imamaki ◽  
Hiroyuki Yoshidome ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Hepatobiliary Surgery ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

scholarly journals Intraoperative fluorescence imaging in thoracic surgery

2018 ◽  
Vol 118 (2) ◽  
pp. 344-355 ◽  
Author(s):  
Andrew D. Newton ◽  
Jarrod D. Predina ◽  
Shuming Nie ◽  
Philip S. Low ◽  
Sunil Singhal
Keyword(s):  
Thoracic Surgery ◽  
Fluorescence Imaging ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence
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