Design and Synthesis of Tricyclic JAK3 Inhibitors with Picomolar Affinities as Novel Molecular Probes

ChemMedChem ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Matthias Gehringer ◽  
Ellen Pfaffenrot ◽  
Silke Bauer ◽  
Stefan A. Laufer
Keyword(s):  
Molecular Probes ◽  
Design And Synthesis

scholarly journals Design and synthesis of active heparan sulfate-based probes

2015 ◽  
Vol 51 (55) ◽  
pp. 11019-11021 ◽  
Author(s):  
Wen Zhou ◽  
Po-Hung Hsieh ◽  
Yongmei Xu ◽  
Timothy R. O’Leary ◽  
Xuefei Huang ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Molecular Probes ◽  
Design And Synthesis ◽  
Sulfated Carbohydrate ◽  
Specific Inhibitors

Synthesis of sulfated carbohydrate molecular probes and the utilities as specific inhibitors for carbohydrate sulfotransferases.

scholarly journals Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel

2014 ◽  
Vol 24 (11) ◽  
pp. 2469-2472 ◽  
Author(s):  
Lalit Kumar Sharma ◽  
Pauline M. Cupit ◽  
Tino Goronga ◽  
Thomas R. Webb ◽  
Charles Cunningham
Keyword(s):  
Molecular Probes ◽  
Anthelmintic Drug ◽  
Design And Synthesis

Design And Synthesis Of Dual-Affinity Molecular Probes Targeting The Opioid Receptors

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
AW Keasling ◽  
IA Khan ◽  
BL Roth ◽  
JK Zjawiony
Keyword(s):  
Opioid Receptors ◽  
Molecular Probes ◽  
Design And Synthesis

scholarly journals Design and assembly of supramolecular dual-modality nanoprobes

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9462-9466 ◽  
Author(s):  
Shuang Liu ◽  
Pengcheng Zhang ◽  
Sangeeta Ray Banerjee ◽  
Jiadi Xu ◽  
Martin G. Pomper ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Metal Ion ◽  
Molecular Probes ◽  
Dual Modality ◽  
Design And Synthesis ◽  
Self Assembling

We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods.

scholarly journals Strigolactone Analogs as Molecular Probes in Chasing the (SLs) Receptor/s: Design and Synthesis of Fluorescent Labeled Molecules

2013 ◽  
Vol 6 (1) ◽  
pp. 113-127 ◽  
Author(s):  
Cristina Prandi ◽  
Helèna Rosso ◽  
Beatrice Lace ◽  
Ernesto G. Occhiato ◽  
Alberto Oppedisano ◽  
...  
Keyword(s):  
Molecular Probes ◽  
Design And Synthesis

scholarly journals Design and synthesis of specific molecular probes for prostaglandin receptor signaling

1997 ◽  
Vol 73 ◽  
pp. 20
Author(s):  
M. Suzuki ◽  
K. Kato ◽  
H. Doi ◽  
M. Björkman ◽  
K. Furuta ◽  
...  
Keyword(s):  
Molecular Probes ◽  
Receptor Signaling ◽  
Design And Synthesis ◽  
Prostaglandin Receptor

scholarly journals Back Cover: Design and Synthesis of Tricyclic JAK3 Inhibitors with Picomolar Affinities as Novel Molecular Probes (ChemMedChem 2/2014)

ChemMedChem ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. 412-412
Author(s):  
Matthias Gehringer ◽  
Ellen Pfaffenrot ◽  
Silke Bauer ◽  
Stefan A. Laufer
Keyword(s):  
Molecular Probes ◽  
Back Cover ◽  
Design And Synthesis ◽  
Cover Design

scholarly journals MICROWAVE-ASSISTED SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF NOVEL PYRIDINE-BASED FLUORESCENT MOLECULAR PROBES

2019 ◽  
Author(s):  
Pawel Fiedor ◽  
Joanna Ortyl ◽  
Mariusz Galek
Keyword(s):  
High Sensitivity ◽  
Spectroscopic Properties ◽  
Heating Time ◽  
Molecular Probes ◽  
Microwave Assisted Synthesis ◽  
Design And Synthesis ◽  
Analytical Tools ◽  
Fluorescent Molecular Probes ◽  
Derivatives Of

Fluorescent molecular probes become interesting analytical tools in determination and labeling of chemical compounds and physical properties such as viscosity and polarity. Currently known fluorescent molecular probes can selectively and regardless of the environment detect only few molecules, and applicability in determination of micro- viscosity and micro-polarity are limited to narrow range and specific condition, therefore design and synthesis of novel molecular probes with extended range of operation are highly needed [1]. Traditional synthesis of 2-amino-4,6-diphenyl-pyridine-3-carbonitrile’s requires two step reaction with long heating time or and toxic solvent. By application of microwave irradiation, reaction time can be firmly shortened with the same or higher efficiency [2]. Derivatives of 2-amino-4,6-diphenyl-pyridine-3-carbonitrile can find application in different fields of science. Depending on the structure of fluorophore, those compounds exhibit high sensitivity to changes in polarity and viscosity of environment, also concentration of specific cations, and pH can be determined by measuring of fluorescence spectrum.

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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