Synthesis of α-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases

ChemMedChem ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Jan Frydrych ◽  
Jan Skácel ◽  
Markéta Šmídková ◽  
Helena Mertlíková-Kaiserová ◽  
Martin Dračínský ◽  
...  
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Potential Inhibitors

Efficient one-pot synthesis of polysubstituted 6-[(1H-1,2,3-triazol-1-yl)methyl]uracils through the “click” protocol

2011 ◽  
Vol 76 (9) ◽  
pp. 1121-1131 ◽  
Author(s):  
Petr Jansa ◽  
Petr Špaček ◽  
Ivan Votruba ◽  
Petra Břehová ◽  
Martin Dračínský ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Inhibitory Activity ◽  
Thymidine Phosphorylase ◽  
Room Temperature ◽  
One Pot ◽  
Decarboxylation Reaction ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Potential Inhibitors ◽  
Substituted 1

The preparation of several triazolo acyclic nucleosides and triazolo acyclic nucleoside phosphonates is described. The synthetic methodology has been developed as an efficient one-pot Cu(I)-catalyzed azide alkyne Huisgen “click” cycloaddition. A novel Cu(I)-catalyzed decarboxylation reaction of 1-substituted 1H-1,2,3-triazole-4-carboxylic acids at room temperature was observed and used for the preparation of 1-substituted 1H-1,2,3-triazoles. As congeners of TPI (Taiho pharmaceutical inhibitor), the prepared compounds were screened as potential inhibitors of human thymidine phosphorylase, but no inhibitory activity was observed.

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

scholarly journals In-silico designing of acyclic nucleoside phosphonates and their anti-HIV potential

2012 ◽  
Vol 12 (Suppl 1) ◽  
pp. P3
Author(s):  
Dipti Yadav ◽  
Anuradha Singh ◽  
Madhu Yadav ◽  
Ramendra K Singh
Keyword(s):  
In Silico ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Anti Hiv

scholarly journals Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety

Tetrahedron ◽  
2019 ◽  
Vol 75 (39) ◽  
pp. 130529 ◽  
Author(s):  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Radek Pohl ◽  
Robert Snoeck ◽  
Graciela Andrei
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Base Moiety
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