A highly efficient approach to the construction of indolizidines and quinolizidines bearing a bridged quaternary stereocenter has been established in a one-pot fashion using aldehydes, nitroalkenes, and cyclic ketimines.
SnCl4 or TiCl4 catalysts provide a rapid and efficient detetrahydropyranylation and demethoxymethylation of phenolic ethers and a sequential one-pot intramolecular Friedel–Crafts alkylation of chalcone epoxides under mild reaction conditions.
A highly efficient organocatalytic one-pot approach for enantioselective synthesis of (R)-2-aryl-2,3-dihydro-4-quinolones from o-aminoacetophenones and aryl aldehydes has been achieved.
Lactols or cyclic hemiaminals are directly used as nucleophiles in the asymmetric aza-Diels–Alder reaction to synthesize ring-fused piperidine derivatives.
Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl
acids have been accomplished through stereoselective glycosylation of various peracetylated
bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed
by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic
activity of InBr3 has been successfully investigated in a one-pot procedure. The
resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids)
could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a
wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive
molecules of diverse medicinal interest.