scholarly journals Pathologic T1 clear cell renal cell carcinoma: Insulin-like growth factor-I receptor expression and disease-specific survival

Cancer ◽  
2004 ◽  
Vol 100 (12) ◽  
pp. 2577-2582 ◽  
Author(s):  
Alexander S. Parker ◽  
John C. Cheville ◽  
Michael L. Blute ◽  
Todd Igel ◽  
Christine M. Lohse ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Receptor Expression ◽  
Disease Specific Survival ◽  
Cell Renal Cell Carcinoma ◽  
Factor I ◽  
Disease Specific

Karyotyping of resected clear cell renal cell carcinoma: Loss of chromosome 4 predicts a worse disease-specific survival

2018 ◽  
Vol 17 (2) ◽  
pp. e71
Author(s):  
M.W. Van Hattem ◽  
L. Renkens ◽  
M. Debiec-Rychter ◽  
J. Berkers ◽  
B. Van Cleynenbreugel ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Disease Specific Survival ◽  
Chromosome 4 ◽  
Cell Renal Cell Carcinoma ◽  
Disease Specific

scholarly journals KDF1, a Novel Tumor Suppressor in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Jing-min Zheng ◽  
Mei-fu Gan ◽  
Hong-yuan Yu ◽  
Lu-xia Ye ◽  
Qing-xin Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Suppressor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Tissue ◽  
Clear Cell ◽  
Expression Level ◽  
Disease Specific Survival ◽  
Cell Renal Cell Carcinoma ◽  
Disease Specific

KDF1 has been identified as a key regulator of epidermal proliferation and differentiation, but it is unknown whether KDF1 is involved in the pathogenesis of malignancy. No study has reported the expression and function of KDF1 in renal cancer. To explore the pathologic significance of KDF1 in clear cell renal cell carcinoma (ccRCC), the expression level of KDF1 protein in the tumor tissue of ccRCC patients was examined by immunohistochemistry and Western blot while the expression level of KDF1 mRNA was analyzed by using the data from TCGA database. In vitro cell experiments and allogeneic tumor transplantation tests were performed to determine the effects of altered KDF1 expression on the phenotype of ccRCC cells. Both the KDF1 mRNA and protein were found to be decreasingly expressed in the tumor tissue of ccRCC patients when compared with the adjacent non-tumor control tissue. The expression level of KDF1 in the tumor tissue was found to correlate negatively with the tumor grade. Patients with higher KDF1 in the tumor tissue were found to have longer overall survival and disease-specific survival time. KDF1 was shown to be an independent factor influencing the disease-specific survival of the ccRCC patients. Overexpression of KDF1 was found to inhibit the proliferation, migration and invasion of ccRCC cells, which could be reversed by decreasing the expression of KDF1 again. ccRCC cells with KDF1 overexpression were found to produce smaller transgrafted tumors. These results support the idea that KDF1 is involved in ccRCC and may function as a tumor suppressor.

Expression of Insulin-like Growth Factor I Receptor and Survival in Patients with Clear Cell Renal Cell Carcinoma

2003 ◽  
Vol 170 (2) ◽  
pp. 420-424 ◽  
Author(s):  
ALEXANDER S. PARKER ◽  
JOHN C. CHEVILLE ◽  
CHRISTINE LOHSE ◽  
JAMES R. CERHAN ◽  
MICHAEL L. BLUTE
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Insulin Like Growth Factor ◽  
Cell Renal Cell Carcinoma ◽  
Factor I ◽  
Growth Factor I

scholarly journals Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (24) ◽  
pp. 35917-35931 ◽  
Author(s):  
Raviprakash T. Sitaram ◽  
Pramod Mallikarjuna ◽  
Maréne Landström ◽  
Börje Ljungberg
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Transforming Growth Factor ◽  
Clear Cell ◽  
Transforming Growth Factor Β ◽  
Cell Renal Cell Carcinoma
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