ChemInform Abstract: Ce(SO4)2-Catalyzed the Highly Diastereoselective Synthesis of Tetrahydroquinolines via an Imino Diels-Alder ABB′ Type Reaction and Their in vivo Toxicity and Imaging in Zebrafish Embryos.

ChemInform ◽  
2016 ◽  
Vol 47 (35) ◽  
Author(s):  
Carlos A. Martinez Bonilla ◽  
Carlos E. Puerto Galvis ◽  
Leonor Y. Vargas Mendez ◽  
Vladimir V. Kouznetsov
Keyword(s):  
Diels Alder ◽  
Zebrafish Embryos ◽  
Diastereoselective Synthesis ◽  
In Vivo Toxicity ◽  
Type Reaction

Ce(SO4)2-catalysed the highly diastereoselective synthesis of tetrahydroquinolines via an imino Diels Alder ABB′ type reaction and their in vivo toxicity and imaging in zebrafish embryos

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37478-37486 ◽  
Author(s):  
Carlos A. Martínez Bonilla ◽  
Carlos E. Puerto Galvis ◽  
Leonor Y. Vargas Méndez ◽  
Vladimir V. Kouznetsov
Keyword(s):  
Zebrafish Embryo ◽  
Diels Alder ◽  
Zebrafish Embryos ◽  
Diastereoselective Synthesis ◽  
In Vivo Toxicity ◽  
Type Reaction ◽  
Povarov Reaction

The synthesis of tetrahydroquinolines via the Povarov reaction has been developed using Ce(SO2)4 as a catalyst. This efficient protocol allowed the toxicity and phenotypic study of these products using a zebrafish embryo model.

Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos

2016 ◽  
Vol 45 (47) ◽  
pp. 19127-19140 ◽  
Author(s):  
O. A. Lenis-Rojas ◽  
A. R. Fernandes ◽  
C. Roma-Rodrigues ◽  
P. V. Baptista ◽  
F. Marques ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Dna Interaction ◽  
Zebrafish Embryos ◽  
In Vivo Toxicity ◽  
Mononuclear Compounds

Cytotoxic properties, DNA-interaction and in vivo toxicity were evaluated in Ru(ii) compounds.

scholarly journals Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos

2019 ◽  
Vol 38 (3) ◽  
pp. 702-711 ◽  
Author(s):  
Golara Golbaghi ◽  
Mohammad Mehdi Haghdoost ◽  
Debbie Yancu ◽  
Yossef López de los Santos ◽  
Nicolas Doucet ◽  
...  
Keyword(s):  
Biological Activity ◽  
Aromatase Inhibitor ◽  
Zebrafish Embryos ◽  
In Vivo Toxicity

Sodium Cholate-Templated Blue Light-Emitting Ag Subnanoclusters: In Vivo Toxicity and Imaging in Zebrafish Embryos

2015 ◽  
Vol 7 (3) ◽  
pp. 1422-1430 ◽  
Author(s):  
Shanmugam Chandirasekar ◽  
Chandramouli Chandrasekaran ◽  
Thangavel Muthukumarasamyvel ◽  
Ganapasam Sudhandiran ◽  
Nagappan Rajendiran
Keyword(s):  
Blue Light ◽  
Sodium Cholate ◽  
Zebrafish Embryos ◽  
Light Emitting ◽  
In Vivo Toxicity

scholarly journals The Antibacterial Efficacy and In Vivo Toxicity of Sodium Hypochlorite and Electrolyzed Oxidizing (EO) Water-Based Endodontic Irrigating Solutions

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 260
Author(s):  
Sung-Chih Hsieh ◽  
Nai-Chia Teng ◽  
Chia Chun Chu ◽  
You-Tai Chu ◽  
Chung-He Chen ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Enterococcus Faecalis ◽  
Sodium Hypochlorite ◽  
Hypochlorous Acid ◽  
Plate Count ◽  
Zebrafish Embryos ◽  
Microbial Count ◽  
Antibacterial Efficacy ◽  
In Vivo Toxicity

The objective of this study was to evaluate the antibacterial efficacy against Enterococcus faecalis and Streptococcus mutans and in vivo toxicity using embryonic zebrafish assays of sodium hypochlorite (NaOCl) and electrolyzed oxidizing (EO) water (containing hypochlorous acid (HOCl))-based root canal irrigating solutions. Methodology: Using 100 μL microbial count of 1 × 108 cfu/mL Enterococcus faecalis to mix with each 10 mL specimen of NaOCl or HOCl for designed time periods. The above protocol was also repeated for Streptococcus mutans. The concentration of viable microorganisms was estimated based on each standardized inoculum using a plate-count method. Zebrafish embryo assays were used to evaluate acute toxicity. Results: All the HOCl or NaOCl treatment groups showed > 99.9% antibacterial efficacy against Enterococcus faecalis and Streptococcus mutans. Zebrafish embryos showed almost complete dissolution in 1.5% NaOCl within 5 min. Both survival rates after being treated with 0.0125% and 0.0250% HOCl for 0.5 min or 1.0 min were similar to that of E3 medium. Conclusions: Both NaOCl and HOCl revealed similar antibacterial efficacy (> 99.9%) against Enterococcus faecalis and Streptococcus mutans. While 1.5% NaOCl fully dissolved the Zebrafish embryos, both 0.0125% and 0.0250% HOCl showed little in vivo toxicity, affirming its potential as an alternative irrigation solution for vital pulp therapy.

Silver nanoparticles: in vivo toxicity in zebrafish embryos and a comparison to silver nitrate

2016 ◽  
Vol 18 (8) ◽  
Author(s):  
Dina A. Mosselhy ◽  
Wei He ◽  
Dan Li ◽  
Yaping Meng ◽  
Qingling Feng
Keyword(s):  
Silver Nanoparticles ◽  
Silver Nitrate ◽  
Zebrafish Embryos ◽  
In Vivo Toxicity
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