scholarly journals Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells

Cancer ◽  
2003 ◽  
Vol 98 (11) ◽  
pp. 2511-2520 ◽  
Author(s):  
Joann Zhang ◽  
Jocelyn C. Hsu B.A. ◽  
Matthew A. Kinseth B.A. ◽  
Leonard F. Bjeldanes ◽  
Gary L. Firestone
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Prostate Specific Antigen ◽  
Prostate Carcinoma ◽  
Specific Antigen ◽  
Carcinoma Cells ◽  
Antigen Production ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Marine Drugs ◽  
2017 ◽  
Vol 15 (6) ◽  
pp. 154 ◽  
Author(s):  
Hye Park ◽  
Shin-Hyung Park ◽  
Jin-Woo Jeong ◽  
Dahye Yoon ◽  
Min Han ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Human Colorectal Carcinoma

scholarly journals Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference

Oncogene ◽  
2003 ◽  
Vol 22 (54) ◽  
pp. 8653-8661 ◽  
Author(s):  
Carsten Denkert ◽  
Antje Fürstenberg ◽  
Peter Ted Daniel ◽  
Ines Koch ◽  
Martin Köbel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Rna Interference ◽  
Ovarian Carcinoma ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Inflammatory Drug ◽  
Cycle Arrest ◽  
Ovarian Carcinoma Cells ◽  
G1 Cell Cycle Arrest ◽  
Cox 2

scholarly journals Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

Blood ◽  
1998 ◽  
Vol 91 (2) ◽  
pp. 458-465 ◽  
Author(s):  
Bernard W. Parker ◽  
Gurmeet Kaur ◽  
Wilberto Nieves-Neira ◽  
Mohammed Taimi ◽  
Glenda Kohlhagen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Lines ◽  
Prostate Carcinoma ◽  
Cell Types ◽  
Carcinoma Cells ◽  
Cycle Arrest ◽  
Induced Apoptosis ◽  
Different Cell Types ◽  
Hematopoietic Cell Lines

Abstract Flavopiridol (NSC 649890; Behringwerke L86-8275, Marburg, Germany), is a potent inhibitor of cyclin dependent kinases (CDKs) 1, 2, and 4. It has potent antiproliferative effects in vitro and is active in tumor models in vivo. While surveying the effect of flavopiridol on cell cycle progression in different cell types, we discovered that hematopoietic cell lines, including SUDHL4, SUDHL6 (B-cell lines), Jurkat, and MOLT4 (T-cell lines), and HL60 (myeloid), displayed notable sensitivity to flavopiridol-induced apoptosis. For example, after 100 nmol/L for 12 hours, SUDHL4 cells displayed a similar degree of DNA fragmentation to that shown by the apoptosis-resistant PC3 prostate carcinoma cells only after 3,000 nmol/L for 48 hours. After exposure to 1,000 nmol/L flavopiridol for 12 hours, typical apoptotic morphology was observed in SUDHL4 cells, but not in PC3 prostate carcinoma cells despite comparable potency (SUDHL4:120 nmol/L; PC3: 203 nmol/L) in causing growth inhibition by 50% (IC50). Flavopiridol did not induce topoisomerase I or II cleavable complex activity. A relation of p53, bcl2, or bax protein levels to apoptosis in SUDHL4 was not appreciated. While flavopiridol caused cell cycle arrest with decline in CDK1 activity in PC3 cells, apoptosis of SUDHL4 cells occurred without evidence of cell cycle arrest. These results suggest that antiproliferative activity of flavopiridol (manifest by cell cycle arrest) may be separated in different cell types from a capacity to induce apoptosis. Cells from hematopoietic neoplasms appear in this limited sample to be very susceptible to flavopiridol-induced apoptosis and therefore clinical trials in hematopoietic neoplasms should be of high priority.

Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells

2012 ◽  
Vol 23 (6) ◽  
pp. 606-613 ◽  
Author(s):  
Zhongyong Jiang ◽  
Jin Chai ◽  
Henry Hon Fung Chuang ◽  
Shifeng Li ◽  
Tianran Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Epidermoid Carcinoma ◽  
Mitochondrial Apoptosis ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Human Epidermoid Carcinoma
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