Predicting Drug Metabolism by Cytochrome P450 2C9: Comparison with the 2D6 and 3A4 Isoforms

ChemMedChem ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. 1202-1209 ◽  
Author(s):  
Patrik Rydberg ◽  
Lars Olsen
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 2C9

Cytochrome P450 enzyme functionalized-quantum dots as photocatalysts for drug metabolism

2014 ◽  
Vol 50 (57) ◽  
pp. 7607-7610 ◽  
Author(s):  
Xuan Xu ◽  
Jing Qian ◽  
Jiachao Yu ◽  
Yuanjian Zhang ◽  
Songqin Liu
Keyword(s):  
Quantum Dots ◽  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 Enzyme ◽  
Cytochrome P450 2C9 ◽  
Cdte Qds ◽  
P450 Enzyme

A light-controlled drug metabolism system was successfully designed by using cytochrome P450 2C9 (CYP2C9) functionalized CdTe QDs as photocatalysts.

Flavonoids Diosmetin and Hesperetin are Potent Inhibitors of Cytochrome P450 2C9-mediated Drug Metabolism in vitro

2010 ◽  
Vol 25 (5) ◽  
pp. 466-476 ◽  
Author(s):  
Luigi Quintieri ◽  
Sara Bortolozzo ◽  
Stefano Stragliotto ◽  
Stefano Moro ◽  
Martina Pavanetto ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome P450 2C9

Predicting Drug Metabolism:  A Site of Metabolism Prediction Tool Applied to the Cytochrome P450 2C9

2003 ◽  
Vol 46 (12) ◽  
pp. 2313-2324 ◽  
Author(s):  
Ismael Zamora ◽  
Lovisa Afzelius ◽  
Gabriele Cruciani
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Prediction Tool ◽  
Cytochrome P450 2C9 ◽  
A Site

scholarly journals Quantum Mechanics/Molecular Mechanics Modeling of Regioselectivity of Drug Metabolism in Cytochrome P450 2C9

2013 ◽  
Vol 135 (21) ◽  
pp. 8001-8015 ◽  
Author(s):  
Richard Lonsdale ◽  
Kerensa T. Houghton ◽  
Jolanta Żurek ◽  
Christine M. Bathelt ◽  
Nicolas Foloppe ◽  
...  
Keyword(s):  
Quantum Mechanics ◽  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Molecular Mechanics ◽  
Cytochrome P450 2C9

Biology of Heme: Drug Interactions and Adverse Drug Reactions with CYP450

2019 ◽  
Vol 18 (23) ◽  
pp. 2042-2055 ◽  
Author(s):  
Neeraj Kumar ◽  
Heerak Chugh ◽  
Damini Sood ◽  
Snigdha Singh ◽  
Aarushi Singh ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Genetic Defects ◽  
Drug Reactions ◽  
Detailed Structure ◽  
Synthesis And Degradation ◽  
Porphyrin Rings

Heme is central to functions of many biologically important enzymes (hemoproteins). It is an assembly of four porphyrin rings joined through methylene bridges with a central Fe (II). Heme is present in all cells, and its synthesis and degradation balance its amount in the cell. The deregulations of heme networks and incorporation in hemoproteins lead to pathogenic state. This article addresses the detailed structure, biosynthesis, degradation, and transportation associated afflictions to heme. The article is followed by its roles in various diseased conditions where it is produced mainly as the cause of increased hemolysis. It manifests the symptoms in diseases as it is a pro-oxidant, pro-inflammatory and pro-hemolytic agent. We have also discussed the genetic defects that tampered with the biosynthesis, degradation, and transportation of heme. In addition, a brief about the largest hemoprotein group of enzymes- Cytochrome P450 (CYP450) has been discussed with its roles in drug metabolism.

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