ChemInform Abstract: Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite.

ChemInform ◽  
2016 ◽  
Vol 47 (11) ◽  
pp. no-no
Author(s):  
Andre Shavnya ◽  
Kevin D. Hesp ◽  
Vincent Mascitti ◽  
Aaron C. Smith
Keyword(s):  
Boronic Acids ◽  
Alkyl Halides ◽  
Palladium Catalyzed

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite

2015 ◽  
Vol 127 (46) ◽  
pp. 13775-13779 ◽  
Author(s):  
Andre Shavnya ◽  
Kevin D. Hesp ◽  
Vincent Mascitti ◽  
Aaron C. Smith
Keyword(s):  
Boronic Acids ◽  
Alkyl Halides ◽  
Palladium Catalyzed

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

Synthesis ◽  
2021 ◽  
Author(s):  
Antonella Goggiamani ◽  
Antonia Iazzetti ◽  
Antonio Arcadi ◽  
Andrea Calcaterra ◽  
Marco Chiarini ◽  
...  
Keyword(s):  
Boronic Acids ◽  
Experimental Procedure ◽  
Palladium Catalyzed ◽  
High Yields ◽  
Reaction Works

AbstractThe palladium-catalyzed synthesis of indole/benzofuran-containing diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.

Visible-light-mediated borylation of aryl and alkyl halides with a palladium complex

2020 ◽  
Vol 18 (23) ◽  
pp. 4390-4394
Author(s):  
Jia-Hui Zhao ◽  
Zhao-Zhao Zhou ◽  
Yue Zhang ◽  
Xuan Su ◽  
Xi-Meng Chen ◽  
...  
Keyword(s):  
Visible Light ◽  
Functional Group ◽  
Palladium Complex ◽  
Alkyl Halides ◽  
Palladium Catalyzed ◽  
High Yields

Palladium catalyzed visible-light-mediated borylation of inactivated aryl and alkyl halides is reported; the method provided high yields and excellent functional group compatibility.

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