Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

2012 ◽  
Vol 48 (63) ◽  
pp. 7802 ◽  
Author(s):  
Xuan Xu ◽  
Wei Wei ◽  
Minghe Huang ◽  
Li Yao ◽  
Songqin Liu
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Tin Oxide ◽  
Indium Tin Oxide ◽  
Cytochrome P450 Reductase ◽  
Cytochrome P450 2C9 ◽  
P450 Reductase ◽  
Oxide Nanoparticle ◽  
Nanoparticle Composites

scholarly journals Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5

2011 ◽  
Vol 82 (6) ◽  
pp. 681-691 ◽  
Author(s):  
Rüdiger Kaspera ◽  
Suresh B. Naraharisetti ◽  
Eric A. Evangelista ◽  
Kristin D. Marciante ◽  
Bruce M. Psaty ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Cytochrome B5 ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase

scholarly journals Analysis of X ray diffraction spectra of cholesteryl acrylate-Indium Tin Oxide nanoparticle composites

2019 ◽  
Vol 1402 ◽  
pp. 055074
Author(s):  
A Afrizal ◽  
A Rahman ◽  
E Handoko ◽  
E P Astuti ◽  
L Jati ◽  
...  
Keyword(s):  
Tin Oxide ◽  
Indium Tin Oxide ◽  
X Ray Diffraction ◽  
X Ray ◽  
Oxide Nanoparticle ◽  
Nanoparticle Composites

Fatty Liver and Impaired Hepatic Metabolism Alters the Congener-Specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

2020 ◽  
Author(s):  
Xueshu Li ◽  
Chun-Yun Zhang ◽  
Hans-Joachim Lehmler
Keyword(s):  
Cytochrome P450 ◽  
Polychlorinated Biphenyls ◽  
Fatty Liver ◽  
Partition Coefficients ◽  
Hepatic Metabolism ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Specific Distribution ◽  
Specific Deletion

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are linked to adverse health outcomes. PCB tissue levels are determinants of PCB toxicity; however, it is unclear how factors, such as an altered metabolism and/or a fatty liver, affect PCB distribution in vivo. We determined the congener-specific disposition of PCBs in mice with a liver specific deletion of cytochrome P450 reductase (KO), a model of fatty liver with impaired hepatic metabolism, and wildtype (WT) mice. Male and female KO and WT mice were exposed orally to Aroclor 1254, a technical PCB mixture. PCBs were quantified in adipose, blood, brain and liver tissues by gas chromatography-mass spectrometry. PCB profiles and levels in tissues were genotype and sex dependent. PCB levels were higher in the liver from KO compared to WT mice. PCB profiles showed clear differences between tissues from the same exposure group. While experimental tissue : blood partition coefficients in KO and WT mice did not follow the trends predicted using a composition-based model, the agreement between experimental and calculated partition coefficients was still reasonable. Thus, a fatty liver and/or an impaired hepatic metabolism alter the distribution of PCBs in mice and the magnitude of the partitioning of PCBs from blood into tissues can be approximated using composition-based models.<br>

scholarly journals KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Hypoxia ◽  
2017 ◽  
Vol Volume 5 ◽  
pp. 45-59
Author(s):  
Paolo Lazzari ◽  
Marco Spiga ◽  
Monica Sani ◽  
Matteo Zanda ◽  
Ian N Fleming
Keyword(s):  
Cytochrome P450 ◽  
Cancer Cells ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase
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