ChemInform Abstract: Metal-Organic Hybrid Architectures Built from Functionalized Fullerenes and Metal Ions or Clusters

ChemInform ◽  
2016 ◽  
Vol 47 (45) ◽  
Author(s):  
Andreas Kraft ◽  
Florian Beuerle
Keyword(s):  
Metal Ions ◽  
Hybrid Architectures ◽  
Organic Hybrid ◽  
Functionalized Fullerenes ◽  
Metal Organic

Metal-organic Nanopharmaceuticals

2020 ◽  
Vol 8 (3) ◽  
pp. 163-190
Author(s):  
Benjamin Steinborn ◽  
Ulrich Lächelt
Keyword(s):  
Metal Ions ◽  
Coordination Polymers ◽  
Active Agent ◽  
Lewis Base ◽  
High Loading ◽  
Active Components ◽  
Base Functions ◽  
Metal Organic ◽  
Theranostic Applications ◽  
Pharmacologically Active

: Coordinative interactions between multivalent metal ions and drug derivatives with Lewis base functions give rise to nanoscale coordination polymers (NCPs) as delivery systems. As the pharmacologically active agent constitutes a main building block of the nanomaterial, the resulting drug loadings are typically very high. By additionally selecting metal ions with favorable pharmacological or physicochemical properties, the obtained NCPs are predominantly composed of active components which serve individual purposes, such as pharmacotherapy, photosensitization, multimodal imaging, chemodynamic therapy or radiosensitization. By this approach, the assembly of drug molecules into NCPs modulates pharmacokinetics, combines pharmacological drug action with specific characteristics of metal components and provides a strategy to generate tailorable multifunctional nanoparticles. This article reviews different applications and recent examples of such highly functional nanopharmaceuticals with a high ‘material economy’. : Lay Summary: Nanoparticles, that are small enough to circulate in the bloodstream and can carry cargo molecules, such as drugs, imaging or contrast agents, are attractive materials for pharmaceutical applications. A high loading capacity is a generally aspired parameter of nanopharmaceuticals to minimize patient exposure to unnecessary nanomaterial. Pharmaceutical agents containing Lewis base functions in their molecular structure can directly be assembled into metal-organic nanopharmaceuticals by coordinative interaction with metal ions. Such coordination polymers generally feature extraordinarily high loading capacities and the flexibility to encapsulate different agents for a simultaneous delivery in combination therapy or ‘theranostic’ applications.

Core-shell ZIF-8@polydopamine nanoparticles obtained by mitigating polydopamine coating induced self-etching of MOFs: prototypical metal ion reservoirs for sticking to and killing bacteria

2021 ◽  
Author(s):  
Yingxue Tu ◽  
Caifen Lei ◽  
Fei Deng ◽  
Yiang Chen ◽  
Ying Wang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Core Shell ◽  
Metal Organic

Metal organic frameworks (MOFs) have the potential to boost the undervalued biomedical applications of metal ions. Such endeavor has been hindered by the challenge of how to avoid the (cyto)toxicity...

In situ fabrication of metal–organic hybrid gels in a capillary for online enrichment of trace analytes in aqueous samples

2012 ◽  
Vol 48 (33) ◽  
pp. 3966 ◽  
Author(s):  
Yuling Hu ◽  
Yifeng Fan ◽  
Zelin Huang ◽  
Chaoyong Song ◽  
Gongke Li
Keyword(s):  
Aqueous Samples ◽  
Hybrid Gels ◽  
Organic Hybrid ◽  
In Situ Fabrication ◽  
Metal Organic

Enhanced performance in gas adsorption and Li ion batteries by docking Li+ in a crown ether-based metal–organic framework

2016 ◽  
Vol 52 (14) ◽  
pp. 3003-3006 ◽  
Author(s):  
Linyi Bai ◽  
Binbin Tu ◽  
Yi Qi ◽  
Qiang Gao ◽  
Dong Liu ◽  
...  
Keyword(s):  
Crown Ether ◽  
Metal Ions ◽  
Gas Adsorption ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Li Ion Batteries ◽  
Metal Organic ◽  
Li Ion ◽  
Organic Framework

Incorporating supramolecular recognition units, crown ether rings, into metal–organic frameworks enables the docking of metal ions through complexation for enhanced performance.

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