scholarly journals Vitamin E in Atopic Dermatitis: From Preclinical to Clinical Studies

Dermatology ◽  
2020 ◽  
pp. 1-12
Author(s):  
Cheryl Wei Ling Teo ◽  
Shawn Han Yueh Tay ◽  
Hong Liang Tey ◽  
Yee Wei Ung ◽  
Wei Ney Yap
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Vitamin E ◽  
Clinical Studies ◽  
Review Article ◽  
Adjunctive Treatment ◽  
Future Research ◽  
Future Prospects ◽  
Contact Allergen ◽  
The Relationship

<b><i>Background:</i></b> Oxidative stress and inflammation are some of the proposed mechanisms involved in the pathogenesis of atopic dermatitis (AD). Current pharmacotherapeutic approaches are effective yet they are not without adverse effects. Vitamin E has great potential as an adjunctive treatment for AD owing to its antioxidant and anti-inflammatory bioactivities. <b><i>Summary:</i></b> This review article summarizes the current available evidence from cellular, animal and clinical studies on the relationship between vitamin E and AD. The future prospects of vitamin E are also discussed. Vitamin E in practice does not show any toxicity to humans within a range of reasonable dosage. Albeit rarely, vitamin E as a contact allergen should be considered. Collectively, this review envisaged vitamin E as an adjunctive treatment for AD patients. Future research on the distinct effects of different vitamin E isoforms as well as their delivery system in skin disorders is needed.

scholarly journals Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

2021 ◽  
Vol 22 (12) ◽  
pp. 6222
Author(s):  
Kacper Szewczyk ◽  
Aleksandra Chojnacka ◽  
Magdalena Górnicka
Keyword(s):  
Vitamin E ◽  
Metabolic Disorders ◽  
Tissue Concentration ◽  
Biological Properties ◽  
Biological Role ◽  
Future Research ◽  
The Past ◽  
The Subject ◽  
The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

The Effects of Organizational Socialization and Leadership Behavior on Burnout

2015 ◽  
pp. 224-245
Author(s):  
Jennifer H. Gao
Keyword(s):  
Emotional Exhaustion ◽  
Organizational Socialization ◽  
Leadership Behaviors ◽  
Southern China ◽  
Leadership Behavior ◽  
Personal Accomplishment ◽  
Future Research ◽  
Future Prospects ◽  
Coworker Support ◽  
The Relationship

The relationship between organizational socialization (Training, Understanding, Coworker Support, and Future Prospects) and leadership behavior (Monitor, Producer, Consideration for Others, and Trust in Others) and burnout (Emotional Exhaustion and Personal Accomplishment) were explored and discussed in this chapter. Data were collected from 341 Chinese manufacturing workers in Southern China. Results revealed that organizational socialization was highly and negatively correlated with Emotional Exhaustion, but highly and positively with Personal Accomplishment. Monitor, Consideration, and Trust were highly and negatively correlated with Emotional Exhaustion, but all the four leadership behaviors were highly and positively correlated with Personal Accomplishment. Regression revealed Training and Monitor to be significant predictors of Emotional Exhaustion, and Understanding, Coworker Support, and Trust explained significant variance of Personal Accomplishment. Management implications are discussed, and future research is indicated.

scholarly journals Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

2020 ◽  
Vol 11 ◽  
Author(s):  
Jiah Ning Tan ◽  
Shamin Mohd Saffian ◽  
Fhataheya Buang ◽  
Zakiah Jubri ◽  
Ibrahim Jantan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Clinical Studies ◽  
Glycogen Synthase ◽  
Chemical Constituents ◽  
Future Research ◽  
Prostaglandin E ◽  
Pharmacokinetic Studies ◽  
Related Factor ◽  
Anti Inflammatory

