Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma

2013 ◽  
Vol 112 (4) ◽  
pp. E415-E423 ◽  
Author(s):  
Lifeng Qi ◽  
Jun Du ◽  
Zhenting Zhang ◽  
Lei Diao ◽  
Xusheng Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Distant Metastasis ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Platelet Derived Growth Factor ◽  
Cell Renal Cell Carcinoma ◽  
Low Expression

Low Expression of ATM Indicates a Poor Prognosis in Clear Cell Renal Cell Carcinoma

2019 ◽  
Vol 17 (3) ◽  
pp. e433-e439 ◽  
Author(s):  
Wenbiao Ren ◽  
Bichen Xue ◽  
Minfeng Chen ◽  
Longfei Liu ◽  
Xiongbing Zu
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Low Expression

scholarly journals Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Fafen Yang ◽  
Jingjie Zhao ◽  
Xiuzhuang Luo ◽  
Tong Li ◽  
Zechen Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Distant Metastasis ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Immune Cell ◽  
Clear Cell ◽  
Immune Therapy ◽  
Cell Renal Cell Carcinoma

Although immune therapy can improve the treatment of clear cell renal cell carcinoma (ccRCC) significantly, there are still a large proportion of ccRCC patients who progress to metastasis. Targeting the pro-metastatic immune cell in the ccRCC microenvironment could provide a solution to this problem. In this study, B cells in ccRCC biopsies were identified by using scRNA-seq and flow cytometry. The findings indicated the presence of a pro-metastatic B cell type which could be further classified into 3 subpopulations, MARCH3, B2M and DTWD1, based on their large-scaled genetic profiles, rather than traditional Immature/Mature ones. Although all of the 3 subpopulations appeared to contribute to distant metastasis, B cell (B2M) was deemed to be the most essential. Moreover, STX16, CLASRP, ATIC, ACIN1 and SEMA4B, were genes found to be commonly up-regulated in the 3 subpopulations and this was correlated to a poor prognosis of ccRCC. Furthermore, the heterogeneity of plasma cells in ccRCC was also found to contribute to metastasis of the disease. This study offers potential novel therapeutic targets against distant metastasis of cancers, and can help to improve the therapeutic efficiency of ccRCC patients.

scholarly journals The Prognostic Significance of Protein Expression of CASZ1 in Clear Cell Renal Cell Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Bohyun Kim ◽  
Minsun Jung ◽  
Kyung Chul Moon
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Size ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Prognostic Significance ◽  
Cell Renal Cell Carcinoma ◽  
Low Expression ◽  
T Category

Backgrounds. Clear cell renal cell carcinoma (ccRCC) is the most common histologic subtype of renal cell carcinoma (RCC) and shows a relatively poor prognosis among RCCs. Castor zinc finger 1 (CASZ1) is a transcription factor, prominently known for its tumor suppression role in neuroblastoma and other cancers. However, there has been no research about the prognostic significance of CASZ1 in ccRCC. In this study, we investigated CASZ1 expression in ccRCC and analyzed its prognostic implications. Methods. A total of 896 ccRCC patients, who underwent surgical resection from 1995 to 2008, were included. We prepared tissue microarray blocks, evaluated CASZ1 nuclear expression by immunohistochemistry, and classified the cases into low or high expression categories. Results. A low expression of CASZ1 was observed in 320 cases (35.7%) and was significantly associated with large tumor size, high World Health Organization/International Society of Urological Pathology (WHO/ISUP) grade, and high T category and M category. In survival analysis, a low expression of CASZ1 was significantly correlated with unfavorable progression-free survival (PFS) (p<0.001), overall survival (OS) (p<0.001), and cancer-specific survival (CSS) (p<0.001) and was an independent prognostic factor for PFS and CSS in multivariate analysis adjusted for tumor size, WHO/ISUP grade, T category, N category, and M category. Conclusions. Our study is the first to show the prognostic significance of CASZ1 expression in ccRCC. Our results revealed that low expression of CASZ1 is associated with poor prognosis and may serve as a new prognostic indicator.

scholarly journals Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma

Medicine ◽  
2016 ◽  
Vol 95 (17) ◽  
pp. e3225 ◽  
Author(s):  
Hangcheng Fu ◽  
Yidong Liu ◽  
Le Xu ◽  
Yuan Chang ◽  
Lin Zhou ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Low Expression
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