Design, Synthesis, and Biological Activity of Hydroxamic Tertiary Amines as Histone Deacetylase Inhibitors

ChemMedChem ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. 694-702 ◽  
Author(s):  
Stefania Terracciano ◽  
Maria Giovanna Chini ◽  
Raffaele Riccio ◽  
Ines Bruno ◽  
Giuseppe Bifulco
Keyword(s):  
Biological Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Tertiary Amines ◽  
Design Synthesis

Design, Synthesis, and Biological Activity of Boronic Acid-Based Histone Deacetylase Inhibitors

2009 ◽  
Vol 52 (9) ◽  
pp. 2909-2922 ◽  
Author(s):  
Nobuaki Suzuki ◽  
Takayoshi Suzuki ◽  
Yosuke Ota ◽  
Tatsuya Nakano ◽  
Masaaki Kurihara ◽  
...  
Keyword(s):  
Biological Activity ◽  
Histone Deacetylase ◽  
Boronic Acid ◽  
Histone Deacetylase Inhibitors ◽  
Design Synthesis

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors

2007 ◽  
Vol 17 (15) ◽  
pp. 4208-4212 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Shinya Hisakawa ◽  
Yukihiro Itoh ◽  
Nobuaki Suzuki ◽  
Katsumasa Takahashi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Folate Receptor ◽  
Design Synthesis

scholarly journals Design, Synthesis, and Blood–Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors

2018 ◽  
Vol 9 (9) ◽  
pp. 884-888 ◽  
Author(s):  
Seiya Hiranaka ◽  
Yuma Tega ◽  
Kei Higuchi ◽  
Toshiki Kurosawa ◽  
Yoshiharu Deguchi ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Blood Brain Barrier ◽  
Histone Deacetylase Inhibitors ◽  
Brain Barrier ◽  
Design Synthesis ◽  
Transport Study ◽  
Blood Brain

scholarly journals Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation

ACS Omega ◽  
2021 ◽  
Vol 6 (7) ◽  
pp. 4907-4920
Author(s):  
Duong T. Anh ◽  
Pham-The Hai ◽  
Le D. Huy ◽  
Hoang B. Ngoc ◽  
Trinh T. M. Ngoc ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors

2019 ◽  
Vol 11 (21) ◽  
pp. 2765-2778
Author(s):  
Jie-Huan Zhang ◽  
Madhusoodanan Mottamal ◽  
Hai-Shan Jin ◽  
Shanchun Guo ◽  
Yan Gu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Active Compound ◽  
Histone Deacetylase Inhibitors ◽  
Hdac Inhibitors ◽  
Antitumor Therapy ◽  
Design Synthesis ◽  
Inhibitory Activities ◽  
Antiproliferative Activities

Aim: Histone deacetylase (HDAC) is an attractive target for antitumor therapy. Therefore, the development of novel HDAC inhibitors is warranted. Materials & methods: A series of HDAC inhibitors based on N-hydroxycinnamamide fragment was designed as the clinically used belinostat analog using amide as the connecting unit. All target compounds were evaluated for their in vitro HDAC inhibitory activities and some selected compounds were tested for their antiproliferative activities. Conclusion: Among them, compound 7e showed an IC50 value of 11.5 nM in inhibiting the HDAC in a pan-HDAC assay, being the most active compound of the series.

Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors

2017 ◽  
Vol 72 ◽  
pp. 32-41 ◽  
Author(s):  
Mamdouh F.A. Mohamed ◽  
Montaser Sh.A. Shaykoon ◽  
Mostafa H. Abdelrahman ◽  
Bakheet E.M. Elsadek ◽  
Ahmed S. Aboraia ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Chalcone Derivatives

Design, synthesis and docking studies on benzamide derivatives as histone deacetylase inhibitors

2011 ◽  
Vol 21 (16) ◽  
pp. 4924-4927 ◽  
Author(s):  
Aijun Lu ◽  
Hongpeng Luo ◽  
Minfeng Shi ◽  
Gang Wu ◽  
Yunxia Yuan ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Docking Studies ◽  
Design Synthesis ◽  
Benzamide Derivatives
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