Background:Gynura species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding Gynura species that exhibited antioxidant and anti-inflammatory effects, thus providing perspectives and instructions for future research of the plants as a potential source of new dietary supplements or medicinal agents.Methods: A literature search from internet databases of PubMed, Scopus, Science Direct, e-theses Online Service, and ProQuest was carried out using a combination of keywords such as “Gynura,” “antioxidant,” “anti-inflammatory,” or other related words. Research articles were included in this study if they were experimental (in vitro and in vivo) or clinical studies on the antioxidant or anti-inflammatory effects of Gynura species and if they were articles published in English.Results: Altogether, 27 studies on antioxidant and anti-inflammatory effects of Gynura species were selected. The antioxidant effects of Gynura species were manifested by inhibition of reactive oxygen species production and lipid peroxidation, modulation of glutathione-related parameters, and enzymatic antioxidant production or activities. The anti-inflammatory effects of Gynura species were through the modulation of inflammatory cytokine production, inhibition of prostaglandin E2 and nitric oxide production, cellular inflammatory-related parameters, and inflammation in animal models. The potential anti-inflammatory signaling pathways modulated by Gynura species are glycogen synthase kinase-3, nuclear factor erythroid 2-related factor 2, PPARγ, MAPK, NF-κB, and PI3K/Akt. However, most reports on antioxidant and anti-inflammatory effects of the plants were on crude extracts, and the chemical constituents contributing to bioactivities were not clearly understood. There is a variation in quality of studies in terms of design, conduct, and interpretation, and in-depth studies on the underlying mechanisms involved in antioxidant and anti-inflammatory effects of the plants are in demand. Moreover, there is limited clinical study on antioxidant and anti-inflammatory effects of Gynura species.Conclusion: This review highlighted antioxidant and anti-inflammatory effects of genus Gynura and supported their traditional uses to treat oxidative stress and inflammatory-related diseases. This review is expected to catalyze further studies on genus Gynura. However, extensive preclinical data need to be generated from toxicity and pharmacokinetic studies before clinical studies can be pursued for their development into clinical medicines to treat oxidative stress and inflammatory conditions.

Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

2014 ◽  
Vol 175 (22) ◽  
pp. 560-560 ◽  
Author(s):  
A. Plevnik Kapun ◽  
J. Salobir ◽  
A. Levart ◽  
G. Tav ar Kalcher ◽  
A. Nemec Svete ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Vitamin E ◽  
Clinical Signs ◽  
Oxidative Stress Markers ◽  
Canine Atopic Dermatitis ◽  
Stress Markers ◽  
Vitamin E Supplementation

scholarly journals The Role of Proteasome Inhibitors in Treating Acute Lymphoblastic Leukaemia

2021 ◽  
Vol 11 ◽  
Author(s):  
Chun-fung Sin ◽  
Pui-hei Marcus Man
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Mechanism Of Action ◽  
Lymphoblastic Leukaemia ◽  
Clinical Studies ◽  
Proteasome Inhibitors ◽  
Paediatric Population ◽  
Review Article ◽  
Future Research ◽  
Attractive Alternative ◽  
Refractory Disease

Acute lymphoblastic leukaemia (ALL) is an aggressive haematolymphoid malignancy. The prognosis of ALL is excellent in paediatric population, however the outcome of relapse/refractory disease is dismal. Adult ALL has less favourable prognosis and relapse/refractory disease is not uncommonly encountered. Bortezomib is the first generation proteasome inhibitor licensed to treat plasma cell myeloma and mantle cell lymphoma with favourable side effect profile. Efficacy of bortezomib had been proven in other solid tumors. Clinical studies showed promising response for proteasome inhibitors in treating relapse/refractory ALL. Thus, proteasome inhibitors are attractive alternative agents for research in treating ALL. In the review article, we will introduce different proteasome inhibitors and their difference in pharmacological properties. Moreover, the mechanism of action of proteasome inhibitors on ALL will be highlighted. Finally, results of various clinical studies on proteasome inhibitors in both paediatric and adult ALL will be discussed. This review article provides the insights on the use of proteasome inhibitors in treating ALL with a summary of mechanism of action in ALL which facilitates future research on its use to improve the outcome of ALL.

