Prognostic significance of the expression of vascular endothelial growth factors A, B, C, and D and their receptors R1, R2, and R3 in patients with nonsmall cell lung cancer

Cancer ◽  
2009 ◽  
Vol 115 (8) ◽  
pp. 1701-1712 ◽  
Author(s):  
Enrique Carrillo de Santa Pau ◽  
Fernando Carrillo Arias ◽  
Enrique Caso Peláez ◽  
Gemma María Muñoz Molina ◽  
Ignacio Sánchez Hernández ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factors ◽  
Cell Lung Cancer ◽  
Prognostic Significance ◽  
Nonsmall Cell Lung Cancer ◽  
Vascular Endothelial Growth Factors ◽  
Vascular Endothelial ◽  
Endothelial Growth Factors

scholarly journals Study of Microvessel Density and the Expression of Vascular Endothelial Growth Factors in Adrenal Gland Pheochromocytomas

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Magdalena Białas ◽  
Grzegorz Dyduch ◽  
Joanna Dudała ◽  
Monika Bereza-Buziak ◽  
Alicja Hubalewska-Dydejczyk ◽  
...  
Keyword(s):  
Growth Factors ◽  
Microvessel Density ◽  
Antiangiogenic Therapy ◽  
Prognostic Significance ◽  
Operation Technique ◽  
Vascular Endothelial Growth Factors ◽  
Vascular Endothelial ◽  
Vascular Architecture ◽  
Laparoscopic Operation ◽  
Endothelial Growth Factors

Angiogenesis (neoangiogenesis), a process of neovascularization, is an essential step for local tumor growth and distant metastasis formation. We have analysed angiogenesis status: vascular architecture, microvessel density, and vascular endothelial growth factors expression in 62 adrenal pheochromocytomas: 57 benign and 5 malignant. Immunohistochemical evaluation revealed that vascular architecture and vessel density are different in the central and subcapsular areas of the tumor. Furthermore, we have observed a strong correlation between number of macrophages and microvessel density in the central and subcapsular areas of the tumor and between the expression of VEGF-A in tumor cells and microvessel density in central and subcapsular areas of the tumor. Secondary changes in these tumors influence the results and both vascular architecture and microvessel density are markedly disturbed by hemorrhagic and cystic changes in pheochromocytomas. These changes are partially caused by laparoscopic operation technique. However, no differences in vascular parameters were found between pheochromocytomas with benign and malignant clinical behavior. Our observation showed that analysis of angiogenesis, as a single feature, does not help in differentiating malignant and benign pheochromocytomas and has no independent prognostic significance. On the other hand, high microvessel density in pheochromocytoma is a promising factor for antiangiogenic therapy in malignant cases.

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