Calcium Coordination Solids for pH-Triggered Release of Olsalazine

Dana J. Levine; Miguel I. Gonzalez; Christina M. Legendre; Tomče Runčevski; Julia Oktawiec; Kristen A. Colwell; Jeffrey R. Long

doi:10.1002/cmdc.201700540

Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review

Current Cancer Therapy Reviews ◽

10.2174/1573394716999201228215537 ◽

2020 ◽

Vol 16 ◽

Author(s):

Ali Ahmadi ◽

Hadi Esmaeili Gouvarchin Ghaleh ◽

Ruhollah Dorostkar ◽

Mahdieh Farzanehpour ◽

Masoumeh Bolandian

Keyword(s):

Genetic Disease ◽

Control Cell ◽

Gene Mutations ◽

Therapeutic Agents ◽

Cell Penetrating Peptides ◽

Triggered Release ◽

New Techniques ◽

Viral Therapy ◽

Cell Penetrating ◽

Cancer Cell Targeting

Abstract:: Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechnological technique for turning viruses into therapeutic agents by the reprogramming of viruses to cure diseases. In several tumors, including melanoma, multiple myeloma, bladder cancer, and breast cancer, the oncolytic capacity of oncolytic Coxsackievirus has been studied. The present study aims to assess oncolytic Coxsackievirus and its mechanisms of effect on cancer cells.

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Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽

10.3390/pharmaceutics13060858 ◽

2021 ◽

Vol 13 (6) ◽

pp. 858

Author(s):

Kyriaki-Marina Lyra ◽

Archontia Kaminari ◽

Katerina N. Panagiotaki ◽

Konstantinos Spyrou ◽

Sergios Papageorgiou ◽

...

Keyword(s):

Carbon Nanotubes ◽

Anticancer Activity ◽

Cancer Cells ◽

Delivery System ◽

Colloidal Stability ◽

Triggered Release ◽

Selective Toxicity ◽

Molecular Transporters ◽

Multi Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

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Hydrogel Microcapsules: Hydrogel Microcapsules with a Thin Oil Layer: Smart Triggered Release via Diverse Stimuli (Adv. Funct. Mater. 18/2021)

Advanced Functional Materials ◽

10.1002/adfm.202170124 ◽

2021 ◽

Vol 31 (18) ◽

pp. 2170124

Author(s):

Hye‐Seon Jeong ◽

Eunseo Kim ◽

Changwoo Nam ◽

Yoon Choi ◽

You‐Jeong Lee ◽

...

Keyword(s):

Triggered Release

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Molecular Study of Ultrasound-Triggered Release of Fluorescein from Liposomes

Langmuir ◽

10.1021/acs.langmuir.0c03444 ◽

2021 ◽

Vol 37 (13) ◽

pp. 3868-3881

Author(s):

Fatima El Hajj ◽

Patrick F. J. Fuchs ◽

Wladimir Urbach ◽

Mohammad Nassereddine ◽

Salah Hamieh ◽

...

Keyword(s):

Molecular Study ◽

Triggered Release

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Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

RSC Advances ◽

10.1039/d0ra08893e ◽

2021 ◽

Vol 11 (15) ◽

pp. 8546-8551

Author(s):

Johannes Karcher ◽

Susanne Kirchner ◽

Anna-Lena Leistner ◽

Christian Hald ◽

Philipp Geng ◽

...

Keyword(s):

Anticancer Agent ◽

Green Light ◽

Supramolecular Hydrogel ◽

Triggered Release ◽

Physiological Conditions

Selective green-light triggered release of an anticancer agent under physiological conditions from a supramolecular hydrogel.

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Oxidation and ATP dual-responsive block copolymer containing tertiary sulfoniums: self-assembly, protein complexation and triggered release

Polymer Chemistry ◽

10.1039/d0py01622e ◽

2021 ◽

Author(s):

Yanfen Jiang ◽

Shuqi Dong ◽

Guoyang Qin ◽

Li Liu ◽

Hanying Zhao

Keyword(s):

Block Copolymer ◽

Self Assembly ◽

Phenylboronic Acid ◽

Cationic Polymer ◽

Release Profile ◽

Triggered Release ◽

Dual Responsive ◽

Protein Complexation

Alkylation of thioether-containing block copolymer simultaneously incorporated sulfoniums and phenylboronic acid moieties. The co-assembly of this cationic polymer and protein generated micelles with an H2O2-and ATP-responsive release profile.

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Sunlight-Activated Phase Change Materials for Controlled Heat Storage and Triggered Release

Journal of Materials Chemistry A ◽

10.1039/d1ta01007g ◽

2021 ◽

Author(s):

Yuran Shi ◽

Mihael Gerkman ◽

Qianfeng Qiu ◽

Shuren Zhang ◽

Grace G. D. Han

Keyword(s):

Phase Transition ◽

Solar Radiation ◽

Phase Change ◽

Latent Heat ◽

Photon Energy ◽

Organic Phase ◽

Phase Change Materials ◽

Heat Storage ◽

Triggered Release

We report the design of photo-responsive organic phase change materials that can absorb filtered solar radiation to store both latent heat and photon energy via simultaneous phase transition and photo-isomerization....

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Dendritic magnetite decorated by pH-responsive PEGylated starch: a smart multifunctional nanocarrier for the triggered release of anti-cancer drugs

RSC Advances ◽

10.1039/c5ra04040j ◽

2015 ◽

Vol 5 (60) ◽

pp. 48586-48595 ◽

Cited By ~ 11

Author(s):

Ali Pourjavadi ◽

Zahra Mazaheri Tehrani ◽

Seyed Hassan Hosseini

Keyword(s):

Acrylic Acid ◽

Cancer Drugs ◽

Ph Responsive ◽

Triggered Release ◽

Anti Cancer ◽

Poly Acrylic Acid

In the present study, we designed a pH-responsive drug nanocarrier based on polyamidoamine-modified Fe3O4 nanoparticles coated by PEGylated starch-co-poly(acrylic acid).

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