scholarly journals The Relationship Between Maternal Vitamin E and Progress of Children Asthma: A Review Article

2020 ◽  
Vol 8 (2) ◽  
pp. 51-54
Author(s):  
Zeinab Nazari ◽  
◽  
Javad Ghaffari ◽  
Abbas Dabaghzadeh ◽  
Negar Ghaffari ◽  
...  
Keyword(s):  
Vitamin E ◽  
Review Article ◽  
Maternal Vitamin ◽  
The Relationship

N/A

scholarly journals Adverse effects of organophosphorus pesticides on the liver: a brief summary of four decades of research

2017 ◽  
Vol 68 (4) ◽  
pp. 261-275 ◽  
Author(s):  
Somayyeh Karami-Mohajeri ◽  
Ahmad Ahmadipour ◽  
Hamid-Reza Rahimi ◽  
Mohammad Abdollahi
Keyword(s):  
Oxidative Stress ◽  
Organophosphorus Pesticides ◽  
Review Article ◽  
Biological Processes ◽  
Antioxidant Defence ◽  
Antioxidant Defence System ◽  
The Relationship ◽  
Harmful Effects

Abstract Organophosphorus pesticides (OPs) are widely used volatile pesticides that have harmful effects on the liver in acute and chronic exposures. This review article summarises and discusses a wide collection of studies published over the last 40 years reporting on the effects of OPs on the liver, in an attempt to propose general mechanisms of OP hepatotoxicity and possible treatment. Several key biological processes have been reported as involved in OP-induced hepatotoxicity such as disturbances in the antioxidant defence system, oxidative stress, apoptosis, and mitochondrial and microsomal metabolism. Most studies show that antioxidants can attenuate oxidative stress and the consequent changes in liver function. However, few studies have examined the relationship between OP structures and the severity and mechanism of their action. We hope that future in vitro, in vivo, and clinical trials will answer the remaining questions about the mechanisms of OP hepatotoxicity and its management.

scholarly journals Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 697
Author(s):  
Oriana Simonetti ◽  
Tiziana Bacchetti ◽  
Gianna Ferretti ◽  
Elisa Molinelli ◽  
Giulio Rizzetto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Lipid Hydroperoxides ◽  
Polymorphonuclear Cells ◽  
Inflammatory Skin Diseases ◽  
Total Antioxidant ◽  
Inflammatory Skin ◽  
Total Antioxidant Potential ◽  
The Relationship

Background: previous studies reported the involvement of reactive oxygen species (ROS) and lipid peroxidation in the pathogenesis of inflammatory skin diseases. The aim of our study was to investigate the relationship between oxidative stress and inflammation in children affected by atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. Methods: levels of lipid hydroperoxides, total antioxidant capacity, and activities of the enzymes myeloperoxidase (MPO), PON1, and PON2/3 were investigated in 56 atopic pediatric patients, and compared with 48 sex-/age-matched healthy controls. Results: significantly higher levels of lipid hydroperoxides and lower values of total antioxidant potential were observed in the serum of AD children compared to that of the controls. Significant lower PON1 activities, and a significant increase in levels of MPO were observed in serum of patients, with a higher serum MPO level/PON1 paraoxonase activity ratio in patients compared to that in the controls. Significantly lower lactonase activity of PON enzymes was observed in polymorphonuclear cells isolated from AD patients. Statistically negative correlation was established between the activity of intracellular PON2/3 activity and ROS levels. Conclusions: our data confirmed that AD is associated with higher oxidative damage and a decrease in antioxidant defense. Moreover, alterations of extracellular and intracellular PON activity can promote lipoprotein dysfunction in AD patients.

scholarly journals The relationship between dose of vitamin E and suppression of oxidative stress in humans

2007 ◽  
Vol 43 (10) ◽  
pp. 1388-1393 ◽  
Author(s):  
L ROBERTSII ◽  
J OATES ◽  
M LINTON ◽  
S FAZIO ◽  
B MEADOR ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document