scholarly journals The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine

2019 ◽  
Vol 2 (6) ◽  
pp. 163-168
Author(s):  
Junko Shimamoto ◽  
Teruo Kurokawa ◽  
Hideaki Tanizaki ◽  
Shinichi Moriwaki
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Psoriasis Vulgaris ◽  
Urinary Level

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

scholarly journals Effects of Virtual Reality Immersion and Audiovisual Distraction Techniques for Patients with Pruritus

2009 ◽  
Vol 14 (4) ◽  
pp. 283-286 ◽  
Author(s):  
Vera Leibovici ◽  
Florella Magora ◽  
Sarale Cohen ◽  
Arieh Ingber
Keyword(s):  
Virtual Reality ◽  
Atopic Dermatitis ◽  
Psoriasis Vulgaris ◽  
Brain Activity ◽  
Computer Game ◽  
Functional Magnetic Resonance ◽  
Before And After ◽  
Chronic Pruritus ◽  
Subjective Reports ◽  
Advanced Computer

BACKGROUND: Virtual reality immersion (VRI), an advanced computer-generated technique, decreased subjective reports of pain in experimental and procedural medical therapies. Furthermore, VRI significantly reduced pain-related brain activity as measured by functional magnetic resonance imaging. Resemblance between anatomical and neuroendocrine pathways of pain and pruritus may prove VRI to be a suitable adjunct for basic and clinical studies of the complex aspects of pruritus.OBJECTIVES: To compare effects of VRI with audiovisual distraction (AVD) techniques for attenuation of pruritus in patients with atopic dermatitis and psoriasis vulgaris.METHODS: Twenty-four patients suffering from chronic pruritus – 16 due to atopic dermatitis and eight due to psoriasis vulgaris – were randomly assigned to play an interactive computer game using a special visor or a computer screen. Pruritus intensity was self-rated before, during and 10 min after exposure using a visual analogue scale ranging from 0 to 10. The interviewer rated observed scratching on a three-point scale during each distraction program.RESULTS: Student’sttests were significant for reduction of pruritus intensity before and during VRI and AVD (P=0.0002 and P=0.01, respectively) and were significant only between ratings before and after VRI (P=0.017). Scratching was mostly absent or mild during both programs.CONCLUSIONS: VRI and AVD techniques demonstrated the ability to diminish itching sensations temporarily. Further studies on the immediate and late effects of interactive computer distraction techniques to interrupt itching episodes will open potential paths for future pruritus research.

Selected serum oxidative stress biomarkers in dogs with non-food-induced and food-induced atopic dermatitis

2018 ◽  
Vol 29 (3) ◽  
pp. 229-e82 ◽  
Author(s):  
Ramón M. Almela ◽  
Camila P. Rubio ◽  
José J. Cerón ◽  
Agustina Ansón ◽  
Alexander Tichy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

scholarly journals Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies

Dermatology ◽  
2020 ◽  
pp. 1-12
Author(s):  
Cheryl Wei Ling Teo ◽  
Shawn Han Yueh Tay ◽  
Hong Liang Tey ◽  
Yee Wei Ung ◽  
Wei Ney Yap
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Vitamin E ◽  
Clinical Studies ◽  
Review Article ◽  
Adjunctive Treatment ◽  
Future Research ◽  
Future Prospects ◽  
Contact Allergen ◽  
The Relationship

<b><i>Background:</i></b> Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. <b><i>Summary:</i></b> This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.

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