scholarly journals Crystal Structures of a Second G Protein‐Coupled Receptor: Triumphs and Implications

ChemMedChem ◽  
2008 ◽  
Vol 3 (7) ◽  
pp. 1021-1023 ◽  
Author(s):  
Abby L. Parrill
Keyword(s):  
Crystal Structures ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174719 ◽  
Author(s):  
Thomas Coudrat ◽  
Arthur Christopoulos ◽  
Patrick Michael Sexton ◽  
Denise Wootten
Keyword(s):  
Virtual Screening ◽  
Crystal Structures ◽  
G Protein ◽  
Structural Features ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Identifying G protein-coupled receptor dimers from crystal packings

2018 ◽  
Author(s):  
Ronald E. Stenkamp
Keyword(s):  
Crystal Structures ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled Receptor ◽  
Structural Types ◽  
Resolution Electron ◽  
Receptor Dimers ◽  
G Protein Coupled ◽  
Model Structures ◽  
Crystal Packings

AbstractDimers of G protein-coupled receptors are believed to be important for signaling with their associated G proteins. Low resolution electron microscopy shows rhodopsin dimers in native retinal membranes, and CXCR4 dimers are found in several different crystal structures. Evidence for dimers of other GPCRs is more indirect. An alternative to computational modeling studies is to search for parallel dimers in the packing environments of the reported crystal structures of GPCRs. Two major structural types of GPCR dimers exist (as predicted by others), but there is considerable structural variation within each cluster. The different structural variants described here might reflect different functional properties and should provide a range of model structures for computational and experimental examination.SynopsisAnalysis of intermolecular interactions in G protein-coupled receptor crystal structures shows two major types of dimers.

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