scholarly journals Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow

2006 ◽  
Vol 1 (6) ◽  
pp. 259-266 ◽  
Author(s):  
A. L. Klibanov ◽  
J. J. Rychak ◽  
W. C. Yang ◽  
S. Alikhani ◽  
B. Li ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Shear Flow ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
High Shear ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

scholarly journals CMR 2005: 8.03: Targeted ultrasound contrast agents for molecular imaging in high-shear flow

2006 ◽  
Vol 1 (2) ◽  
pp. 74-74
Author(s):  
A.L. Klibanov ◽  
J.J. Rychak ◽  
W.C. Yang ◽  
B. Li ◽  
S. Acton ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Shear Flow ◽  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
High Shear ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

BR55: A Lipopeptide-Based VEGFR2-Targeted Ultrasound Contrast Agent for Molecular Imaging of Angiogenesis

2010 ◽  
Vol 45 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Sibylle Pochon ◽  
Isabelle Tardy ◽  
Philippe Bussat ◽  
Thierry Bettinger ◽  
Jean Brochot ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

Selectin Ligands Promote Ultrasound Contrast Agent Adhesion under Shear Flow

2006 ◽  
Vol 3 (5) ◽  
pp. 516-524 ◽  
Author(s):  
J. J. Rychak ◽  
B. Li ◽  
S. T. Acton ◽  
A. Leppänen ◽  
R. D. Cummings ◽  
...  
Keyword(s):  
Shear Flow ◽  
Contrast Agent ◽  
Ultrasound Contrast Agent ◽  
Ultrasound Contrast ◽  
Selectin Ligands

In Vitro Evaluation of Ultrasound-Assisted Thrombolysis Using a Targeted Ultrasound Contrast Agent

2009 ◽  
Vol 31 (4) ◽  
pp. 235-246 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jia-Ling Ruan ◽  
Po-Wen Cheng ◽  
Yueh-Hsun Chuang ◽  
Pai-Chi Li
Keyword(s):  
Contrast Agent ◽  
Weight Reduction ◽  
Ultrasound Contrast Agent ◽  
High Frequency Ultrasound ◽  
Ultrasound Frequency ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound ◽  
Targeted Microbubbles ◽  
Ultrasound Assisted

A thrombus-targeted ultrasound contrast agent bound with tirofiban — a glycoprotein (GP) IIb/IIIa antagonist that can specifically bind to activated platelets in the thrombus — was designed to enhance both the image contrast and thrombolysis effect. In this study, we used 76 canine thrombi for investigation. The targeting ability to thrombi was confirmed by microphotography and high-frequency ultrasound (40 MHz) imaging. The effect of the targeted microbubbles on thrombolysis enhancement was investigated using an in vitro flow system: targeted and nontargeted microbubbles flowed through the clot for 30 seconds with a washing step; the microbubbles remained on the clot that were then cavitated by ultrasound (frequency = 1 MHz, MI = 1.2). The extent of thrombolysis was evaluated by weight reduction and histology analysis. The targeted microbubbles reduced the weight of thrombi by a factor of 1.7 times that of the nontargeted microbubbles. (clot weight reduction: 23.1 ± 5.3% versus 13.6 ± 4.9%, p < 0.01 between targeted and nontargeted group), and the signal enhancement was 3.34 ± 0.30 dB (mean ± SD, p < 0.01 compared to control). We conclude that targeted microbubbles are applicable not only for molecular imaging of thrombi but also for improving the effectiveness of ultrasound-assisted thrombolysis.

scholarly journals RGD-Targeted Ultrasound Contrast Agent for Longitudinal Assessment of Hep-2 Tumor Angiogenesis In Vivo

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149075 ◽  
Author(s):  
Qiao Hu ◽  
Xiao-Yan Wang ◽  
Li-Ke Kang ◽  
Hai-Ming Wei ◽  
Chun-Mei Xu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Ultrasound Contrast Agent ◽  
Longitudinal Assessment ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound
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