scholarly journals Clinicopathological characteristics of Epstein–Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria

2021 ◽  
Author(s):  
Hiroki Tanabe ◽  
Yusuke Mizukami ◽  
Hidehiro Takei ◽  
Nobue Tamamura ◽  
Yuhi Omura ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
World Health Organization ◽  
Epstein Barr Virus ◽  
Clinicopathological Characteristics ◽  
World Health ◽  
Gastric Neoplasms ◽  
Barr Virus ◽  
The World ◽  
Epstein Barr ◽  
Health Organization

scholarly journals Epstein–Barr Virus-Positive Mucocutaneous Ulcer: A Unique and Curious Disease Entity

2021 ◽  
Vol 22 (3) ◽  
pp. 1053
Author(s):  
Tomoka Ikeda ◽  
Yuka Gion ◽  
Yoshito Nishimura ◽  
Midori Filiz Nishimura ◽  
Tadashi Yoshino ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Malignant Lesion ◽  
B Cell Lymphoma ◽  
Clinicopathological Characteristics ◽  
Good Prognosis ◽  
World Health ◽  
Low Grade ◽  
Barr Virus ◽  
Epstein Barr ◽  
Health Organization

Epstein–Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) was first described as a lymphoproliferative disorder in 2010. EBVMCU is a unifocal mucosal or cutaneous ulcer that often occurs after local trauma in patients with immunosuppression; the patients generally have a good prognosis. It is histologically characterized by proliferating EBV-positive atypical B cells accompanied by ulcers. On the basis of conventional pathologic criteria, EBVMCU may be misdiagnosed as EBV-positive diffuse large B-cell lymphoma or other lymphomas. However, its prognosis differs from that of EBV-associated lymphomas, in that patients with EBVMCU frequently show spontaneous regression or complete remission without chemotherapy. Therefore, EBVMCU is now recognized as a low-grade malignancy or a pseudo-malignant lesion. Avoiding unnecessary chemotherapy by distinguishing EBVMCU from other EBV-associated lymphomas will reduce the burden and unnecessary harm on patients. On the basis of these facts, EBVMCU was first described as a new clinicopathological entity by the World Health Organization in 2017. In this review, we discuss the clinicopathological characteristics of previously reported EBVMCU cases, while focusing on up-to-date clinical, pathological, and genetic aspects.

scholarly journals OROPHARYNGEAL MICROBIOTA IN CHILDREN WITH WEB INFECTION ON THE BACKGROUND OF ANTIBIOTIC THERAPY

2021 ◽  
Vol 3 (10(74)) ◽  
pp. 15-18
Author(s):  
L. Romanyuk ◽  
N. Kravets
Keyword(s):  
Antibiotic Therapy ◽  
Epstein Barr Virus ◽  
Antibiotic Sensitivity ◽  
World Health ◽  
Treatment Protocols ◽  
Barr Virus ◽  
The World ◽  
Epstein Barr ◽  
Clinically Significant ◽  
Health Organization

According to statistics from the World Health Organization, infectious mononucleosis caused by Epstein-Barr virus affects 90% of the world's population. The aim of this study was to study the composition of the oropharyngeal microbiota and to determine the antibiotic sensitivity of its representatives, which are released in clinically significant concentrations from children with WEB infection who received antibiotic therapy. 28 patients with WEB infection in children aged 5 to 16 years were examined. Among the 28 children in inpatient treatment, 78.6% were patients under the age of 10. All children received antibiotic therapy, although according to treatment protocols, it is indicated only in the case of a bacterial infection. Streptococcus spp. with β-hemolysis (64.3%). Detection of S. aureus in 35.7% of patients indicates a violation of the structure of the normal microbiocenosis of the oropharynx. The study of antibiotic susceptibility of staphylococci and streptococci showed the presence of resistance in 52.6% of isolated strains of streptococci and 25.0% of staphylococci to azithromycin.

scholarly journals Lymphomas differ in their dependence on Epstein-Barr virus

Blood ◽  
2011 ◽  
Vol 117 (6) ◽  
pp. 1977-1985 ◽  
Author(s):  
David T. Vereide ◽  
Bill Sugden
Keyword(s):  
Tumor Cells ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Host Cells ◽  
World Health ◽  
Posttransplant Lymphoproliferative Disorder ◽  
Barr Virus ◽  
Epstein Barr ◽  
Health Organization

AbstractEpstein-Barr virus (EBV) encodes oncogenic information and, oftentimes concomitant with host immunosuppression, gives rise to malignancies in all major categories of lymphoma defined by the World Health Organization.1 Here, we conditionally evicted the viral extrachromosomal genome from tumor cells in vitro to examine the role of EBV in different lymphomas, including Burkitt lymphoma (BL) and posttransplant lymphoproliferative disorder. Cells derived from 2 canonical BLs were found to have the least dependence on the virus; some required EBV to prevent the inefficient induction of apoptosis. In contrast, cells derived from a subset of BL, Wp-restricted BL, required EBV to block a robust apoptotic program that involves the up-regulation of the proapoptotic protein Bim. Wp-restricted BL cells also relied on the virus to promote efficient proliferation, a distinction that highlights the multiple contributions EBV makes to affect proliferation of its host cells. Like Wp-BL cells, posttransplant lymphoproliferative disorder cells depended on the virus to inhibit apoptosis. They furthermore required the virus to drive them out of G1/G0. Together, these results reveal a graded dependence on EBV among tumor cells that directly correlates with the number of viral genes expressed in the tumor cell.

Clinicopathological Characteristics and Prognostic Value of Epstein-Barr Virus-associated Gastric Cancer, Microsatellite Instability and PD-L1 Immunoexpression

2017 ◽  
Vol 112 ◽  
pp. S665-S667
Author(s):  
Marina Alessandra Pereira ◽  
Marcus Fernando Kodama Pertille Ramos ◽  
André Roncon Dias ◽  
Sheila Friedrich Faraj ◽  
Osmar Kenji Yagi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Microsatellite Instability ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Clinicopathological Characteristics ◽  
Barr Virus ◽  
Epstein Barr
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