ChemInform Abstract: Asymmetric Addition of α-Branched Cyclic Ketones to Allenamides Catalyzed by a Chiral Phosphoric Acid.

ChemInform ◽  
2016 ◽  
Vol 47 (32) ◽  
Author(s):  
Xiaoyu Yang ◽  
F. Dean Toste
Keyword(s):  
Phosphoric Acid ◽  
Cyclic Ketones ◽  
Asymmetric Addition ◽  
Chiral Phosphoric Acid

scholarly journals Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid

2016 ◽  
Vol 7 (4) ◽  
pp. 2653-2656 ◽  
Author(s):  
Xiaoyu Yang ◽  
F. Dean Toste
Keyword(s):  
Phosphoric Acid ◽  
Acid Catalyst ◽  
Cyclic Ketones ◽  
Asymmetric Addition ◽  
Chiral Phosphoric Acid ◽  
Quaternary Stereocenter

Asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid catalyst, generates an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity.

Direct enantioselective Mannich reactions of α-azido cyclic ketones: asymmetric construction of chiral azides possessing an α-quaternary stereocenter

2020 ◽  
Vol 56 (1) ◽  
pp. 98-101 ◽  
Author(s):  
Xueqian Ye ◽  
Yongkai Pan ◽  
Xiaoyu Yang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Synthesis ◽  
Cyclic Ketones ◽  
Mannich Reactions ◽  
Chiral Phosphoric Acid ◽  
Quaternary Stereocenter

Herein, we report the asymmetric synthesis of chiral azides possessing an α-quaternary stereocenter via chiral phosphoric acid catalysed direct enantioselective Mannich reactions of α-azido cyclic ketones with aldimines.

Chiral phosphoric acid catalyzed asymmetric addition of naphthols to para-quinone methides

2016 ◽  
Vol 14 (24) ◽  
pp. 5751-5754 ◽  
Author(s):  
Yuk Fai Wong ◽  
Zhaobin Wang ◽  
Jianwei Sun
Keyword(s):  
Phosphoric Acid ◽  
Quinone Methides ◽  
Asymmetric Addition ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

An asymmetric addition of naphthols to in situ generated para-quinone methides catalyzed by a chiral phosphoric acid is described.

Asymmetric Addition of Pyrazolones to Allenamides Catalyzed by a Chiral Phosphoric Acid

2018 ◽  
Vol 2018 (46) ◽  
pp. 6469-6473 ◽  
Author(s):  
Kai Yang ◽  
Xiaoze Bao ◽  
Siyuan Liu ◽  
Jingnan Xu ◽  
Jingping Qu ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Addition ◽  
Chiral Phosphoric Acid

scholarly journals A Molecular Stereostructure Descriptor Based On Spherical Projection

Synlett ◽  
2020 ◽  
Author(s):  
Shuo-Qing Zhang ◽  
Xin Hong ◽  
Li-Cheng Xu ◽  
Xin Li ◽  
Miao-Jiong Tang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Van Der Waals ◽  
Chiral Phosphoric Acid ◽  
Key Features ◽  
Precise Representation ◽  
Spherical Projection

AbstractDescription of molecular stereostructure is critical for the machine learning prediction of asymmetric catalysis. Herein we report a spherical projection descriptor of molecular stereostructure (SPMS), which allows precise representation of the molecular van der Waals (vdW) surface. The key features of SPMS descriptor are presented using the examples of chiral phosphoric acid, and the machine learning application is demonstrated in Denmark’s dataset of asymmetric thiol addition to N-acylimines. In addition, SPMS descriptor also offers a color-coded diagram that provides straightforward chemical interpretation of the steric environment.

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